N. Jonckheere

发表

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

E. Leteurtre, M. Hebbar, N. Skrypek, 2013, Oncogene.

Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.

I. van Seuningen, J. Lo-Guidice, C. Cauffiez, 2006, Birth defects research. Part A, Clinical and molecular teratology.

Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2α overexpression

G. Huet, I. van Seuningen, N. Saint-Laurent, 2009, British Journal of Cancer.

Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model

S. Msika, N. Kapel, M. le Gall, 2020, Scientific Reports.

A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms

S. Truant, L. weiswald, F. Escande, 2021, Biology of the cell.

Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22

J. Sirard, J. Renauld, P. Gosset, 2016, Infection and Immunity.

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

R. Losson, P. Dubus, M. Janier, 2012, The American journal of pathology.

Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

S. Truant, F. Pruvot, G. Huet, 2015, Cancer science.

Of autophagy and in vivo pancreatic carcinogenesis: the p53 status matters!

I. van Seuningen, A. Vincent, N. Jonckheere, 2014, Clinics and research in hepatology and gastroenterology.

The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor‐1 (TTF‐1) and GATA‐6 transcription factors

M. Copin, I. van Seuningen, N. Jonckheere, 2011, The FEBS journal.

The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells.

C. Mariette, G. Piessen, E. Leteurtre, 2014, Biochimica et biophysica acta.

Mg2+ Transporters in Digestive Cancers

P. Kischel, I. van Seuningen, P. Rybarczyk, 2021, Nutrients.

GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

E. Leteurtre, I. van Seuningen, A. Vincent, 2012, Biochimica et biophysica acta.

Targeting MUC4 in pancreatic cancer: miRNAs

I. van Seuningen, N. Jonckheere, F. Lahdaoui, 2015, Oncoscience.

The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells*

I. van Seuningen, M. Perrais, K. Carraway, 2007, Journal of Biological Chemistry.

Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells

I. van Seuningen, M. Perrais, R. Courcol, 2014, Gastric Cancer.

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.

I. van Seuningen, N. Porchet, F. Renaud, 2015, Biochimica et biophysica acta.

The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways

J. Merlin, P. Dumont, A. Harris, 2012, PloS one.

Mucins and tumor resistance to chemotherapeutic drugs.

I. van Seuningen, N. Skrypek, N. Jonckheere, 2014, Biochimica et biophysica acta.

Evaluation of the expression of fatty acid synthase and O-GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches

T. Lefebvre, P. Rybarczyk, Ninon Very, 2022, Oncology letters.

The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies.

I. van Seuningen, N. Jonckheere, 2008, Critical reviews in oncogenesis.

TRPM7 Modulates Human Pancreatic Stellate Cell Activation

P. Kischel, I. van Seuningen, H. Kocher, 2022, Cells.

Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells.

E. Leteurtre, I. van Seuningen, J. Torrisani, 2015, Biochimica et biophysica acta.

The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers.

I. van Seuningen, N. Jonckheere, 2010, Biochimie.

Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers.

I. van Seuningen, A. Vincent, N. Jonckheere, 2021, Biochimica et biophysica acta. Reviews on cancer.

A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-β in pancreatic carcinogenesis

S. Batra, C. Mariette, M. Perrais, 2004, Oncogene.

Long non-coding RNAs: the tentacles of chromatin remodeler complexes

I. van Seuningen, A. Vincent, N. Jonckheere, 2020, Cellular and Molecular Life Sciences.

Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers

A. Vincent, I. Seuningen, N. Jonckheere, 2020 .

Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer

I. van Seuningen, A. Vincent, N. Jonckheere, 2018, Cancers.

Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.

M. Copin, C. Mariette, G. Piessen, 2007, The Biochemical journal.

The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells.

I. van Seuningen, M. Perrais, P. Pigny, 2005, The Biochemical journal.

Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.

M. Sander, E. Mayes, X. Dai, 2008, Developmental biology.

The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein.

C. Mariette, I. van Seuningen, E. Bruyère, 2011, Biochemical and biophysical research communications.

The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.

I. van Seuningen, N. Jonckheere, R. Vasseur, 2017, Critical reviews in oncology/hematology.

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

I. van Seuningen, N. Skrypek, B. Duchêne, 2018, Cancers.

TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3

N. Skrypek, B. Duchêne, I. Seuningen, 2018, bioRxiv.

Membrane-bound mucin modular domains: from structure to function.

I. van Seuningen, N. Skrypek, N. Jonckheere, 2013, Biochimie.

EGF-containing Membrane-bound Mucins: a hidden ErbB2 targeting pathway?

I. van Seuningen, P. Melnyk, Maxime Liberelle, 2020, Journal of medicinal chemistry.

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.

S. Batra, C. Mariette, E. Leteurtre, 2004, The Biochemical journal.

miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer

C. Mariette, E. Leteurtre, J. Torrisani, 2014, Oncogene.

The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways.

I. van Seuningen, B. Duchêne, N. Jonckheere, 2015, Biochemical and biophysical research communications.

Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

S. Truant, F. Pruvot, G. Huet, 2010, Cancer research.

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

Romain Vasseur, I. van Seuningen, A. Vincent, 2015, Oncotarget.

Mucins and Pancreatic Cancer

I. van Seuningen, N. Skrypek, N. Jonckheere, 2010, Cancers.

Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines*

D. Silberg, I. van Seuningen, J. Serpa, 2003, Journal of Biological Chemistry.

Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model

S. Msika, N. Kapel, M. le Gall, 2020, Scientific Reports.

Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma

E. Leteurtre, I. van Seuningen, J. Torrisani, 2021, Cancers.

Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1.

H. Büller, A. Einerhand, I. van Seuningen, 2004, The Biochemical journal.

Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

I. van Seuningen, N. Jonckheere, 2014, Tumor Biology.

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas

I. van Seuningen, N. Jonckheere, 2018, Journal of Translational Medicine.

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway.

C. Mariette, G. Piessen, E. Leteurtre, 2017, The Biochemical journal.

Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival

V. Treviño, A. Vincent, I. Seuningen, 2020, Cancers.

Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?

P. Rybarczyk, H. Sevestre, L. Rodat-Despoix, 2022, International journal of molecular sciences.

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

X. Thuru, I. van Seuningen, P. Melnyk, 2021, Cancers.

The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.

H. Büller, A. Einerhand, I. van Seuningen, 2004, Biochemical and biophysical research communications.

Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells.

E. Leteurtre, I. van Seuningen, A. Vincent, 2015, Stem cell research.

Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required.

I. van Seuningen, N. Jonckheere, 2019, Annals of translational medicine.

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

B. Duchêne, I. Seuningen, N. Jonckheere, 2013, Oncogene.

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF- (cid:20) B and RalB signaling pathways

N. Porchet, B. Duchêne, I. Seuningen, 2020 .

Membrane-bound mucin modular domains: from structure to function.

I. van Seuningen, N. Jonckheere, F. Frénois, 2013, Biochimie.

Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

A. Dessein, N. Jonckheere, C. Do Cao, 2023, Frontiers in endocrinology.