K. Natarajan

发表

Role of Breast Cancer Resistance Protein (BCRP, ABCG2) in Cancer Outcomes and Drug Resistance

D. Ross, M. Baer, K. Natarajan, 2015 .

Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1.

W. T. Beck, D. Ross, K. Bauer, 2013, Biochimica et biophysica acta.

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance.

D. Ross, M. Baer, Douglas D Ross, 2012, Biochemical pharmacology.

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

S. Ambudkar, S. Shukla, M. Baer, 2015, Investigational New Drugs.

The FLT3 Inhibitor Quizartinib Inhibits ABCG2 at Pharmacologically Relevant Concentrations, with Implications for Both Chemosensitization and Adverse Drug Interactions

S. Ambudkar, S. Shukla, M. Baer, 2013, PloS one.

Preclinical Development The Novel BCR-ABL and FLT 3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG 2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012 .

The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012, Molecular Cancer Therapeutics.

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents.

B. Aggarwal, K. Natarajan, S. Singh, 1996, Journal of immunology.

Toxicokinetic Study of Recombinant Human Heparin-Binding Epidermal Growth Factor-Like Growth Factor (rhHB-EGF) in Female Sprague Dawley Rats

T. Garimella, K. Bauer, S. Keay, 2008, Pharmaceutical Research.

Antioxidant and protective effects of Amrit Nectar tablets on adriamycin- and cisplatin-induced toxicities.

C. Dwivedi, H. Sharma, K. Natarajan, 2005, Journal of alternative and complementary medicine.

Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-κB, degradation of IκBα, nuclear translocation of p65, and subsequent gene expression

S. Manna, B. Aggarwal, M. Chaturvedi, 1998 .

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

B. Aggarwal, T. Burke, Sanjaya Singh, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication

Y. Qiu, M. Baer, K. Natarajan, 2013, PloS one.

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

A. Tron, D. Perrotti, R. Trotta, 2016, Oncotarget.

Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2

E. Sausville, A. Jaiswal, F. Rassool, 2016, Pharmaceuticals.

Tumor necrosis factors: developments during the last decade.

B. Aggarwal, B B Aggarwal, K. Natarajan, 1996, European cytokine network.

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.

R. Heller, B. Aggarwal, R. Heller, 1998, Journal of immunology.

Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation

A. Tron, D. Perrotti, R. Trotta, 2017, Clinical Cancer Research.

Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells.

A. Hamburger, D. Ross, T. Nakanishi, 2015, Biochimica et biophysica acta.

Chemopreventive Effects of Dietary Flaxseed Oil on Colon Tumor Development

C. Dwivedi, K. Natarajan, D. Matthees, 2005, Nutrition and cancer.

Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine.

W. T. Beck, D. Ross, K. Bauer, 2011, Biochimica et biophysica acta.

Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users

R. Lionberger, Liang Zhao, M. Kinjo, 2021, Clinical and translational science.

RDQN: ensemble of deep neural network with reinforcement learning in classification based on rough set theory for digital transactional fraud detection

K. Natarajan, Chandana Gouri Tekkali, 2023, Complex & Intelligent Systems.

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2013, Biochemical pharmacology.

Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.

S. Manna, B. Aggarwal, M. Chaturvedi, 1998, Archives of biochemistry and biophysics.

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

A. Tron, D. Perrotti, R. Trotta, 2016 .

In Silico Prediction of Alternative First Exons of Bcrp 1 Using BLAST Analysis of Mouse EST Database

D. Ross, T. Nakanishi, A. Hussain, 2017 .