Chung-Pu Wu

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Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2020, Journal of natural products.

MY-5445, a phosphodiesterase type 5 inhibitor, resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic anticancer drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2020, American journal of cancer research.

Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter.

T. Hung, S. Ambudkar, Yu-Jen Lu, 2017, Molecular pharmaceutics.

Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2.

C. Hsieh, chiun-wei Huang, Chung-Pu Wu, 2014, Biochemical pharmacology.

cGMP (guanosine 3',5'-cyclic monophosphate) transport across human erythrocyte membranes.

S. Hladky, M. Barrand, Chung-Pu Wu, 2005, Biochemical pharmacology.

Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay

A. Yueh, Y. Chao, Szu-Huei Wu, 2010, Antimicrobial Agents and Chemotherapy.

Differentiation of oral precancerous stages with optical coherence tomography based on the evaluation of optical scattering properties of oral mucosae

Meng-Tsan Tsai, Feng-Yu Chang, Chih-Chung Yang, 2013, Laser Physics.

Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.

T. Hung, Chung-Pu Wu, Yan-qing Li, 2021, Journal of natural products.

Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2017, Molecular pharmaceutics.

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

A. Calcagno, S. Ambudkar, S. Shukla, 2007, Current drug delivery.

Mammalian target of rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies complicated by growth restriction.

T. Hung, Szu-Fu Chen, Yi-Lin Yeh, 2017, Placenta.

Noninvasive imaging of heart chamber in Drosophila with dual‐beam optical coherence tomography

Meng-Tsan Tsai, F. Chang, June-Tai Wu, 2013, Journal of biophotonics.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013, Molecular Pharmacology.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4 / Multidrug Resistance Protein 4 : A Basis for Unanticipated Enhanced Cytotoxicity s

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1.

C. Hsieh, Chung-Pu Wu, Chi-Chung Wang, 2012, Neuro-oncology.

P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhiitor Ensartinib in Cancer Cells

T. Hung, S. Ambudkar, Jau-Song Yu, 2022, Cancers.

Overexpression of ABCB1 and ABCG2 contributes to reduced efficacy of the PI3K/mTOR inhibitor samotolisib (LY3023414) in cancer cell lines.

T. Hung, S. Ambudkar, Jau-Song Yu, 2020, Biochemical pharmacology.

The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2018, Cancer letters.

The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.

S. Ambudkar, S. Hsu, Chung-Pu Wu, 2019, Cancer letters.

Human ATP-Binding Cassette Transporter ABCB1 Confers Resistance to Volasertib (BI 6727), a Selective Inhibitor of Polo-like Kinase 1.

C. Hsieh, S. Hsu, chiun-wei Huang, 2015, Molecular pharmaceutics.

Overexpression of human ABCB1 in cancer cells leads to reduced activity of GSK461364, a specific inhibitor of polo-like kinase 1.

C. Hsieh, Chung-Pu Wu, Sung-Han Hsiao, 2014, Molecular pharmaceutics.

OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance.

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Biochemical pharmacology.

Cancer esearch apeutics , Targets , and Chemical Biology tinib ( YN 968 D 1 ) Reverses Multidrug Resistance by biting the Efflux Function of Multiple ATP-Binding R sette Transporters

S. Ambudkar, Zhe-Sheng Chen, A. Tiwari, 2010 .

Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.

Fang Wang, S. Ambudkar, Zhe-Sheng Chen, 2010, Cancer research.

tinib (YN968D1) Reverses Multidrug Resistance by biting the Efflux Function of Multiple ATP-Binding

Fan Wang, S. Ambudkar, Zhe-Sheng Chen, 2010 .

Cassette Transporters Inhibiting the Efflux Function of Multiple ATP-Binding Apatinib ( YN 968 D 1 ) Reverses Multidrug Resistance

S. Ambudkar, A. Tiwari, Yong‐ju Liang, 2010 .

Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.

A. Calcagno, S. Ambudkar, Chung-Pu Wu, 2008, Current molecular pharmacology.

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat

T. Hung, S. Ambudkar, Jau-Song Yu, 2021, International journal of molecular sciences.

Increased Soluble Epoxide Hydrolase in Human Gestational Tissues from Pregnancies Complicated by Acute Chorioamnionitis

T. Hung, Szu-Fu Chen, Chun-Hu Wu, 2019, Mediators of inflammation.

Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2 (Cancer Research (2008) 68, (7905-7914))

Liwu Fu, R. Robey, S. Ambudkar, 2008 .

SIS3, a specific inhibitor of Smad3 reverses ABCB1- and ABCG2-mediated multidrug resistance in cancer cell lines.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2018, Cancer letters.

Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1)

S. Ambudkar, T. Lee, P. Limtrakul, 2006, Cancer Chemotherapy and Pharmacology.

Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.

Liwu Fu, S. Ambudkar, Zhe-Sheng Chen, 2010, Biochemical pharmacology.

The WD repeat-containing protein 5 (WDR5) antagonist WDR5-0103 restores the efficacy of cytotoxic drugs in multidrug-resistant cancer cells overexpressing ABCB1 or ABCG2.

T. Hung, Chung-Pu Wu, Yan-qing Li, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1.

S. Ambudkar, Chung-Pu Wu, Sung-Han Hsiao, 2013, Biochemical pharmacology.

Hydroxygenkwanin Improves the Efficacy of Cytotoxic Drugs in ABCG2-Overexpressing Multidrug-Resistant Cancer Cells

T. Hung, S. Ambudkar, Chung-Pu Wu, 2022, International journal of molecular sciences.

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics.

C. D. Salcido, M. Gottesman, J. Fostel, 2010, Journal of the National Cancer Institute.

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

S. Ambudkar, S. Shukla, Chung-Pu Wu, 2008, Expert opinion on drug metabolism & toxicology.

Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.

R. Robey, S. Ambudkar, Zhe-Sheng Chen, 2008, Cancer research.

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2

Suneet Shukla, S. Ambudkar, S. Shukla, 2007, Molecular Cancer Therapeutics.

In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs.

S. Ambudkar, Chung-Pu Wu, Hong-May Sim, 2011, Biochemical pharmacology.

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy

S. Thorgeirsson, M. Gottesman, S. Varma, 2016, Molecular Pharmacology.

Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants

T. Hung, Szu-Fu Chen, Chung-Pu Wu, 2021, Frontiers in Medicine.

Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

S. Hladky, M. Barrand, S. Ambudkar, 2005, Biochemical pharmacology.

cGMP and glutathione-conjugate transport in human erythrocytes.

S. Hladky, M. Barrand, H. V. van Veen, 2003, European journal of biochemistry.

Human ATP-Binding Cassette Transporter ABCG2 Confers Resistance to CUDC-907, a Dual Inhibitor of Histone Deacetylase and Phosphatidylinositol 3-Kinase.

C. Hsieh, Jau-Song Yu, chiun-wei Huang, 2016, Molecular pharmaceutics.

Modulatory effects of plant phenols on human multidrug‐resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)

S. Hladky, M. Barrand, A. Calcagno, 2005, The FEBS journal.

The Use of PET Imaging for Prognostic Integrin α2β1 Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses

T. Yen, chiun-wei Huang, W. Hsieh, 2017, Theranostics.

The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy

Chung-Pu Wu, Suresh V. Ambudkar, 2014, Acta pharmaceutica Sinica. B.

Livin Contributes to Tumor Hypoxia–Induced Resistance to Cytotoxic Therapies in Glioblastoma Multiforme

C. Hsieh, W. Shyu, Chung-Pu Wu, 2014, Clinical Cancer Research.

Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function.

S. Akiyama, S. Ambudkar, Zhe-Sheng Chen, 2009, Biochemical pharmacology.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Suneet Shukla, Michael M Gottesman, M. Gottesman, 2011, Molecular pharmaceutics.

The Second-Generation PIM Kinase Inhibitor TP-3654 Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

T. Hung, Chung-Pu Wu, Yan-qing Li, 2021, International journal of molecular sciences.

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Suneet Shukla, Michael M Gottesman, Matthew D Hall, 2007, Molecular Cancer Therapeutics.

The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy.

C. Hsieh, Chung-Pu Wu, Yu-Shan Wu, 2011, Molecular pharmaceutics.

Tyrphostin RG14620 selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines.

C. Hsieh, S. Ambudkar, Chung-Pu Wu, 2017, Cancer letters.

Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy.

S. Ambudkar, S. Ohnuma, Suresh V Ambudkar, 2011, Current pharmaceutical biotechnology.

The multi-targeted tyrosine kinase inhibitor SKLB610 resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

The third-generation EGFR inhibitor almonertinib (HS-10296) resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2021, Biochemical pharmacology.

Sitravatinib Sensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

T. Hung, Chung-Pu Wu, Sung-Han Hsiao, 2020, Cancers.

Small Molecule Chemosensitizing Agents: Polo-Like Kinase 1 (Plk1), BRAF and Janus Kinase (JAK) Inhibitors

S. Hsu, Chung-Pu Wu, 2019, Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy.

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Gabriel S. Eichler, J. Weinstein, Y. Pommier, 2009, Molecular Cancer Therapeutics.

Avapritinib: A Selective Inhibitor of KIT and PDGFRα that Reverses ABCB1 and ABCG2-Mediated Multidrug Resistance in Cancer Cell Lines.

T. Hung, S. Ambudkar, Jyun-Cheng Wang, 2019, Molecular pharmaceutics.

The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

T. Hung, S. Ambudkar, Jyun-Cheng Wang, 2019, International journal of molecular sciences.

Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins

A. Calcagno, S. Ambudkar, Suresh V Ambudkar, 2006, BMC Molecular Biology.

Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents

T. Hung, S. Ambudkar, Chung-Pu Wu, 2021, Frontiers in Cell and Developmental Biology.

Erdafitinib Resensitizes ABCB1-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

T. Hung, Chung-Pu Wu, Sung-Han Hsiao, 2020, Cancers.

Osimertinib (AZD9291) Attenuates the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCB1 in Vitro.

C. Hsieh, Chung-Pu Wu, Sung-Han Hsiao, 2016, Molecular pharmaceutics.

Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells.

S. Ambudkar, S. Hsu, Chung-Pu Wu, 2013, Biochemical pharmacology.

Human ATP‐binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY‐1215) in cancer cell lines

S. Ambudkar, Jau-Song Yu, Chung-Pu Wu, 2018, Biochemical pharmacology.

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.

T. Hung, C. Hsieh, Yu-Jen Lu, 2016, Journal of natural products.

Plasmodium falciparum expresses a multidrug resistance-associated protein.

T. Tiffert, D. V. van Schalkwyk, S. Hladky, 2004, Biochemical and biophysical research communications.

HIV protease inhibitors interact with ABCC4/MRP4: a basis for unanticipated enhanced cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance

S. Stojilkovic, S. Ambudkar, K. Kretschmannova, 2010, Molecular Pharmacology.

Reliability implications of lateral alkali-ion migration in MOS integrated circuits

R. Comizzoli, G. Schnable, K. Schlesier, 1994 .

Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression

C. Hsieh, W. Shyu, Chi-Wei Chang, 2017, Theranostics.

NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.

C. Hsieh, Ji-An Liang, Chung-Pu Wu, 2012, Free radical biology & medicine.

Decreased placental apoptosis and autophagy in pregnancies complicated by gestational diabetes with large-for-gestational age fetuses.

T. Hung, Szu-Fu Chen, Chung-Pu Wu, 2020, Placenta.

ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

T. Hung, S. Ambudkar, Jau-Song Yu, 2023, Cells.

Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme

C. Hsieh, Wei-Ling Chen, Chung-Pu Wu, 2015, Journal of Translational Medicine.

Impact of anomalous short-channel MOS transistors on VLSI circuit reliability

George L. Schnable, Kenneth M. Schlesier, George A. Swartz, 1993 .

Micronized progesterone pretreatment affects the inflammatory response of human gestational tissues and the cervix to lipopolysaccharide stimulation.

T. Hung, Szu-Fu Chen, Yi-Lin Yeh, 2017, Placenta.

Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

A. Yueh, Y. Chao, T. Yeh, 2011, Antimicrobial Agents and Chemotherapy.

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy s

S. Thorgeirsson, M. Gottesman, S. Varma, 2016 .

Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives.

K. Chibale, Peter J. Smith, Dale Taylor, 2005, International journal of antimicrobial agents.

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes

C. D. Salcido, N. Caplen, S. Bates, 2008, British Journal of Cancer.

Furmonertinib, a Third-Generation EGFR Tyrosine Kinase Inhibitor, Overcomes Multidrug Resistance through Inhibiting ABCB1 and ABCG2 in Cancer Cells

T. Hung, S. Ambudkar, Chung-Pu Wu, 2023, International journal of molecular sciences.

Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins

A. Calcagno, S. Ambudkar, Chung-Pu Wu, 2006, BMC Molecular Biology.

Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport

T. Hung, S. Ambudkar, Chung-Pu Wu, 2023, Pharmaceuticals.

Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2.

Chung-Pu Wu, Sung-Han Hsiao, Yu-Shan Wu, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The Use of PET Imaging for Prognostic Integrin α2β1 Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses

T. Yen, chiun-wei Huang, W. Hsieh, 2017, Theranostics.

Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source.

Z. Sauna, S. Ambudkar, Z. Kon, 2007, Biochemistry.