C. Tsu

发表

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.

J. Whisstock, J. Irving, L. Juliano, 2000, Biochemistry.

Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.

R. Fletterick, C. Craik, J. Perona, 1997, Biochemistry.

The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis

L. Tilley, M. Parker, C. Morton, 2019, Nature Microbiology.

SRP-2 Is a Cross-class Inhibitor That Participates in Postembryonic Development of the Nematode Caenorhabditis elegans

D. R. Mills, D. Brömme, G. Silverman, 2004, Journal of Biological Chemistry.

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells

S. Pomeroy, D. Perlmutter, G. Silverman, 2000, International journal of cancer.

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.

M. Rolfe, A. Berger, Jie Yu, 2010, Cancer research.

Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates*

L. Dick, C. Nathan, C. Tsu, 2008, Journal of Biological Chemistry.

Characterization of a New Series of Non-covalent Proteasome Inhibitors with Exquisite Potency and Selectivity for the 20s Β5-subunit Figure S1 Activities of Compound 1 and Bortezomib in Cells

T. Soucy, E. Olhava, M. Sintchak, 2010 .

Why the Structure but Not the Activity of the Immunoproteasome Subunit Low Molecular Mass Polypeptide 2 Rescues Antigen Presentation

M. Przybylski, A. Kisselev, M. Groettrup, 2012, The Journal of Immunology.

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00220j

L. Dick, F. Wolenski, V. Csizmadia, 2016, Toxicology research.

Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity*

Christopher Tsu, A. Goldberg, T. Akopian, 2015, The Journal of Biological Chemistry.

Proteasome inhibitors bortezomib and car fi lzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA 2 / Omi †

L. Dick, F. Wolenski, V. Csizmadia, 2016 .

Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib

M. Rolfe, G. Weatherhead, Julie Zhang, 2006, Molecular Cancer Therapeutics.

Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates*

L. Dick, C. Nathan, C. Tsu, 2008, Journal of Biological Chemistry.

Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

M. Milhollen, James M. Gavin, J. Brownell, 2011, The Journal of Biological Chemistry.

The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases.

G. Silverman, C. Luke, S. Pak, 2006, Biochemistry.

Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity

J. M. Bradshaw, M. Lindstrom, M. Groettrup, 2018, EMBO reports.

Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome

M. Sintchak, L. Dick, J. Blank, 2012 .

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Jonathan L Blank, Christopher Tsu, Christopher Blackburn, 2010, Bioorganic & medicinal chemistry letters.

Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.

R. Fletterick, C. Craik, J. Perona, 1993, Journal of molecular biology.

Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.

R J Fletterick, R. Fletterick, C. Craik, 1997, Biochemistry.

Development of a charcoal paper adenosine triphosphate:pyrophosphate exchange assay: kinetic characterization of NEDD8 activating enzyme.

L. Dick, O. Tayber, C. Tsu, 2009, Analytical biochemistry.

Substrate Recognition by Recombinant Serine Collagenase 1 from Uca pugilator(*)

C. Craik, C. Tsu, 1996, The Journal of Biological Chemistry.

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

J. Whisstock, J. Irving, David Miller, 2002, Biochemistry.

The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA.

O. Uhlenbeck, K. Kossen, C. Tsu, 2001, RNA.

The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites.

C. Turck, C. Craik, J. Perona, 1994, The Journal of biological chemistry.

Mass Polypeptide 2 Rescues Antigen Immunoproteasome Subunit Low Molecular Why the Structure but Not the Activity of the

Reinhold Weber, Michael Basler, Michael Przybylski, 2012 .

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

T. Soucy, E. Olhava, M. Sintchak, 2010, The Biochemical journal.

Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity

T. Parsons, Huilin Li, P. Zwickl, 2006, Molecular microbiology.

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

E. Winzeler, L. Tilley, L. Dick, 2018, Journal of medicinal chemistry.

Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data.

K. Robison, G. Silverman, S. Badola, 2006, Genomics.

Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea

A. Berger, Jie Yu, L. Dick, 2011, Cancer Chemotherapy and Pharmacology.

Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome

M. Bogyo, L. Dick, C. Blackburn, 2014, Journal of the American Chemical Society.

Kinetic analysis of the RNA-dependent adenosinetriphosphatase activity of DbpA, an Escherichia coli DEAD protein specific for 23S ribosomal RNA.

O. Uhlenbeck, C. Tsu, 1998, Biochemistry.

N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.

M. Sintchak, L. Dick, C. Nathan, 2013, Journal of the American Chemical Society.

Relocating a negative charge in the binding pocket of trypsin.

R J Fletterick, R. Fletterick, C. Craik, 1994, Journal of molecular biology.