M. Zimmerman

发表

Protein-tyrosine Phosphatase 4A3 (PTP4A3) Promotes Vascular Endothelial Growth Factor Signaling and Enables Endothelial Cell Motility*

G. Homanics, J. Lazo, B. Pitt, 2014, The Journal of Biological Chemistry.

Ex Vivo and In Vivo Assessments of Angiogenesis, Blood Flow and Vasoactive Capability

N. Rogers, D. Roberts, J. Isenberg, 2012 .

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.

Richard A. Young, R. Young, A. Look, 2018, Cancer discovery.

Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights

B. Abraham, Adam D. Durbin, M. Zimmerman, 2022, Cell reports. Medicine.

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

R. Young, A. Look, K. Stegmaier, 2022, bioRxiv.

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors

A. Look, Shuning He, N. Prutsch, 2022, bioRxiv.

PTP4A3 phosphatase promotes VEGF signaling and enables endothelial cell motility

G. Homanics, J. Lazo, B. Pitt, 2013 .

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

M. Bulyk, A. Look, K. Stegmaier, 2021, Cancer discovery.

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

Daniel‐Adriano Silva, W. Klapper, P. Gaulard, 2021, Nature Communications.

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

R. Young, A. Look, J. Maris, 2019, Nature Communications.

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

A. Look, J. Epstein, Shuning He, 2016, eLife.

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

F. Speleman, K. De Preter, B. Abraham, 2021, Cancers.

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

Colin J. Daniel, Ellen M. Langer, R. Sears, 2021, Nature Chemical Biology.

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

John T. Powers, R. Young, K. Ross, 2020, Proceedings of the National Academy of Sciences.

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

K. Ross, A. Look, J. Aster, 2019, PLoS genetics.

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

A. Look, T. Tao, B. Abraham, 2020, Science Advances.

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

R. Young, T. Golub, W. Hahn, 2018, Nature Genetics.

Targeted deletion of Ptp4a3 inhibits colon carcinogenesis and angiogenesis

M. Zimmerman, Mark W. Zimmerman, 2013 .

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

Traci M. Blonquist, R. Young, L. Zon, 2018, The Journal of experimental medicine.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Hu Li, D. Neuberg, A. Look, 2017, Cancer cell.

Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish.

A. Look, M. Zimmerman, R. Stewart, 2016, Methods in cell biology.

Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

R. Young, A. Look, Shuning He, 2021, bioRxiv.

Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN

R. Young, A. Look, Shuning He, 2020 .

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

A. Look, N. Gray, Jinhua Wang, 2020, Cell.

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

K. Ross, A. Look, J. Aster, 2020, Disease Models & Mechanisms.

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

F. Speleman, M. Fischer, R. Versteeg, 2023, Nature Communications.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

R. Young, J. Joung, J. Maris, 2023, bioRxiv.

Title: c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification Authors:

R. Young, A. Look, Beisi Xu, 2017 .

Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer

G. Homanics, J. Lazo, M. Zimmerman, 2013, PloS one.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

T. Aittokallio, S. Mustjoki, T. Haferlach, 2022, bioRxiv.

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

L. Zon, C. Kaufman, A. Look, 2021, Oncogene.

Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.

G. Homanics, J. Lazo, M. Zimmerman, 2014, Stem cell research.

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

R. Young, T. Golub, W. Hahn, 2018, Nature Genetics.

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

R. Young, J. Joung, J. Maris, 2023, The Journal of clinical investigation.

Supplemental Methods PCR analysis on genomic translocations Genomic

R. Young, A. Look, Beisi Xu, 2017 .

Synthetic lethal targeting of TET2‐mutant haematopoietic stem and progenitor cells by XPO1 inhibitors

Shuning He, N. Prutsch, Y. Landesman, 2023, British journal of haematology.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Hu Li, D. Neuberg, A. Look, 2017, Cancer cell.