G. Conseil

发表

Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells.

S. Cole, Md. Tozammel Hoque, G. Conseil, 2009, Biochemical and biophysical research communications.

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.

S. Cole, R. Deeley, G. Conseil, 2005, Pharmacogenetics and genomics.

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.

T. Krell, A. di Pietro, D. Barron, 2001, Biochemistry.

Functional expression of the human breast cancer resistance protein in Pichia pastoris.

S. Cole, J. Unadkat, Qingcheng Mao, 2004, Biochemical and biophysical research communications.

Chalcogenopyrylium Dyes as Differential Modulators of Organic Anion Transport by Multidrug Resistance Protein 1 (MRP1), MRP2, and MRP4

S. Cole, M. Detty, G. Conseil, 2013, Drug Metabolism and Disposition.

Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).

S. Cole, D. Clarke, T. W. Loo, 2012, Journal of medicinal chemistry.

N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity.

S. Cole, G. Conseil, M. F. Miah, 2016, Biochemical and biophysical research communications.

Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)

S. Cole, A. Rothnie, R. Deeley, 2009, Drug Metabolism and Disposition.

Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

R. Campbell, S. Cole, M. DeGorter, 2008, Biochemical and biophysical research communications.

Mechanistic Differences between GSH Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) and GSH Modulation of MRP1-Mediated Transport

S. Cole, A. Rothnie, R. Deeley, 2008, Molecular Pharmacology.

Identification of Proline Residues in the Core Cytoplasmic and Transmembrane Regions of Multidrug Resistance Protein 1 (MRP1/ABCC1) Important for Transport Function, Substrate Specificity, and Nucleotide Interactions*

S. Cole, K. Koike, R. Deeley, 2004, Journal of Biological Chemistry.

Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter.

S. Cole, G. Conseil, Emma E Smith, 2021, PloS one.

DMD054213 2187..2196

S. Cole, G. Conseil, 2013 .

Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport

Terri T. Ni, Bin Zhou, J. Schuetz, 2014, Nature Cell Biology.

Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4)

S. Cole, G. Conseil, Mark A Csandl, 2016, Drug Metabolism and Disposition.

Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.

A. Goffeau, A. di Pietro, D. Barron, 2000, Biochemistry.

Sex differences in the aging murine urinary bladder and influence on the tumor immune microenvironment of a carcinogen-induced model of bladder cancer

A. Hamade, M. Koti, G. Conseil, 2022, Biology of sex differences.

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

D. Cooper, A. Gudkov, J. Fletcher, 2014, Biochemical pharmacology.

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin.

J. M. Pérez-Victoria, A. di Pietro, D. Barron, 1999, Biochemistry.

GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators

J. Fletcher, S. Cole, M. Haber, 2021, The FEBS journal.

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancer

M. Köbel, M. Koti, G. Conseil, 2022, bioRxiv.

C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.

A. di Pietro, D. Barron, C. Dumontet, 2001, Journal of medicinal chemistry.

Prenylated xanthones as potential P-glycoprotein modulators.

A. di Pietro, D. Barron, G. Conseil, 2000, Bioorganic & medicinal chemistry letters.

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.

A. di Pietro, D. Barron, J. Jault, 1998, Proceedings of the National Academy of Sciences of the United States of America.

B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.

A. di Pietro, F. Bois, A. Boumendjel, 2001, Bioorganic & medicinal chemistry letters.

Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance.

A. di Pietro, F. Bois, A. Boumendjel, 1998, Journal of medicinal chemistry.

High-Affinity Binding of Silybin Derivatives to the Nucleotide-Binding Domain of a Leishmania tropicaP-Glycoprotein-Like Transporter and Chemosensitization of a Multidrug-Resistant Parasite to Daunomycin

J. M. Pérez-Victoria, A. di Pietro, D. Barron, 2001, Antimicrobial Agents and Chemotherapy.

The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.

A. di Pietro, D. Barron, K. El Kirat, 2000, Bioorganic & medicinal chemistry letters.

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

X. Le, S. Cole, M. Banerjee, 2016, Biochemical pharmacology.

Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa.

A. Mårtensson, S. Dahlström, H. Darban, 2009, The Journal of infectious diseases.

Functional Importance of Three Basic Residues Clustered at the Cytosolic Interface of Transmembrane Helix 15 in the Multidrug and Organic Anion Transporter MRP1 (ABCC1)*

S. Cole, R. Deeley, G. Conseil, 2006, Journal of Biological Chemistry.

Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas.

S. Cole, R. Deeley, G. Conseil, 2005, Biochemical pharmacology.

Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1

S. Cole, Susan P C Cole, G. Conseil, 2013, Drug Metabolism and Disposition.

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells.

J. Fletcher, S. Cole, M. Haber, 2019, Biochemical pharmacology.

S. Cole, R. Deeley, G. Conseil, 2004, Current drug metabolism.

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

J. M. Pérez-Victoria, A. di Pietro, S. Castanys, 2003, Cellular and Molecular Life Sciences CMLS.

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

A. Goffeau, J. M. Pérez-Victoria, A. di Pietro, 2002, Cellular and Molecular Life Sciences CMLS.

Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance.

F. Bois, A. Boumendjel, G. Conseil, 1999, Bioorganic & medicinal chemistry.

P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.

T. Krell, A. di Pietro, J. Jault, 1999, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1)

S. Cole, A. Rothnie, Y. Tsfadia, 2018, Molecular Pharmacology.

Mutational Analysis of Ionizable Residues Proximal to the Cytoplasmic Interface of Membrane Spanning Domain 3 of the Multidrug Resistance Protein, MRP1 (ABCC1)

S. Cole, Dawei Zhang, K. E. Sparks, 2004, Journal of Biological Chemistry.

Structure‐guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1)

S. Cole, Y. Tsfadia, G. Conseil, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model

D. Tieleman, V. Corradi, S. Cole, 2021, International journal of molecular sciences.

Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1).

S. Cole, R. Deeley, G. Conseil, 2004, Molecular pharmacology.

The influence of age and sex on the pre-treatment immune microenvironment of a carcinogen induced murine model of bladder cancer

A. Hamade, D. Siemens, M. Koti, 2021 .

Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

M. Koti, G. Conseil, K. Tyryshkin, 2023, Journal for ImmunoTherapy of Cancer.

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

A. di Pietro, C. Dumontet, G. Appendino, 2003, Journal of natural products.

Multiple Roles of Charged Amino Acids in Cytoplasmic Loop 7 for Expression and Function of the Multidrug and Organic Anion Transporter MRP1 (ABCC1)

S. Cole, A. Rothnie, R. Deeley, 2009, Molecular Pharmacology.

Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.

A. Goffeau, J. M. Pérez-Victoria, A. di Pietro, 2003, Biochimica et biophysica acta.

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.

A. Goffeau, J. M. Pérez-Victoria, A. di Pietro, 2001, Biochemistry.

Prenylated xanthones as potential P-glycoprotein modulators.

A. di Pietro, D. Barron, G. Conseil, 2000, Bioorganic & medicinal chemistry letters.

The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression

S. Cole, G. Conseil, 2021, International journal of molecular sciences.

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

M. Banerjee, E. Leslie, G. Conseil, 2016, Biochemical pharmacology.

N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity.

G. Conseil, Susan P.C. Cole, M. Fahad Miah, 2016, Biochemical and biophysical research communications.

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

A. Goffeau, J. M. Pérez-Victoria, D. Barron, 2002, Cellular and Molecular Life Sciences CMLS.

Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1

S. Cole, G. Conseil, 2013, Drug Metabolism and Disposition.