S. Pepe

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Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

F. Rosenfeldt, S Pepe, F L Rosenfeldt, 2000, Heart, lung & circulation.

Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy

Michael T Ryan, Joseph J Smolich, Michael Lazarou, 2012, Proceedings of the National Academy of Sciences.

p38 Mitogen-activated protein kinase inhibition reduces inflammatory cytokines in a brain-dead transplant donor animal model.

F. Rosenfeldt, S. Pepe, T. Oto, 2009, Heart, lung & circulation.

Postnatal inflammation in ApoE-/- mice is associated with immune training and atherosclerosis.

M. Wallace, M. Cheung, K. R. Short, 2021, Clinical science.

Postnatal inflammation in Apoe−/− mice is associated with immune training and atherosclerosis

M. Wallace, M. Cheung, K. R. Short, 2021, bioRxiv.

(n-3) Long chain PUFA dose-dependently increase oxygen utilization efficiency and inhibit arrhythmias after saturated fat feeding in rats.

S. Pepe, P. McLennan, 2007, The Journal of nutrition.

Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure.

J. Hoheisel, M. Frohme, T. Eschenhagen, 2002, Biochemical and biophysical research communications.

PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH.

E. Lakatta, R. Hansford, N. Tsuchiya, 1999, American journal of physiology. Heart and circulatory physiology.

Mitochondrial Function In Ischaemia And Reperfusion Of The Ageing Heart

S. Pepe, 2000, Clinical and experimental pharmacology & physiology.

Glycogen synthase kinase-3 b mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

E. Olson, K. Fishbein, S. Sollott, 2018 .

Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial.

C. Brizard, I. Konstantinov, Y. D'udekem, 2013, The Journal of thoracic and cardiovascular surgery.

Endogenous cardiac opioids: enkephalins in adaptation and protection of the heart.

L. Delbridge, F. Rosenfeldt, D. Kaye, 2003, Heart, lung & circulation.

Dysfunctional ischemic preconditioning mechanisms in aging.

S. Pepe, 2001, Cardiovascular research.

Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes.

E. Lakatta, H. Spurgeon, A. Leaf, 1994, Proceedings of the National Academy of Sciences of the United States of America.

w 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca 2 + channels , cytosolic Ca 2 + , and contraction in adult rat cardiac myocytes ( patch-clamp recording / indo-1 fluorescence )

E. Lakatta, H. Spurgeon, S. Pepe, 2022 .

Mitochondrial Bioenergetics and Dysfunction in Failing Heart.

S. Pepe, F. Sheeran, 2017, Advances in experimental medicine and biology.

F. Rosenfeldt, J. Mariani, P. Nagley, 2009, Mechanisms of Ageing and Development.

Tolerance to ischemia and hypoxia is reduced in aged human myocardium.

F. Rosenfeldt, J. Mariani, P. Nagley, 2000, The Journal of thoracic and cardiovascular surgery.

Mechanism of Cardioprotective Effect of Orotic Acid

F. Rosenfeldt, R. Conyers, S. Pepe, 1998, Cardiovascular Drugs and Therapy.

High dietary sucrose triggers hyperinsulinemia, increases myocardial β-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery

X. Leverve, P. Gachon, Y. Boirie, 2006, Molecular and Cellular Biochemistry.

Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium.

J. Rydström, S. Pepe, F. Sheeran, 2010, Biochimica et biophysica acta.

COVID-19 and Heart, Lung and Circulation: Riding the 2020 Waves of Change in Australia & New Zealand✰

S. Pepe, Ann T. Gregory, A. Denniss, 2020, Heart, Lung and Circulation.

A Small Cohort Omega-3 PUFA Supplement Study: Implications of Stratifying According to Lipid Membrane Incorporation in Cardiac Surgical Patients.

L. Delbridge, Julian A. Smith, S. Pepe, 2017, Heart, lung & circulation.

Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats.

C. Curl, C. Huggins, L. Delbridge, 2016, American journal of physiology. Heart and circulatory physiology.

Weighing Up Fish and Omega-3 PUFA Advice with Accurate, Balanced Scales: Stringent Controls and Measures Required for Clinical Trials.

S. Pepe, P. McLennan, 2015, Heart, lung & circulation.

Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

C. Nalliah, J. Kalman, S. Harrap, 2017, Journal of molecular and cellular cardiology.

Pacemaker cell and atrial function: unravelling how calcium initiates and regulates the heart beat and how ionic dysfunction, 'channelopathies' and other membrane remodelling contribute to atrial fibrillation.

L. Delbridge, S. Pepe, 2007, Heart, lung & circulation.

Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate.

S. Pepe, F. Sheeran, 2006, Biochimica et biophysica acta.

Aging hearts and vessels: masters of adaptation and survival.

E. Lakatta, S. Pepe, 2005, Cardiovascular research.

Gaps between the Teeth of Cardiovascular Health Strategy.

S. Pepe, M. Cheung, 2017, Heart, lung & circulation.

Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression

L. Delbridge, F. Rosenfeldt, T. Pedrazzini, 2007, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice

L. Delbridge, A. Domenighetti, C. Huggins, 2003, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals.

K. Chien, J. Mariani, R. Hajjar, 2007, Journal of the American College of Cardiology.

Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats.

S. Pepe, P. McLennan, 1996, The Journal of nutrition.

Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure

Julie Angerosa, S. Pepe, M. Cheung, 2019, Oxidative medicine and cellular longevity.

Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure.

S. Pepe, F. Sheeran, 2016, American journal of physiology. Endocrinology and metabolism.

Mitochondrial Dynamics and Oxidative Stress Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure

S. Pepe, F. Sheeran, Salvatore Pepe, 2016 .

The challenge of cardiovascular gene therapy in humans

S. Pepe, 1998 .

Dietary Polyunsaturated Fatty Acids and Age‐Related Membrane Changes in the Heart

S. Pepe, 2007, Annals of the New York Academy of Sciences.

Omentin on a four-pronged fork: another reason why obesity erodes cardiovascular survival.

S. Pepe, 2014, Heart, lung & circulation.

Targeting impaired bioenergetics in heart failure

S. Pepe, F. Sheeran, 2021 .

Oxidation of myofibrillar proteins in human heart failure.

F. Di Lisa, S. Menazza, M. Canton, 2011, Journal of the American College of Cardiology.

Opposing effects of age and calorie restriction on molecular determinants of myocardial ischemic tolerance.

J. Peart, J. Headrick, L. S. See Hoe, 2012, Rejuvenation research.

Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes

S. Pepe, 2005, Experimental Gerontology.

Uridine preserves ATP during hypoxic perfusion of the rat heart

F. Rosenfeldt, S. Pepe, S. Richards, 1997 .

Coenzyme Q10 in cardiovascular disease.

H. Krum, F. Rosenfeldt, S. Marasco, 2007, Mitochondrion.

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue.

F. Rosenfeldt, M. Bailey, S. Marasco, 2005, The Journal of thoracic and cardiovascular surgery.

Coenzyme Q 10 in cardiovascular disease

H. Krum, F. Rosenfeldt, S. Marasco, 2007 .

The other second messenger gas: carbon monoxide signalling for myocardial protection?

S. Pepe, 2001, Heart, lung & circulation.

Ischemic preconditioning increases the bioavailability of cardiac enkephalins.

E. Lakatta, J. Caffrey, S. Pepe, 2005, American journal of physiology. Heart and circulatory physiology.

Cardioplegic Strategies for Calcium Control: Low Ca2+, High Mg2+, Citrate, or Na+/H+ Exchange Inhibitor HOE-642

F. Rosenfeldt, Y. Fukuhiro, S. Pepe, 2000, Circulation.

Cardioplegic Strategies for Calcium Control

F. Rosenfeldt, Y. Fukuhiro, S. Pepe, 2000 .

The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms.

R. Ritchie, O. Woodman, C. Qin, 2007, Antioxidants & redox signaling.

The clinical application of metabolic therapy for cardiovascular disease.

F. Rosenfeldt, S. Pepe, A. Hadj, 2007, Heart, lung & circulation.

Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy.

F. Rosenfeldt, D. Esmore, S. Pepe, 2006, Heart, lung & circulation.

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure

H. Krum, F. Rosenfeldt, S. Pepe, 2003, BioFactors.

The principles of metabolic therapy for heart disease.

F. Rosenfeldt, S. Marasco, S. Pepe, 2003, Heart, lung & circulation.

Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice.

L. Delbridge, C. Curl, C. Huggins, 2009, American journal of physiology. Heart and circulatory physiology.

Preserved Left Ventricular Function despite Myocardial Fibrosis and Myopathy in the Dystrophin-Deficient D2.B10-Dmdmdx/J Mouse

Julie Angerosa, Jason D. White, S. Pepe, 2022, Oxidative medicine and cellular longevity.

Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial.

F. Rosenfeldt, M. Bailey, S. Marasco, 2010, Heart, lung & circulation.

Targeting oxidative stress in surgery: Effects of ageing and therapy

F. Rosenfeldt, S. Marasco, A. Perkins, 2008, Experimental Gerontology.

The publication rate and impact of abstracts presented at the Cardiac Society of Australia and New Zealand (1999-2005).

F. Rosenfeldt, S. Pepe, V. Chand, 2008, Heart, lung & circulation.

Reperfusion‐induced myocardial dysfunction is prevented by endogenous annexin‐A1 and its N‐terminal‐derived peptide Ac‐ANX‐A12‐26

E. Morand, R. Ritchie, D. Kaye, 2013, British journal of pharmacology.

Remote ischaemic preconditioning modifies serum apolipoprotein D, met‐enkephalin, adenosine, and nitric oxide in healthy young adults

I. Konstantinov, Julie Angerosa, S. Pepe, 2019, Clinical and experimental pharmacology & physiology.

Vascular Ageing: A Key Frontier in the Fight Against Cardiovascular Disease.

J. Mynard, S. Pepe, R. Climie, 2021, Heart, lung & circulation.

Cardiac reanimation for donor heart transplantation after cardiocirculatory death.

F. Rosenfeldt, S. Pepe, C. Mclean, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: Studies in rats and in human atrial tissue

F. Rosenfeldt, J. Mariani, P. Nagley, 1999, BioFactors.

Increased myocardial methionine‐enkephalin with reduced arterial oxygenation in congenital heart disease

F. Rosenfeldt, D. Penny, A. Cochrane, 2014, Journal of paediatrics and child health.

Effect of Remote Ischemic Preconditioning on Phosphorylated Protein Signaling in Children Undergoing Tetralogy of Fallot Repair: A Randomized Controlled Trial

Matthew S. Yong, I. Konstantinov, Y. D'udekem, 2013, Journal of the American Heart Association.

Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination

S. Pepe, Ann T. Gregory, A. Denniss, 2021, Heart, Lung and Circulation.

Feeding the Need: Cardiovascular Science in "Heart Lung and Circulation".

S. Pepe, 2016, Heart, lung & circulation.

Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells.

E. Lakatta, H. Spurgeon, M. Capogrossi, 1997, The American journal of physiology.

Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium.

M. Cheung, J. Peart, J. Headrick, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Letter to the Editor: 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP

Brian J. Smith, A. McLennan, J. Fletcher, 2005, Journal of biomolecular NMR.

A maintained afterload model of ischemia in erythrocyte-perfused isolated working hearts.

S. Pepe, P. McLennan, 1993, Journal of pharmacological and toxicological methods.

Response of the Senescent Heart to Stress: Clinical Therapeutic Strategies and Quest for Mitochondrial Predictors of Biological Age

F. Rosenfeldt, S. Marasco, P. Nagley, 2004, Annals of the New York Academy of Sciences.

Raising the Dead: Mitochondrial Cardiolipin as a Key Target for Post-Cardiac Arrest Resuscitation, Ischaemia-Reperfusion Injury and Cardiomyopathy.

S. Pepe, 2019, Heart, lung & circulation.

Safety of Intracoronary Human Cord Blood Stem Cells in a Lamb Model of Infant Cardiopulmonary Bypass.

C. Brizard, Julie Angerosa, J. Smolich, 2015, The Annals of thoracic surgery.

Aging and Dietary Lipids Modulate Ca2+-Dependent Mitochondrial Function in the Post-Ischemic Heart

S. Pepe, 2003 .

Neonatal Subcutaneous BCG Vaccination Decreases Atherosclerotic Plaque Number and Plaque Macrophage Content in ApoE−/− Mice

M. Wallace, Claudia A. Nold-Petry, D. Burgner, 2022, Biology.

Molecular basis of heart disease: A companion to Braunwald's heart disease: Edited by Kenneth R. Chien, 592 pages, 160 illustrations. WB Saunders Company, 1999. ISBN 0 7216 64016

S. Pepe, 2000 .

Benchmarking ventricular arrhythmias in the mouse--revisiting the 'Lambeth Conventions' 20 years on.

L. Delbridge, C. Huggins, J. Bell, 2008, Heart, lung & circulation.

The old heart: operating on the edge.

S. Sollott, E. Lakatta, S. Pepe, 2001, Novartis Foundation symposium.

Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.

E. Lakatta, H. Spurgeon, J. Caffrey, 2000, American journal of physiology. Heart and circulatory physiology.

F. Rosenfeldt, S. Marasco, S. Pepe, 2001, Asia Pacific journal of clinical nutrition.

What is the role of leukocyte depletion in cardiac surgery?

F. Rosenfeldt, R. Salamonsen, S. Pepe, 2007, Heart, lung & circulation.

Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart.

E. Lakatta, S. Pepe, R. Xiao, 2004, Cardiovascular research.

Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

E. Olson, K. Fishbein, S. Sollott, 2004 .

Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period

A. Oshlack, B. Phipson, J. Smolich, 2018, PloS one.

The challenge of improving donor heart preservation.

F. Rosenfeldt, D. Esmore, S. Pepe, 2004, Heart, lung & circulation.

Evaluating RNA preparation options for archived myocardial biopsies.

L. Delbridge, C. Huggins, S. Pepe, 2011, Heart, lung & circulation.

Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

Peter L McLennan, S. Pepe, Salvatore Pepe, 2002, Circulation.

Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.

E. Olson, K. Fishbein, S. Sollott, 2004, The Journal of clinical investigation.

[Gingival hyperplasia induced by amlodipine].

S. Pepe, L. Salerno, D. Gullotti, 1995, La Clinica terapeutica.

Protective role of Coenzyme Q10 in two models of rat lung injury

F. Rosenfeldt, S. Marasco, S. Pepe, 2010, ANZ journal of surgery.

Developing stem cell therapeutics for the heart also requires targeting non-myocytes.

C. Brizard, S. Pepe, N. Elwood, 2013, Heart, lung & circulation.

Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

J. Balligand, C. Dessy, E. Marbán, 2001, Nature Cell Biology.

Mitochondria "muscle in" as a potential adjunct therapy in cardiothoracic surgery.

S. Pepe, 2017, The Journal of thoracic and cardiovascular surgery.

Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

J. Peart, J. Headrick, I. Niesman, 2014, Experimental Gerontology.

Perinatal inflammation: a common factor in the early origins of cardiovascular disease?

M. Wallace, D. Burgner, T. Moss, 2015, Clinical science.

Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy

Xenia Dennett, F. Rosenfeldt, A. Mijch, 2005, International journal of STD & AIDS.

Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention.

G K Smyth, L. Delbridge, G. Smyth, 2008, Journal of molecular and cellular cardiology.

Cell-permeable protein therapy for complex I dysfunction

R. Gottlieb, R. Mentzer, S. Pepe, 2014, Journal of Bioenergetics and Biomembranes.

Coenzyme Q10 Protects the Aging Heart against Stress

Ruchong Ou, Silvana Marasco, F. Rosenfeldt, 2002, Annals of the New York Academy of Sciences.

Modulation of myocardial oxygen requirements by dietary lipids in the isolated erythrocyte perfused working rat heart

S. Pepe, P. McLennan, 1992 .

Mitochondria in heart ischaemia and aging.

R. Hansford, N. Tsuchiya, S. Pepe, 1999, Biochemical Society Symposium.

Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE-/- mice.

M. Wallace, M. Cheung, D. Burgner, 2019, Clinical science.

A switch in mechanism of action prevents doxorubicin-mediated cardiac damage.

A. Nudelman, S. Cutts, A. Rephaeli, 2021, Biochemical pharmacology.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Mitochondrial DNA deletions in human cardiac tissue show a gross mosaic distribution.

F. Rosenfeldt, P. Nagley, S. Pepe, 1999, Biochemical and biophysical research communications.

Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HIV patients.

S. Wesselingh, C. Cherry, A. Friedhuber, 2010, Mitochondrion.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

Arterial Stiffness in Congenital Heart Disease.

M. Cheung, J. Mynard, J. Smolich, 2021, Heart, lung & circulation.

'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart.

E. Lakatta, S. Pepe, R. Xiao, 1997, Circulation.

Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022)

A. Gunn, L. Bennet, A. Malhotra, 2023, Pediatric Research.

Cell, Gene and Regenerative Therapies in Cardiovascular Disease: Charting a Course From the Research Bench to Clinical Utility.

E. Kizana, James J. H. Chong, S. Pepe, 2023, Heart, lung & circulation.

Emerging Roles of Artificial Intelligence (AI) in Cardiology: Benefits and Barriers in a 'Brave New World'.

S. Pepe, N. Bart, A. Denniss, 2023, Heart, lung & circulation.

Molecular markers of programmed cell death in donor hearts before transplantation.

S. Marasco, S. Pepe, M. Vale, 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Safety and Feasibility of Adjunct Autologous Cord Blood Stem Cell Therapy During the Norwood Heart Operation.

C. Brizard, D. Zannino, W. Butt, 2023, The Journal of thoracic and cardiovascular surgery.

High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemia.

G. Snell, F. Rosenfeldt, S. Pepe, 2006, The Journal of thoracic and cardiovascular surgery.

Complex regional pain syndrome and methionine-enkephalin.

F. Rosenfeldt, S. Marasco, D. Esmore, 2006, Clinical chemistry.

MicroRNAs in heart, lung and circulation (and beyond): life's ubiquitous code for regulating complex function.

S. Pepe, 2012, Heart, lung & circulation.