Si Chen

Lei Guo, N. Mei, K. Witt, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes.

Lei Guo, M. Ceckova, F. Staud, 2019, Molecular pharmaceutics.

Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells

F. Beland, Yuanfeng Wu, Jia-Long Fang, 2014, Archives of Toxicology.

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Lei Guo, B. Ning, Qiangen Wu, 2018, Archives of Toxicology.

The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells.

Lei Guo, N. Mei, K. Witt, 2021, Toxicology letters.

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors

Lei Guo, B. Andresen, Ying Huang, 2019, PloS one.

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA.

Lei Guo, B. Ning, Dianke Yu, 2020, Methods in molecular biology.

Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan.

F. Beland, Yuanfeng Wu, Jia-Long Fang, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.

Lei Guo, N. Mei, B. Ning, 2021, Journal of environmental science and health. Part C, Toxicology and carcinogenesis.

Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance.

Lei Guo, J. Hofman, Si Chen, 2021, Chemico-biological interactions.

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

W. Tong, Lei Guo, B. Ning, 2020, Archives of Toxicology.

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Lei Guo, B. Ning, Qiangen Wu, 2018, Archives of Toxicology.

In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells

Lei Guo, S. Choudhuri, F. Beland, 2021, Food and Chemical Toxicology.

Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review.

W. Tong, Lei Guo, Joshua Xu, 2022, Regulatory toxicology and pharmacology : RTP.

Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells

N. Mei, M. Manjanatha, Xiaoqing Guo, 2022, Journal of applied toxicology : JAT.

MicroRNA hsa‐miR‐370‐3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

Tieliu Shi, W. Tong, Lei Guo, 2017, Biochemical pharmacology.

Autophagy in drug-induced liver toxicity

Lei Guo, Yuanfeng Wu, Si Chen, 2014, Journal of food and drug analysis.

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells.

Leming Shi, Lei Guo, B. Ning, 2017, Toxicology.

Genotoxicity evaluation of nutraceuticals

Lei Guo, N. Mei, Xiaoqing Guo, 2021 .

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells.

Lei Guo, N. Mei, S. Dial, 2015, Chemico-biological interactions.

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

W. Xiao, W. Tong, Lei Guo, 2019, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.

Huixiao Hong, Si Chen, Lei Guo, 2015, Biomarkers in medicine.

Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements**The information in this chapter is not a formal dissemination of information by the US Food and Drug Administration and does not represent agency position or policy.

Lei Guo, N. Mei, Si Chen, 2016 .

MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes.

B. Ning, Dianke Yu, Yongli Guo, 2016, Biochemical pharmacology.

MicroRNA-Dependent Gene Regulation of the Human Cytochrome P450

W. Xiao, W. Tong, Lei Guo, 2019, Pharmacoepigenetics.

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.

Lei Guo, B. Ning, J. Xuan, 2016, Chemico-biological interactions.

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene.

Lei Guo, N. Mei, B. Ning, 2020, Methods in molecular biology.

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

Lei Guo, N. Mei, J. Xuan, 2015, Scientific Reports.

DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

Lei Guo, B. Ning, Dianke Yu, 2018, Environmental and molecular mutagenesis.

The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells

Lei Guo, N. Mei, J. Bonzo, 2022, Journal of environmental science and health. Part C, Toxicology and carcinogenesis.

ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

Lei Guo, N. Mei, Xiaoqing Guo, 2018, Archives of Toxicology.

Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

Lei Guo, B. Ning, Si Chen, 2018 .

Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing.

W. Tong, Lei Guo, B. Ning, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

W. Xiao, Tieliu Shi, Leming Shi, 2018, Archives of Toxicology.

Mechanism study of goldenseal-associated DNA damage

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicology letters.

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1

W. Tong, Lei Guo, B. Ning, 2017, Biochemical pharmacology.

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells.

Lei Guo, Jie Zhang, Albert P. Li, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells

F. Beland, Yuanfeng Wu, Jia-Long Fang, 2015, Archives of Toxicology.

Mechanisms of tolvaptan-induced toxicity in HepG2 cells.

Lei Guo, F. Beland, Yuanfeng Wu, 2015, Biochemical pharmacology.

Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline

Lei Guo, Feng Li, Zhen Ren, 2022, Archives of Toxicology.

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.

Lei Guo, B. Ning, Xiaoqing Guo, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity

Lei Guo, Si Chen, W. Melchior, 2014, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells.

F. Beland, Qiangen Wu, Jia-Long Fang, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice

Lei Guo, Jin Wang, M. Matzuk, 2021, Drug Metabolism and Disposition.

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

Lei Guo, E. Novotná, F. Staud, 2020, Cancers.

The expression, induction and pharmacological activity of CYP1A2 are post‐transcriptionally regulated by microRNA hsa‐miR‐132–5p

W. Tong, Lei Guo, N. Mei, 2017, Biochemical pharmacology.

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p Suppress Basal and Rifampicin-induced Expression of Human Sulfotransferase 2A1 (SULT2A1) by Facilitating mRNA Degradation.

W. Tong, Lei Guo, B. Ning, 2019, Biochemical pharmacology.

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

Leming Shi, Lei Guo, N. Mei, 2017, Archives of Toxicology.

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

Lei Guo, N. Mei, Yuanfeng Wu, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells.

Si Chen, Xilin Li, Yuxia Li, 2023, Archives of toxicology.

Sertraline induces endoplasmic reticulum stress in hepatic cells.

Lei Guo, J. Xuan, Quanzhen Li, 2014, Toxicology.

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.

Lei Guo, B. Ning, J. Xuan, 2016, Chemico-biological interactions.

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

W. Tong, Lei Guo, B. Ning, 2020, Archives of Toxicology.

Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells.

M. Manjanatha, Si Chen, Xilin Li, 2024, Toxicology letters.

Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.

R. Mittelstaedt, N. Mei, D. Keire, 2023, Regulatory toxicology and pharmacology : RTP.