E. Szegezdi

发表

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Involvement of planned cell death of necroptosis in cancer treatment by nanomaterials: Recent advances and future perspectives

A. Saboury, M. Sharifi, M. Falahati, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Synthetic constrained peptide selectively binds and antagonizes death receptor 5

W. Quax, Afshin Samali, R. Setroikromo, 2010, The FEBS journal.

Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells

D. Mahalingam, M. Keane, Afshin Samali, 2010, British Journal of Cancer.

The Janus Face of Death Receptor Signaling during Tumor Immunoediting

S. Logue, E. Szegezdi, Eimear O’ Reilly, 2016, Front. Immunol..

Caspase-12 and ER-stress-mediated apoptosis: the story so far.

Afshin Samali, U. Fitzgerald, E. Szegezdi, 2003, Annals of the New York Academy of Sciences.

NOXA contributes to the sensitivity of PERK‐deficient cells to ER stress

Z. Giricz, Sanjeev Gupta, Afshin Samali, 2012, FEBS letters.

Caspase‐12 and ER‐Stress‐Mediated Apoptosis

Afshin Samali, U. Fitzgerald, E. Szegezdi, 2003 .

University of Groningen Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity Szegezdi,

G. Montoya, I. Muñoz, D. Mahalingam, 2012 .

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL*

S. de Jong, G. Montoya, W. Quax, 2012, Molecular & Cellular Proteomics.

Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease

Pilib Ó Broin, P. Krebs, P. Nicholson, 2022, bioRxiv.

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death

C. Benedict, T. Gharbi, C. Garrido, 2017, Cell Death & Differentiation.

Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation

Janice L. V. Reeve, H. Fearnhead, Afshin Samali, 2007, Apoptosis.

Macromolecular crowding in the development of a three-dimensional organotypic human breast cancer model.

D. Zeugolis, U. Fitzgerald, E. Szegezdi, 2022, Biomaterials.

Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

Janice L. V. Reeve, Afshin Samali, S. Logue, 2007, Journal of cellular and molecular medicine.

Hypoxia and Ischemia Induce Nuclear Condensation and Caspase Activation in Cardiomyocytes

Afshin Samali, S. Logue, U. Fitzgerald, 2003, Annals of the New York Academy of Sciences.

Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells.

Afshin Samali, A. Gorman, E. Szegezdi, 2005, Biochemical and biophysical research communications.

Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia

C. Ortutay, Pramath Kakodkar, E. Szegezdi, 2020, Cancers.

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization

C. Holmberg, L. Sistonen, C. Concannon, 2005, Cell stress & chaperones.

ER stress contributes to ischemia-induced cardiomyocyte apoptosis.

Afshin Samali, S. Logue, A. Duffy, 2006, Biochemical and biophysical research communications.

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines

D. Mahalingam, G. Pirianov, H. Mehmet, 2009, British Journal of Cancer.

Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence

M. Tarunina, E. Szegezdi, Y. Choo, 2021, Frontiers in Cell and Developmental Biology.

Theranostic drug test incorporating the bone‐marrow microenvironment can predict the clinical response of acute myeloid leukaemia to chemotherapy

D. Zeugolis, M. Cahill, J. Krawczyk, 2020, British journal of haematology.

An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro.

Afshin Samali, M. Tuohy, B. Mulloy, 2011, Journal of natural products.

Concurrent transposon engineering and CRISPR/Cas9 genome editing of primary CLL-1 chimeric antigen receptor-natural killer cells.

N. Otto, M. Gurney, J. Krawczyk, 2022, Cytotherapy.

Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim

E. Kavanagh, Afshin Samali, E. Szegezdi, 2008, Journal of cellular and molecular medicine.

12 Cytokine-Induced-Cell Stress and Death in Type 1 Diabetes Mellitus

Afshin Samali, R. Jäger, C. Holohan, 2012 .

Correction to An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro

Afshin Samali, M. Tuohy, B. Mulloy, 2012 .

Editorial: Death Receptors, Non-apoptotic Signaling Pathways and Inflammation

E. Szegezdi, P. Legembre, 2020, Frontiers in Immunology.

TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems

E. Szegezdi, Hojjat Alizadeh Zeinabad, 2022, Cancers.

Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL

Afshin Samali, T. Ritter, C. Holohan, 2007, Journal of cellular and molecular medicine.

Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease

P. Krebs, P. Nicholson, A. Conforte, 2022, bioRxiv.

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL

C. Concannon, Afshin Samali, A. Gorman, 2006, Apoptosis.

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

G. Campiani, S. Butini, D. Williams, 2016, International journal of oncology.

Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

Sanjeev Gupta, Sandra Healy, Afshin Samali, 2010, International journal of cell biology.

Natural killer cell-mimic nanoparticles can actively target and kill acute myeloid leukemia cells

P. Krebs, Y. Banz, M. Lomora, 2022, bioRxiv.

CyBorD-DARA in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Results from the 16-BCNI-001/CTRIAL-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment.

S. Naicker, M. Cahill, J. Krawczyk, 2021, Clinical lymphoma, myeloma & leukemia.

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

R. Shivakumar, T. Mutis, M. Gurney, 2020, Haematologica.

Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.

A. Thompson, E. Szegezdi, S. P. S. Dhami, 2016, Drug discovery today.

Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling.

Sandra Healy, Afshin Samali, E. Szegezdi, 2013, Pharmacology & therapeutics.

Mediators of endoplasmic reticulum stress‐induced apoptosis

Afshin Samali, S. Logue, A. Gorman, 2006, EMBO reports.

Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.

P. O’Reilly, E. Venturini, M. Zoratti, 2014, Current pharmaceutical design.

Guiding the Killer and Bringing in Accomplices: Bispecific Antibody Treatment for Malignant Melanoma.

M. Leverkus, E. Szegezdi, 2016, The Journal of investigative dermatology.

G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis

M. P. Carty, Afshin Samali, M. O'Dwyer, 2015 .

The mitochondrial death pathway: a promising therapeutic target in diseases

B. Joseph, Sanjeev Gupta, G. Kass, 2009, Journal of cellular and molecular medicine.

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

C. Ortutay, Afshin Samali, C. Santocanale, 2018, Scientific Reports.

Bcl-2 family on guard at the ER.

Sanjeev Gupta, Afshin Samali, T. Ní Chonghaile, 2009, American journal of physiology. Cell physiology.

Hematopoietic versus leukemic stem cell quiescence: Challenges and therapeutic opportunities.

E. Szegezdi, Hojjat Alizadeh Zeinabad, Eimear O'Reilly, 2021, Blood reviews.

and Synthesis of Bim nur77 Both DNA Binding of Negative Selection of Thymocytes by Inhibiting Regulates α Ligation of Retinoic Acid Receptor

U. Reichert, L. Fésüs, Z. Szondy, 2012 .

Ligation of Retinoic Acid Receptor α Regulates Negative Selection of Thymocytes by Inhibiting Both DNA Binding of nur77 and Synthesis of Bim1

U. Reichert, L. Fésüs, Z. Szondy, 2003, The Journal of Immunology.

Decoy receptors block tumour cell eradication by TRAIL

E. Szegezdi, 2012 .

Cell Death in HIV Pathogenesis and Its Modulation by Retinoids

U. Reichert, L. Fésüs, P. Ancian, 2001, Annals of the New York Academy of Sciences.

Inhibition of IRE1α RNase activity sensitizes patient‐derived acute myeloid leukaemia cells to proteasome inhibitors

C. Richardson, R. Clifford, K. Mnich, 2022, Journal of cellular and molecular medicine.

Targeting TRAIL towards the clinic.

E. D. de Vries, S. de Jong, F. Giles, 2011, Current drug targets.

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

S. de Jong, D. Mahalingam, M. Keane, 2009, Cancer treatment reviews.

Recreating complex pathophysiologies in vitro with extracellular matrix surrogates for anticancer therapeutics screening.

Abhay Pandit, Dimitrios I Zeugolis, Eva Szegezdi, 2016, Drug discovery today.

BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1.

Sanjeev Gupta, Afshin Samali, S. Logue, 2015, Biochemical and biophysical research communications.

Stem cells are resistant to TRAIL receptor-mediated apoptosis

M. Murphy, H. Mehmet, Afshin Samali, 2008, Journal of cellular and molecular medicine.

Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells

Zsuzsa Szondy, Zsolt Sarang, Mauro Piacentini, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells

J. Krawczyk, M. O'Dwyer, E. Szegezdi, 2014, Leukemia research reports.

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

C. Pellat-deceunynck, C. Garrido, Patrick Legembre, 2016, Oncotarget.

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants

F. Stricher, W. Quax, A. M. van der Sloot, 2010, Cell Death and Disease.

Activation‐induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor α and γ and involve nur77 in T cells

U. Reichert, L. Fésüs, P. Ancian, 2001, European journal of immunology.

Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)‐mediated apoptosis in activation‐induced T cell death involves calcineurin and protein kinase C, respectively

J. Lord, G. Molnár, L. Fésüs, 1999, European journal of immunology.

Retinoid receptor‐activating ligands are produced within the mouse thymus during postnatal development

Zsuzsa Szondy, Ralph Rühl, Judit Pongrácz, 2008, European journal of immunology.

The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis

Eva Szegezdi, Eoin Murphy, Afshin Samali, 2011, Cancers.

TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt

Afshin Samali, M. O'Dwyer, E. Szegezdi, 2006, British Journal of Cancer.

DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design*

W. Quax, A. M. van der Sloot, Afshin Samali, 2008, Journal of Biological Chemistry.

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor.

Almer M van der Sloot, Eva Szegezdi, W. Quax, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy

P. O’Reilly, C. Ortutay, C. Seoighe, 2014, BMC Genomics.

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

Afshin Samali, E. Szegezdi, M. van Dijk, 2013, Cell Death and Disease.

Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand Resistance?

Afshin Samali, L. Egan, E. Szegezdi, 2009 .

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

W. Quax, A. M. van der Sloot, Afshin Samali, 2009, Biochemistry.

Molecular targets for novel drug development in pancreatic cancer

C. Santocanale, E. Szegezdi, Eimear O'Reilly, 2015 .

Targeting AML through DR4 with a novel variant of rhTRAIL

Janice L. V. Reeve, W. Quax, A. M. van der Sloot, 2011, Journal of cellular and molecular medicine.

Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment

Mary Murphy, Eva Szegezdi, Frank Barry, 2008, Stem cells.

Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter

Z. Nemes, L. Fésüs, L. Nagy, 2000, Cell Death and Differentiation.

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity

W. Quax, A. M. van der Sloot, Afshin Samali, 2016, Oncogene.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death

C. Benedict, T. Gharbi, C. Garrido, 2017, Cell Death and Differentiation.

Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia

Pilib Ó Broin, P. Krebs, P. Nicholson, 2023, iScience.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

Tc Buster Transposon Engineered CLL-1 CAR-NK Cells Efficiently Target Acute Myeloid Leukemia

R. Childs, M. Gurney, J. Krawczyk, 2021, Blood.

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML

C. Ortutay, Afshin Samali, C. Santocanale, 2018, Scientific Reports.

Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing.

E. Szegezdi, M. Watters, 2017, Bio-protocol.

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL

F. Stricher, Afshin Samali, K. Sjollema, 2019 .

Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.

Arvind Negi, Afshin Samali, Jian Zhou, 2015, Organic letters.

TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

G. Karakülah, A. Conforte, E. Szegezdi, 2023, bioRxiv.

Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy

C. Ortutay, C. Seoighe, E. Szegezdi, 2014, BMC Genomics.