José A. Fernández

发表

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

Hiroshi Deguchi, John H. Griffin, José A Fernández, 2009, Proceedings of the National Academy of Sciences.

Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation

José A Fernández, J. Griffin, K. Höckerstedt, 2006, Critical care medicine.

Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

José A Fernández, Dong Liu, M. Chopp, 2006, Nature Medicine.

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

José A Fernández, Dong Liu, J. Griffin, 2003, Nature Medicine.

Effect of hyperhomocysteinemia on protein C activation and activity.

José A Fernández, J. Griffin, T. Bottiglieri, 2002, Blood.

Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis

José A Fernández, J. Griffin, H. Repo, 2006, Critical care.

Plasma Lipoproteins, Hemostasis and Thrombosis

José A Fernández, J. Griffin, J H Griffin, 2001, Thrombosis and Haemostasis.

Protein C pathway impairment in nonsymptomatic cigarette smokers.

José A Fernández, J. Griffin, A. Gruber, 2002, Blood cells, molecules & diseases.

Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction

José A Fernández, M. Boerma, J. Griffin, 2023, Metabolites.

The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.

José A Fernández, T. Wiltshire, M. Cooke, 2008, Blood.

Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation.

José A Fernández, J. Griffin, T. Miyata, 2015, Blood.

Activated Protein C Resistance: Molecular Mechanisms

J. Griffin, J. A. Fernandez, T. Hackeng, 1995, Thrombosis and Haemostasis.

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S.

José A Fernández, M. Sanner, J. Griffin, 2017, Blood advances.

Protein S Confers Neuronal Protection During Ischemic/Hypoxic Injury in Mice

José A Fernández, J. Griffin, B. Zlokovic, 2003, Circulation.

Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II

J. Griffin, P. D. de Groot, M. Simmelink, 2002, British journal of haematology.

Activation of protein C during reperfusion in clinical liver transplantation

José A Fernández, J. Griffin, H. Repo, 2003, Transplantation.

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.

José A Fernández, J. Griffin, B. Zlokovic, 2016, Thrombosis research.

Antibody SPC-54 provides acute in vivo blockage of the murine protein C system.

José A Fernández, J. Griffin, José A. Fernández, 2013, Blood cells, molecules & diseases.

Species-specific anticoagulant and mitogenic activities of murine protein S

José A Fernández, J. Griffin, B. Zlokovic, 2009, Haematologica.

Generation and phenotypic analysis of protein S-deficient mice.

José A Fernández, J. Griffin, R. Chrast, 2009, Blood.

A novel ELISA for mouse activated protein C in plasma.

José A Fernández, D. Dwyre, J. Griffin, 2006, Journal of immunological methods.

Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model.

José A Fernández, J. Griffin, B. Zlokovic, 2003, Blood cells, molecules & diseases.

Neutral Glycosphingolipid-dependent Inactivation of Coagulation Factor Va by Activated Protein C and Protein S*

José A Fernández, J. Griffin, H. Deguchi, 2002, The Journal of Biological Chemistry.

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

José A Fernández, J. Helterbrand, J. Griffin, 2000, Critical care medicine.

Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice.

José A Fernández, M. Cohen, J. Griffin, 2011, American journal of respiratory cell and molecular biology.

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

José A Fernández, M. Boerma, Preeti Singh, 2021, PloS one.

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.

José A Fernández, J. Griffin, B. Zlokovic, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Lee D. Hallagan, José A Fernández, R. Deane, 2009, The Journal of clinical investigation.

Thrombotic Stroke : Neuroprotective Therapy by Recombinant-Activated Protein C

José A Fernández, J. Griffin, B. Zlokovic, 2016 .

The promise of protein C.

José A Fernández, J. Griffin, B. Zlokovic, 2006, Blood cells, molecules & diseases.

Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3

José A Fernández, J. Griffin, B. Zlokovic, 2004, Neuron.

Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2012, Nature Medicine.

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

José A Fernández, O. McCarty, E. Di Cera, 2007, Blood.

Anticoagulant Responses to Thrombin Are Enhanced During Regression of Atherosclerosis in Monkeys

José A Fernández, J. Griffin, D. Heistad, 2002, Circulation.

Pharmacological targeting of the thrombomodulin – activated protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2022 .

Inhibition of thrombin generation in human plasma by phospholipid transfer protein

José A Fernández, J. Griffin, J. Albers, 2015, Thrombosis Journal.

Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.

José A Fernández, J. Contreras, J. Thompson, 2004, Diabetes.

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

José A Fernández, J. Griffin, F. Castellino, 2009, Blood.

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data.

José A Fernández, G. Siuzdak, J. Griffin, 2015, Blood.

Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis.

José A Fernández, J. Griffin, S. Coughlin, 2006 .

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo.

José A Fernández, J. Griffin, N. Key, 2003, Blood.

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

José A Fernández, J. Griffin, Xia V. Yang, 2009, Blood.

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

José A Fernández, R. Deane, J. Griffin, 2009, The European journal of neuroscience.

Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C

Nigel Mackman, Edward J. Kerschen, John H. Griffin, 2007, The Journal of experimental medicine.

Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

Berislav V. Zlokovic, John H. Griffin, José A Fernández, 2001, Circulation.

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

José A Fernández, J. Griffin, H. Simon, 2018, Blood.

Neuroprotection and vasculoprotection using genetically targeted protease-ligands

José A Fernández, J. Griffin, P. Lyden, 2019, Brain Research.

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

José A Fernández, J. Griffin, B. Zlokovic, 2011, Molecular Neurodegeneration.

Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus.

José A Fernández, J. Griffin, Y. Matsumura, 2020, Blood.

Protein S, an Antithrombotic Factor, Is Synthesized and Released by Neural Tumor Cells

José A Fernández, J. Griffin, B. Evatt, 1993, Journal of neurochemistry.

Role of protein C inhibitor and tissue factor in fertilization.

José A Fernández, José A. Fernández, M. J. Heeb, 2007, Seminars in thrombosis and hemostasis.

3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina

José A Fernández, D. Weinberger, J. Griffin, 2023, International journal of molecular sciences.

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Mikko T. Huuskonen, José A Fernández, J. Griffin, 2021, The Journal of experimental medicine.

Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction

José A Fernández, D. Weinberger, J. Griffin, 2021, Biomolecules.

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.

José A Fernández, J. Griffin, B. Zlokovic, 2018, Blood.

Key Points * R 41 Q and R 46 Q point mutations in PAR 1 in mice enabled studies of APC ’ s in vivo mechanism of action in lethal sepsis and ischemic stroke

José A Fernández, J. Griffin, B. Zlokovic, 2018 .

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.

José A Fernández, J. Griffin, José A. Fernández, 2002, Seminars in hematology.

Plasma protein S residues 37–50 mediate its binding to factor Va and inhibition of blood coagulation

José A Fernández, J. Griffin, R. Mesters, 2013, Thrombosis and Haemostasis.

Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe.

José A Fernández, J. Griffin, P. Dawson, 2002, Chemistry & biology.

Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism.

José A Fernández, J. Hansen, S. Braekkan, 2012, Thrombosis research.

Activation of protein C and hemodynamic recovery after coronary artery bypass surgery.

José A Fernández, J. Griffin, R. Lassila, 2007, The Journal of thoracic and cardiovascular surgery.

Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis

José A Fernández, D. Dwyre, J. Griffin, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

José A Fernández, J. Griffin, A. Gruber, 2006, British journal of haematology.

CSP ctivation of protein C and hemodynamic recovery after oronary artery bypass surgery

José A Fernández, J. Griffin, José A. Fernández, 2006 .

Prothrombin Residues 473–487 Contribute to Factor Va Binding in the Prothrombinase Complex*

José A Fernández, J. Griffin, R. Mesters, 2004, Journal of Biological Chemistry.

in vivo Platelet factor 4 enhances generation of activated protein C in vitro and

José A Fernández, J. Griffin, N. Key, 2013 .

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Laura D. Healy, José A Fernández, O. McCarty, 2017, The Journal of Biological Chemistry.

Serum amyloid A4 is a procoagulant apolipoprotein that it is elevated in venous thrombosis patients

José A Fernández, J. Griffin, H. Deguchi, 2019, Research and practice in thrombosis and haemostasis.

Functional recovery after embolic stroke in rodents by activated protein C

José A Fernández, M. Chopp, J. Griffin, 2005, Annals of neurology.

Brain-specific protein C activation during carotid artery occlusion in humans.

José A Fernández, R. Macko, J. Griffin, 1999, Stroke.

Activated protein C and ischemic stroke

José A Fernández, J. Griffin, B. Zlokovic, 2004, Critical care medicine.

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2

José A Fernández, O. McCarty, J. Griffin, 2008, Journal of thrombosis and haemostasis : JTH.

Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway.

José A Fernández, J. Griffin, J. A. Fernandez, 2001, Blood.

High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C.

José A Fernández, J. Griffin, L. Curtiss, 1999, The Journal of clinical investigation.

Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

José A Fernández, J. Griffin, R. Milner, 2020, Frontiers in Neuroscience.

Impairments of the protein C system and fibrinolysis in infection-associated stroke.

José A Fernández, Michael Fisher, R. Macko, 1996, Stroke.

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Lee D. Hallagan, José A Fernández, R. Deane, 2009, Journal of Clinical Investigation.

Cardiolipin is a normal component of human plasma lipoproteins.

José A Fernández, J. Griffin, T. Hackeng, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The Apolipoprotein C-I Content of Very-Low-Density Lipoproteins Is Associated with Fasting Triglycerides, Postprandial Lipemia, and Carotid Atherosclerosis

José A Fernández, J. Björkegren, J. Hansen, 2011, Journal of lipids.

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

José A Fernández, J. Griffin, Xia V. Yang, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1

José A Fernández, J. Griffin, R. Schuepbach, 2009, Thrombosis and Haemostasis.

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C

José A Fernández, Dong Liu, J. Griffin, 2004, Nature Medicine.

Cardiolipin enhances protein C pathway anticoagulant activity.

José A Fernández, J. Griffin, J. A. Fernandez, 2000, Blood cells, molecules & diseases.

Polyunsaturated Fatty Acid-Enriched Lipid Fingerprint of Glioblastoma Proliferative Regions Is Differentially Regulated According to Glioblastoma Molecular Subtype

José A Fernández, G. Barceló-Coblijn, José A. Fernández, 2022, International journal of molecular sciences.

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

José A Fernández, J. Griffin, M. Hessner, 2010, The Journal of clinical investigation.

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.

José A Fernández, J. Griffin, M. Hessner, 2015, Blood.

Activated Protein C Promotes Neovascularization and Neurogenesis in Postischemic Brain via Protease-Activated Receptor 1

José A Fernández, J. Griffin, B. Zlokovic, 2008, The Journal of Neuroscience.

Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3–Phosphatidylinositol 3-Kinase–Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region

José A Fernández, J. Griffin, B. Zlokovic, 2010, The Journal of Neuroscience.

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids.

J. Griffin, R. Brekken, W. Ruf, 2020, Blood.

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

José A Fernández, J. Griffin, B. Zlokovic, 2022, Frontiers in Neuroscience.

Species‐dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

José A Fernández, J. Griffin, B. Zlokovic, 2009, Journal of neurochemistry.

Activated protein C and inflammation in human myocardium after heart surgery

José A Fernández, J. Griffin, J. A. Fernandez, 2001, American journal of hematology.

Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice.

José A Fernández, M. Cohen, J. Griffin, 2011, American journal of respiratory cell and molecular biology.

Activated protein C

José A Fernández, J. Griffin, José A. Fernández, 2007, Journal of thrombosis and haemostasis : JTH.

Activated Protein C Reduces Graft Neutrophil Activation in Clinical Renal Transplantation

José A Fernández, K. Salmela, L. Lindgren, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Activated Protein C Ameliorates Chronic Graft-Versus-Host Disease by PAR1-dependent Biased Cell Signaling on T-cells.

José A Fernández, J. Griffin, D. Nemazee, 2019, Blood.

Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library

José A Fernández, C. Mallari, X. Xu, 2023, Blood advances.

Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C.

J. Griffin, K. Radtke, José A. Fernández, 1995, The Biochemical journal.

Potent blood coagulant activity of human semen due to prostasome-bound tissue factor.

José A Fernández, J. Griffin, K. Radtke, 1997, Biology of reproduction.

Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C

José A Fernández, J. Griffin, R. Milner, 2016, Experimental Neurology.

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data.

José A Fernández, G. Siuzdak, J. Griffin, 2015, Blood.

Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C.

José A Fernández, H. Halkin, J. Griffin, 1999, Blood.

Physiological coagulation inhibitors (protein S, protein C and antithrombin III) in severe preeclamptic states and in users of oral contraceptives.

José A Fernández, J. A. Fernandez, J. Gilabert, 1988, Thrombosis research.

Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin.

José A Fernández, J. Griffin, A. Gruber, 1992, Blood.

Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors.

José A Fernández, J. Griffin, P. D. de Groot, 2002, Blood.

Dermatan Sulfate and LMW Heparin Enhance the Anticoagulant Action of Activated Protein C

José A Fernández, J. Griffin, J. A. Fernandez, 1999, Thrombosis and Haemostasis.

Cardiopulmonary bypass and activation of antithrombotic plasma protein C.

José A Fernández, J. Griffin, J. A. Fernandez, 1999, The Journal of thoracic and cardiovascular surgery.