Mike Randal

Allosteric inhibition of protein tyrosine phosphatase 1B

Wang Shen, Daniel A Erlanson, Christian Wiesmann, 2004, Nature Structural &Molecular Biology.

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Jian Sun, D. M. Penny, Wanli Lu, 2009, Biochemistry.

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Michelle R Arkin, Jennifer Hyde, M. Arkin, 2004, Journal of medicinal chemistry.

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.

James P Edwards, Scott D Bembenek, Lars Karlsson, 2009, Bioorganic & medicinal chemistry letters.

Binding of small molecules to an adaptive protein–protein interface

Michelle R. Arkin, Jennifer Hyde, Robert S. McDowell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Potent small-molecule binding to a dynamic hot spot on IL-2.

M. Randal, James A Wells, Mike Randal, 2003, Journal of the American Chemical Society.

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

Jian Sun, Wanli Lu, Jian Sun, 2006, Journal of medicinal chemistry.

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2.

Michelle R Arkin, Jennifer Hyde, Andrew C Braisted, 2003, Biochemistry.

Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.

Daniel A Erlanson, R. Mcdowell, A. Waight, 2003, Journal of the American Chemical Society.