J. Leu

发表

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

A small molecule inhibitor of inducible heat shock protein 70.

Amanda K. Frank, M. Murphy, D. George, 2009, Molecular cell.

Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation

R. Taub, J. Leu, M. A. Crissey, 2003, Molecular and Cellular Biology.

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

K. Wellen, R. Ahima, J. Baur, 2020, bioRxiv.

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

K. Wellen, R. Ahima, J. Baur, 2020, bioRxiv.

The tetramerization domain of p53 is required for efficient BAK oligomerization

Amanda K. Frank, M. Murphy, E. Pietsch, 2007, Cancer biology & therapy.

p53 Moves to Mitochondria: A Turn on the Path to Apoptosis

M. Murphy, D. George, J. Leu, 2004, Cell cycle.

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.

M. Murphy, D. George, J. Leu, 2013, Journal of liver.

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

M. Herlyn, Gao Zhang, Tian Tian, 2017, Oncotarget.

Kinase Regulation Kinase / Extracellular Signal-Regulated Mitogen-Activated Protein and β Mice with Defects in C / EBP Growth Factor Binding Protein 1-Deficient Response Posthepatectomy in Insulin-Like Impaired Hepatocyte DNA Synthetic

R. Taub, J. Leu, M. A. Crissey, 2002 .

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

M. Murphy, D. George, P. Pandey, 2011, Molecular Cancer Research.

Signaling and Regulation HSP 70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

M. Murphy, D. George, P. Pandey, 2011 .

P53 regulates cellular redox state, ferroptosis and metabolism

M. Murphy, D. George, J. Leu, 2021, Molecular & Cellular Oncology.

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.

G. Mills, A. Weeraratna, Yiling Lu, 2016, Cancer research.

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

D. Speicher, M. Murphy, D. George, 2020, Cancer Research.

Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice.

R. Taub, J. Leu, M. A. Crissey, 2003, The Journal of clinical investigation.

Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

R. Marmorstein, M. Murphy, D. George, 2014, PloS one.

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

M. Murphy, D. George, P. Dumont, 2003, Nature Genetics.

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

Patrick Dumont, M. Murphy, D. George, 2004, Nature Cell Biology.

Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-β Signals during Liver Regeneration*

M. Macías-Silva, R. Taub, Wei Li, 2002, The Journal of Biological Chemistry.

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

Michelle R. Campbell, M. Hollstein, D. Bell, 2016, Genes & development.

Transcriptional Up-regulation of the Delayed Early GeneHRS/SRp40 during Liver Regeneration

R. Taub, J. Leu, Yong Peng, 1998, The Journal of Biological Chemistry.

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals.

R Taub, K. Du, R. Taub, 1998, The Journal of biological chemistry.

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

M. Murphy, D. George, A. Kossenkov, 2020, Nature Communications.

Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria.

D. George, J. Leu, 2007, Genes & development.

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Jingjing Liu, Rugang Zhang, M. Murphy, 2018, Cancer research.

The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and Inflammation

Yan Zhou, M. Hollstein, K. Devarajan, 2011, Molecular and Cellular Biology.

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.

R. Ahima, M. Murphy, D. George, 2016, Cell reports.

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

M. Murphy, D. George, J. Leu, 2019, Proceedings of the National Academy of Sciences.

HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant Melanoma

A. Weeraratna, M. Murphy, D. George, 2021, Cancer research communications.

Liver‐specific and proliferation‐induced deoxyribonuclease I hypersensitive sites in the mouse insulin‐like growth factor binding protein‐1 gene

R. De Angelis, L. Greenbaum, K. Kovalovich, 1999, Hepatology.

A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

Roland L. Dunbrack, M. Herlyn, Gao Zhang, 2013, Molecular Cancer Research.

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

R. Marmorstein, M. Murphy, D. George, 2014, ACS chemical biology.

Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury

G. Ciliberto, R. Taub, J. Leu, 2001, Molecular and Cellular Biology.

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53

M. Murphy, D. George, J. Leu, 2020, Proceedings of the National Academy of Sciences.

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

M. Murphy, D. George, A. Kossenkov, 2020, Nature Communications.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

J. Karanicolas, Noam Auslander, M. Murphy, 2023, Cancer discovery.