A. Fridland

发表

A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.

M. Connelly, B. Robbins, D. Marshall, 1995, Molecular pharmacology.

Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells

M. Connelly, B. Robbins, A. Fridland, 1995, Antimicrobial agents and chemotherapy.

A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients.

J. Rodman, P. Flynn, B. Robbins, 1996, The Journal of infectious diseases.

Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS.

A. Ray, A. Fridland, Jennifer E. Vela, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants.

J. F. Rodríguez, S. Blanchard, J. Rodman, 1999, The Journal of infectious diseases.

Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

S. Broder, M. Connelly, M. Johnson, 1988, The Journal of biological chemistry.

GS-9219 ! ANovel Acyclic NucleotideAnaloguewith Potent Antineoplastic Activity in Dogs with Spontaneous Non ^ Hodgkin ’ s Lymphoma

William A. Lee, Xiaohong Liu, M. Desai, 2010 .

Growth and Differentiation of a Human T-Cell Leukemia Cell Line , CCRF-CEM , Grafted in Mice 1

Joseph, S. Raimondi, P. Houghton, 2006 .

Comparative Studies of 2′,3′‐Didehydro‐2′,3′‐Dideoxythymidine (D4T) with other Pyrimidine Nucleoside Analogues

S. Kaul, A. Fridland, L. Dunkle, 1990, Annals of the New York Academy of Sciences.

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro.

S. Broder, C. Perno, M. Sarngadharan, 1988, Molecular pharmacology.

Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology

B. Robbins, A. Fridland, B. Waibel, 1996, Antimicrobial agents and chemotherapy.

Antiretroviral Activity of Carbocyclic Nucleosides and Potential Use of Inosinate Dehydrogenase Inhibitors

A. Fridland, L. L. Bondoc, 1991 .

Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells.

A. Fridland, J. Secrist, R. Vince, 1990, Biochemistry.

Modulation of metabolism and anti-HIV-1 activity of purine 2',3'-dideoxynucleosides by IMP dehydrogenase inhibitors.

B. Robbins, A. Fridland, H. Mitsuya, 1991, Advances in experimental medicine and biology.

Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.

M. Currens, D. Cooney, A. Fridland, 1990, Biochemical and biophysical research communications.

PART IV. BIOCHEMISTRY AND EVALUATION OF ANTI-HIV THERAPEUTICS

V. Marquez, J. Driscoll, D. Cooney, 2006 .

In Vitro Testing of Therapeutics against SIV and HIV

L. Resnick, R. Schinazi, K. Soike, 1990 .

Metabolism in Human Leukocytes of Anti‐HIV Dideoxypurine Nucleosides a

V. Marquez, J. Driscoll, D. Cooney, 1990, Annals of the New York Academy of Sciences.

Mechanism for ara-CTP catabolism in human leukemic cells and effect of deaminase inhibitors on this process.

A. Fridland, V. Verhoef, 1987, Seminars in oncology.

Lack of a Metabolic and Antiviral Drug Interaction between Tenofovir, Abacavir and Lamivudine

K. Borroto-Esoda, A. Ray, A. Fridland, 2005, Antiviral therapy.

A new sensitive cartridge-RIA method for determination of stavudine (D4T) triphosphate in human cells in vivo.

J. Grassi, B. Robbins, A. Fridland, 2003, Antiviral research.

Development of a New Cartridge Radioimmunoassay for Determination of Intracellular Levels of Lamivudine Triphosphate in the Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Patients

J. Grassi, B. Robbins, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.

Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.

S. Broder, D. Cooney, A. Fridland, 1991, Molecular pharmacology.

Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.

S. Broder, D. Cooney, A. Fridland, 1987, Biochemical pharmacology.

Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3'-azido-3'-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM).

R. Ashmun, M. Connelly, A. Fridland, 1990, Molecular pharmacology.

Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.

M. Connelly, R. V. Srinivas, A. Fridland, 1995, Molecular pharmacology.

Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells.

M. Connelly, B. Robbins, A. Fridland, 1993, Biochemical pharmacology.

2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy.

M. Johnson, A. Fridland, D. Johns, 1987, Biochemical and biophysical research communications.

Differences in Metabolism and Cytotoxicity between 9-β-d-Arabinofuranosyladenine and 9-β-d-Arabinofuranosyl-2-fluoroadenine in Human Leukemic Lymphoblasts

A. Fridland, L. Poulakos, L. Dow, 1980 .

Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.

M. Connelly, A. Fridland, V. Pisarev, 1997, Molecular pharmacology.

Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells

J. Rodman, P. Flynn, B. Robbins, 1994, Antimicrobial Agents and Chemotherapy.

Metabolism of Tenofovir and Didanosine in Quiescent or Stimulated Human Peripheral Blood Mononuclear Cells

J. Rodman, B. Robbins, A. Fridland, 2003, Pharmacotherapy.

Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts.

J. Ducore, A. Fridland, A. Look, 1983, Cancer research.

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

M. Connelly, B. Robbins, R. V. Srinivas, 1993, Antimicrobial Agents and Chemotherapy.

Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

B. Robbins, R. V. Srinivas, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.

Purification of thymidylate synthetase from Ehrlich ascites carcinoma cells.

C. Heidelberger, A. Fridland, R. Langenbach, 1971, The Journal of biological chemistry.

DNA precursors in eukaryotic cells.

A. Fridland, 1973, Nature: New biology.

Mode of action of 1-beta-D-arabinofuranosylcytosine in human lymphoblasts: differential effects of the drug on chromosomal replication.

A. Fridland, 1982, Medical and pediatric oncology.

Inhibition of DNA Synthesis by 1-β-D-Arabinofuranosylcytosine: Differential Effect on Chain Initiation and Elongation in Human Lymphoblasts

A. Fridland, 1978 .

Inhibition of deoxyribonucleic acid chain initiation: a new mode of action for 1-beta-D-arabinofuranosylcytosine in human lymphoblasts.

A. Fridland, 1977, Biochemistry.

Effect of cytosine arabinoside on replicon initiation in human lymphoblasts.

A. Fridland, 1977, Biochemical and biophysical research communications.

Studies on glycogen synthesis in pigeon liver homogenates. Incorporation of hexose into glycogen.

A. Fridland, V. Nigam, 1967, The Biochemical journal.

2'-O-nitro-1-beta-D-arabinofuranosylcytosine. A new derivative of 1-beta-D-arabinofuranosylcytosine that resists enzymatic deamination and has antileukemic activity.

A. Fridland, T. Avery, T. L. Chwang, 1983, Journal of medicinal chemistry.

Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.

A. Fridland, M. Johnson, M. Johnson, 1989, Molecular pharmacology.

Stereoselective Synthesis of Carbocyclic α-L-Homonucleosides

P. Roingeard, L. Agrofoglio, A. Fridland, 1999 .

Anomalous accumulation and decay of 2',3'-dideoxyadenosine-5'-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2',3'-dideoxyinosine.

S. Broder, R. Yarchoan, D. Cooney, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

S. Broder, J. Balzarini, D. Cooney, 1986, Biochemical pharmacology.

Antiviral Activities of 9-R-2-Phosphonomethoxypropyl Adenine (PMPA) and Bis(isopropyloxymethylcarbonyl)PMPA against Various Drug-Resistant Human Immunodeficiency Virus Strains

R. V. Srinivas, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.

Identification of purine deoxyribonucleoside kinases from human leukemia cells: substrate activation by purine and pyrimidine deoxyribonucleosides.

A. Fridland, J. Sarup, 1987, Biochemistry.

A SHORT AND STEREOSELECTIVE SYNTHESIS OF CARBOCYCLIC ALPHA-L-DIDEOXYHOMONUCLEOSIDES

L. Agrofoglio, A. Fridland, F. Girard, 1998 .

Adefovir dipivoxil. Commentaries

L. Naesens, K. Goa, E. Clercq, 1999 .

Stereoselective Synthesis of Carbocyclic α‐L‐Homonucleosides

P. Roingeard, L. Agrofoglio, A. Fridland, 1999 .

Role of Purine Nucleoside Phosphorylase in Interactions between 2′,3′-Dideoxyinosine and Allopurinol, Ganciclovir, or Tenofovir

A. Ray, A. Fridland, Loren Y Olson, 2004, Antimicrobial Agents and Chemotherapy.

Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase.

T. J. Robbins, M. Connelly, A. Fridland, 1986, Cancer research.

2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.

H. Mitsuya, S. Broder, C. Perno, 1990, Molecular pharmacology.

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes.

R. V. Srinivas, A. Fridland, M. Connely, 1997, Antiviral research.

Metabolic pathways for the activation of the antiviral agent 2',3'-dideoxyguanosine in human lymphoid cells.

D. Cooney, A. Fridland, D. Johns, 1992, Molecular Pharmacology.

Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells.

A. Fridland, J. Sarup, V. Verhoef, 1989, Biochemical pharmacology.

In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine

H. Mitsuya, J. Driscoll, R. V. Srinivas, 1997, Antimicrobial agents and chemotherapy.

Cellular Factors for Resistance against Antiretroviral Agents

M. Connelly, B. Robbins, A. Fridland, 1999, Antiviral therapy.

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

J. Schuetz, Alok Kumar, M. Connelly, 1999, Nature Medicine.

Nucleotide metabolism in Ehrlich ascites carcinoma cells.

A. Fridland, P. G. Scholefield, 1969, Biochimica et biophysica acta.

Mode of action of 9-β-d-arabinosyladenine and 1-β-d-arabinosylcytosine on DNA synthesis in human lymphoblasts

A. Fridland, D. Bell, 1980 .

Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.

A. Fridland, J. Sarup, V. Verhoef, 1981, Cancer research.

Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts.

A. Fridland, V. Verhoef, 1985, Cancer research.

Synthesis of small polynucleotide chains in human lymphoblasts pretreated with methotrexate: A possible mechanism for DNA chain growth.

A. Fridland, 1976, Advances in enzyme regulation.

A Short and Stereoselective Synthesis of Carbocyclic alpha‐L‐Dideoxyhomonucleosides.

L. Agrofoglio, A. Fridland, F. Girard, 1999 .

GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma

William A. Lee, R. Jeraj, Xiaohong Liu, 2008, Clinical Cancer Research.

Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates

D. Marshall, R. V. Srinivas, A. Fridland, 1994, Antimicrobial Agents and Chemotherapy.

Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

D. Middlemas, R. V. Srinivas, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.

Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1

S. Blanchard, J. Rodman, J. Shenep, 2000, Antimicrobial Agents and Chemotherapy.

Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells.

A. Ray, A. Fridland, Jennifer E. Vela, 2004, Biochemical pharmacology.

5-Amino-4-imidazolecarboxamide riboside potentiates the metabolism and anti-human immunodeficiency virus activity of 2',3'-dideoxyinosine.

R. V. Srinivas, A. Fridland, Y. Gong, 1993, Molecular pharmacology.

Pharmacokinetics of oral zidovudine administered during labour: a preliminary study *

L. Mofenson, J. Rodman, A. Bardeguez, 2007, HIV medicine.

Metabolism and Selectivity of Arabinonucleoside in Human Lymphoid Cells 1

A. Fridland, V. Verhoef, 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Mode of action of 9-beta-D-arabinosyladenine and 1-beta-D-arabinosylcytosine on DNA synthesis in human lymphoblasts.

A. Fridland, D. Bell, 1980, Biochimica et biophysica acta.

Effect of methotrexate on deoxyribonucleotide pools and DNA synthesis in human lymphocytic cells.

A. Fridland, 1974, Cancer research.

DNA replication in methotrexate-treated human lymphoblasts.

T. Brent, A. Fridland, 1975, European journal of biochemistry.

Adenosine phosphorylase activity in mycoplasma-free growth media for mammalian cells.

G. Germain, A. Fridland, V. Verhoef, 1983, Experimental cell research.

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.

E. De Clercq, P. Herdewijn, J. Balzarini, 1993, The Journal of biological chemistry.

Acyclic NucleotideAnaloguewith Potent Antineoplastic Activity in Dogs with Spontaneous Non ^ Hodgkin ’ s Lymphoma

William A. Lee, Xiaohong Liu, M. Desai, 2008 .

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

H. Mitsuya, S. Broder, J. Mcmahon, 1986, Biochemical pharmacology.

Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

D. Middlemas, R. V. Srinivas, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.