H. Kawata

发表

Establishment and characterization of an androgen receptor‐dependent, androgen‐independent human prostate cancer cell line, LNCaP‐CS10

Ayako Nishimoto, Nobuyuki Ishikura, H. Kawata, 2010, The Prostate.

A novel nonsecosteroidal VDR agonist (CH5036249) exhibits efficacy in a spontaneous benign prostatic hyperplasia beagle model

Y. Sugimoto, A. Harada, H. Kawata, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Internalization with high targeting potential of mouse monoclonal antibody ONS-M21 recognizing human malignant glioma antigen.

H. Kishima, Y. Sekimori, T. Hayakawa, 1998, Cancer letters.

Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer.

T. Shiraishi, Ayako Nishimoto, Nobuyuki Ishikura, 2010, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists.

Nobuyuki Ishikura, H. Kawata, E. Onuma, 2007, Bioorganic & medicinal chemistry letters.

Discovery of an orally-active nonsteroidal androgen receptor pure antagonist and the structure-activity relationships of its derivatives.

T. Shiraishi, Nobuyuki Ishikura, H. Kawata, 2008, Chemical & pharmaceutical bulletin.

Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists.

T. Shiraishi, Nobuyuki Ishikura, H. Kawata, 2010, Bioorganic & medicinal chemistry.

Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity

Ayako Nishimoto, Nobuyuki Ishikura, H. Kawata, 2010, The Prostate.

CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells.

R. Vessella, E. Corey, T. Shiraishi, 2015, International journal of oncology.

Biological properties of androgen receptor pure antagonist for treatment of castration‐resistant prostate cancer: Optimization from lead compound to CH5137291

T. Shiraishi, Ayako Nishimoto, Nobuyuki Ishikura, 2011, The Prostate.