Jacqueline L. Blankman

发表

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

Benjamin F. Cravatt, Paul Wren, Shobha N. Bhattachar, 2011, Journal of Pharmacology and Experimental Therapeutics.

The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice

D. Boger, J. Long, B. Cravatt, 2012, British journal of pharmacology.

Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects

H. Mefford, K. Mackie, T. Bird, 2013, Human mutation.

Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators

Cheryl A. Grice, G. O'neill, I. Fraser, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain

S. Schreiber, B. Cravatt, B. Melillo, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain

Shobha N. Bhattachar, D. Nomura, B. Cravatt, 2011 .

Chemical Probes of Endocannabinoid Metabolism

B. Cravatt, Jacqueline L. Blankman, 2013, Pharmacological Reviews.

A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol

B. Cravatt, G. Simon, Jacqueline L. Blankman, 2007, Chemistry & biology.

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.

John T. Melchior, Richard G. Lee, B. Cravatt, 2013, Cell reports.

Activation of the endocannabinoid system by organophosphorus nerve agents.

J. Casida, D. Nomura, B. Cravatt, 2008, Nature chemical biology.

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.

Sherry L. Niessen, Heather S Hoover, B. Cravatt, 2008, Bioorganic & medicinal chemistry letters.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Peter T. Nguyen, D. Selley, D. Nomura, 2010, Nature Neuroscience.

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

Sherry L. Niessen, B. Cravatt, A. Adibekian, 2010, Proceedings of the National Academy of Sciences.

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

Agnes L. Bodor, K. Mackie, T. Möller, 2010, Nature Neuroscience.

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

G. Siuzdak, J. Long, B. Cravatt, 2013, Proceedings of the National Academy of Sciences.

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.

D. Selley, B. Cravatt, A. Lichtman, 2015, Cell reports.

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

D. Nomura, J. Long, B. Cravatt, 2011, Science.

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

Joseph Tam, Grzegorz Godlewski, Alexandros Makriyannis, 2010, Chemistry & biology.

Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.

Cheryl A. Grice, G. O'neill, G. Simon, 2018, Journal of medicinal chemistry.

Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice

B. Cravatt, Qing-song Liu, Peng Zhong, 2011, The Journal of Neuroscience.

ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice

Eric A. Horne, D. Selley, J. Oakley, 2014, Neuron.

Endocannabinoid Overload

B. Cravatt, A. Lichtman, Jacqueline L. Blankman, 2010, Molecular Pharmacology.

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.

B. Cravatt, Weiwei Li, J. Blankman, 2007, Journal of the American Chemical Society.

In situ identification of cellular drug targets in mammalian tissue

B. Cravatt, Carlos Guijas, Jacqueline L. Blankman, 2022, Cell.

Characterization of Lipid Hydrolases in Endocannabinoid Signaling and Neurodegeneration

Jacqueline L. Blankman, 2012 .

Genetic deletion of monoacylglycerol lipase alters endocannabinoid‐mediated retrograde synaptic depression in the cerebellum

B. Cravatt, Qing-song Liu, Peng Zhong, 2011, The Journal of physiology.