P K Siegl

Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.

J J Baldwin, M. Sanguinetti, R. Freidinger, 1997, Journal of medicinal chemistry.

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

R J Lynch, T. Halgren, W. Greenlee, 1991, Journal of medicinal chemistry.

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.

R J Lynch, W J Greenlee, D G Hangauer, 1992, Journal of medicinal chemistry.

Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog.

P K Siegl, P. Siegl, H C Wenger, 1985, European journal of pharmacology.

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists.

R. Chang, V. J. Lotti, P. Chakravarty, 1991, Journal of medicinal chemistry.

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

R J Lynch, M. Holloway, J. Doyle, 1991, Journal of medicinal chemistry.