M. Jastrzębska-Więsek

发表

Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.

M. Kołaczkowski, M. Pawłowski, A. Gryboś, 2017, Journal of medicinal chemistry.

MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.

J. Handzlik, K. Kieć‐Kononowicz, G. Latacz, 2018, Bioorganic & medicinal chemistry letters.

The preclinical discovery and development of paliperidone for the treatment of schizophrenia

M. Jastrzębska-Więsek, A. Partyka, A. Wesołowska, 2018, Expert opinion on drug discovery.

Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.

J. Łuszczki, G. Nowak, T. Bączek, 2016, Bioorganic & medicinal chemistry.

Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.

M. Kołaczkowski, M. Pawłowski, P. Bieńkowski, 2015, European journal of medicinal chemistry.

Influence of gamma-butyrolactone derivatives with analgesic properties on the prostaglandin E_{2} level and gastric mucosa in rodents

B. Malawska, T. Librowski, J. Gdula-Argasińska, 2012 .

Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity

M. Kołaczkowski, A. Bojarski, G. Satała, 2016, Journal of enzyme inhibition and medicinal chemistry.

Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).

M. Kołaczkowski, M. Pawłowski, M. Marcinkowska, 2020, European journal of medicinal chemistry.

Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.

Andrzej J Bojarski, Magdalena Jastrzębska-Więsek, Anna Partyka, 2015, Bioorganic & medicinal chemistry.

New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT_1A, 5-HT_2A, and 5-HT_7 receptor affinity and pharmacological evaluation

M. Pawłowski, A. Bojarski, G. Satała, 2013, Pharmacological reports : PR.

Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.

J. Handzlik, K. Kieć‐Kononowicz, Rafał Kurczab, 2019, European journal of medicinal chemistry.

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo

J. Handzlik, K. Kieć‐Kononowicz, Rafał Kurczab, 2018, Molecules.

Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.

J. Handzlik, K. Kieć‐Kononowicz, Rafał Kurczab, 2018, European journal of medicinal chemistry.

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

M. Kołaczkowski, M. Pawłowski, A. Newman-Tancredi, 2020, Journal of medicinal chemistry.

Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents.

M. Jastrzębska-Więsek, Z. Urbańczyk-Lipkowska, W. Malinka, 2011, European journal of medicinal chemistry.

Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats

K. Kieć‐Kononowicz, M. Kołaczkowski, G. Latacz, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Metabolic and Cardiovascular Benefits and Risks of EMD386088—A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor

M. Kołaczkowski, J. Sniecikowska, K. Pytka, 2017, Front. Neurosci..

The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties.

M. Pawłowski, A. Bojarski, Rafał Kurczab, 2017, Bioorganic & medicinal chemistry.

Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile.

A. Bojarski, Rafał Kurczab, G. Satała, 2017, Bioorganic & medicinal chemistry.

Tail suspension test does not detect antidepressant-like properties of atypical antipsychotics

M. Kołaczkowski, P. Bieńkowski, M. Jastrzębska-Więsek, 2011, Behavioural pharmacology.

Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties.

J. Karolak-Wojciechowska, J. Handzlik, K. Kieć‐Kononowicz, 2012, Bioorganic & medicinal chemistry.

Anxiolytic-like activity of zinc in rodent tests

G. Nowak, A. Sławinska, M. Jastrzębska-Więsek, 2011, Pharmacological reports : PR.

Chronic antidepressant-like effect of EMD386088, a partial 5-HT_6 receptor agonist, in olfactory bulbectomy model may be connected with BDNF and/or CREB signalling pathway

M. Kołaczkowski, J. Gdula-Argasińska, A. Siwek, 2018, Pharmacological reports : PR.

The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia

J. Gdula-Argasińska, M. Jastrzębska-Więsek, A. Partyka, 2022, International journal of molecular sciences.

N1-Azinylsulfonyl-1H-indoles: 5-HT6 Receptor Antagonists with Procognitive and Antidepressant-Like Properties.

A. Bojarski, G. Satała, P. Popik, 2016, ACS medicinal chemistry letters.

Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.

M. Kołaczkowski, Adam Bucki, M. Głuch-Lutwin, 2022, European journal of medicinal chemistry.

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists

M. Bednarski, Joanna Knutelska, M. Głuch-Lutwin, 2020, PloS one.

Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities

M. Kołaczkowski, M. Pawłowski, M. Bajda, 2018, Chemical biology & drug design.

Central activity of new xanthone derivatives with chiral center in some pharmacological tests in mice.

G. Nowak, T. Librowski, H. Marona, 2003, Polish journal of pharmacology.

Behavioral pharmacology: potential antidepressant and anxiolytic properties.

M. Jastrzębska-Więsek, A. Wesołowska, 2011, International review of neurobiology.

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity.

M. Kołaczkowski, M. Pawłowski, A. Newman-Tancredi, 2019, Journal of medicinal chemistry.

In the search for a lead structure among series of potent and selective hydantoin 5‐HT7R agents: The drug‐likeness in vitro study

J. Handzlik, K. Kieć‐Kononowicz, A. Bojarski, 2017, Chemical biology & drug design.

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT1A and 5-HT7 Antagonists in Animal Models

M. Blachuta, A. Gałuszka, A. Waszkielewicz, 2015, PloS one.

Synthesis and Pharmacological Evaluation of Novel Tricyclic[2,1‐f]theophylline Derivatives

M. Pawłowski, A. Siwek, M. Jastrzębska-Więsek, 2013, Archiv der Pharmazie.

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity.

M. Kołaczkowski, A. Bojarski, G. Satała, 2020, European journal of medicinal chemistry.

Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.

Andrzej J. Bojarski, Magdalena Jastrzębska-Więsek, Anna Partyka, 2011, Bioorganic & medicinal chemistry.

ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety

M. Kołaczkowski, P. Bieńkowski, M. Jastrzębska-Więsek, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

The preclinical discovery and development of cariprazine for the treatment of schizophrenia

M. Kołaczkowski, M. Jastrzębska-Więsek, A. Partyka, 2018, Expert opinion on drug discovery.

Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.

M. Pawłowski, A. Bojarski, G. Satała, 2013, European journal of medicinal chemistry.

Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.

Andrzej J Bojarski, Magdalena Jastrzębska-Więsek, Anna Partyka, 2012, Bioorganic & medicinal chemistry.

The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases

J. Handzlik, G. Satała, G. Latacz, 2021, International journal of molecular sciences.

An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.

J. Handzlik, Rafał Kurczab, G. Satała, 2022, Bioorganic chemistry.

Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo.

J. Handzlik, Rafał Kurczab, G. Satała, 2020, European journal of medicinal chemistry.

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment

J. Handzlik, K. Kieć‐Kononowicz, G. Satała, 2019, International journal of molecular sciences.

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine.

Rafał Kurczab, Andrzej J Bojarski, Magdalena Jastrzębska-Więsek, 2017, European journal of medicinal chemistry.

The selective 5-HT1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat

R. Depoortère, M. Kołaczkowski, A. Newman-Tancredi, 2022, Behavioural pharmacology.

Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats

M. Kołaczkowski, J. Michaluk, I. Romańska, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests

M. Kołaczkowski, A. Siwek, M. Jastrzębska-Więsek, 2014, Neuropharmacology.

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.

T. Karcz, A. Bojarski, Rafał Kurczab, 2022, European journal of medicinal chemistry.

Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro

J. Handzlik, K. Kieć‐Kononowicz, Rafał Kurczab, 2019, Molecules.

5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801

J. Gdula-Argasińska, M. Jastrzębska-Więsek, A. Partyka, 2019, Brain Research.

Derivatives of 1,3,5-triazine, a new class of 5-ht6 receptor ligands, can reverse memory impairments in novel object recognition test in rats

J. Handzlik, K. Kieć‐Kononowicz, M. Jastrzębska-Więsek, 2018, European Neuropsychopharmacology.

The add-on of 5-HT6 antagonist, but not agonist, to haloperidol treatment improves MK-801-induced memory deficits in rats

M. Jastrzębska-Więsek, A. Partyka, A. Wesołowska, 2018, European Neuropsychopharmacology.

Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.

Rafał Kurczab, Jagna Witek, Andrzej J Bojarski, 2015, European journal of medicinal chemistry.

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

M. Kołaczkowski, H. Marona, N. Szkaradek, 2020, Journal of psychopharmacology.

Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.

T. Karcz, M. Kołaczkowski, M. Marcinkowska, 2022, European journal of medicinal chemistry.

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

M. Kołaczkowski, M. Marcinkowska, E. Wyska, 2021, Journal of medicinal chemistry.

Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats

M. Kołaczkowski, J. Michaluk, I. Romańska, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Selective 5-HT6 Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats

J. Gdula-Argasińska, M. Jastrzębska-Więsek, A. Partyka, 2023, Pharmaceuticals.

Effect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats

J. Gdula-Argasińska, M. Jastrzębska-Więsek, A. Partyka, 2021, Neuropsychiatric disease and treatment.

Novel tricyclic[2,1‐f]theophylline derivatives of LCAP with activity in mouse models of affective disorders

M. Pawłowski, M. Jastrzębska-Więsek, A. Partyka, 2014, The Journal of pharmacy and pharmacology.

Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties.

M. Kołaczkowski, A. Newman-Tancredi, J. Sniecikowska, 2018, ACS chemical neuroscience.

Selective 5-HT1A receptor agonists biased to pERK1/2 or β-arrestin activation show differential in vivo behavioral profiles

M. Kołaczkowski, A. Newman-Tancredi, J. Sniecikowska, 2018, European Neuropsychopharmacology.

Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.

A. Bojarski, Rafał Kurczab, G. Satała, 2016, European journal of medicinal chemistry.

The influence of some aminoalkanolic xanthone derivatives on central nervous and cardiovascular systems in rodents.

T. Librowski, H. Marona, M. Jastrzębska-Więsek, 2004, Bollettino chimico farmaceutico.

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile

Grzegorz Ślifirski, M. Jastrzębska-Więsek, A. Partyka, 2018, Medicinal Chemistry Research.

Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as selective 5-HT7 receptor antagonists and their psychotropic properties

Andrzej J. Bojarski, Rafał Kurczab, Magdalena Jastrzębska-Więsek, 2015 .

ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety

M. Kołaczkowski, P. Bieńkowski, M. Jastrzębska-Więsek, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats

M. Kołaczkowski, A. Siwek, M. Jastrzębska-Więsek, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats

H. Marona, K. Pytka, M. Jastrzębska-Więsek, 2022, Neurochemical Research.

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

M. Kołaczkowski, M. Marcinkowska, E. Wyska, 2021, Journal of Medicinal Chemistry.

Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats

M. Kołaczkowski, J. Michaluk, M. Jastrzębska-Więsek, 2019, Behavioural Brain Research.

Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.

J. Handzlik, Rafał Kurczab, G. Satała, 2023, European journal of medicinal chemistry.

Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.

J. Handzlik, Rafał Kurczab, G. Satała, 2023, European journal of medicinal chemistry.

Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.

M. Kołaczkowski, M. Pawłowski, P. Bieńkowski, 2015, European journal of medicinal chemistry.

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity

K. Kuder, K. Kieć‐Kononowicz, G. Latacz, 2023, International journal of molecular sciences.

Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats

M. Kołaczkowski, A. Siwek, M. Jastrzębska-Więsek, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer’s Disease

J. Handzlik, T. Karcz, G. Satała, 2024, Journal of medicinal chemistry.