Giovanna Scapin

发表

Structural biology and drug discovery.

G. Scapin, Giovanna Scapin, 2006, Current pharmaceutical design.

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

G. Scapin, Suresh B. Singh, N. Thornberry, 2008, Bioorganic & medicinal chemistry letters.

A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

G. Scapin, J. Berger, N. Thornberry, 2017, Endocrinology, diabetes & metabolism.

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

Kathy Lyons, Ping Chen, Dennis Feng, 2014, Journal of medicinal chemistry.

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.

Claude Dufresne, Yves Leblanc, E. Asante-Appiah, 2002, Biochemistry.

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

D. Zaller, S. O'keefe, G. Scapin, 2003 .

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

Luping Liu, Cornelis E C A Hop, Dennis M Schmatz, 2003, Bioorganic & medicinal chemistry letters.

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

James C. Sacchettini, Yiming Xu, C. Grubmeyer, 1994, Cell.

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.

J. Lisnock, P. Lograsso, G. Scapin, 2003, Chemistry & biology.

Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding*

E. Asante-Appiah, B. Kennedy, G. Scapin, 2006, Journal of Biological Chemistry.

Best practices for managing large CryoEM facilities.

Scott M Stagg, Anchi Cheng, Clinton S Potter, 2017, Journal of structural biology.

4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.

Joseph L Duffy, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Molecular replacement then and now

G. Scapin, Giovanna Scapin, 2013, Acta crystallographica. Section D, Biological crystallography.

Routine Single Particle CryoEM Sample and Grid Characterization by Tomography

William J. Rice, Anchi Cheng, Bridget Carragher, 2017 .

Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis

Bridget Carragher, Clinton S. Potter, Venkata P. Dandey, 2018, Nature.

Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

D. Zaller, S. O'keefe, G. Scapin, 2003, Nature Structural Biology.

The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.

Luping Liu, S. O'keefe, G. Scapin, 2009, Acta crystallographica. Section D, Biological crystallography.