D. Heal

H. Jackson, S. Cheetham, D. Heal, 1998, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

The effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive shock

D. Heal, S. L. Smith, 1988, Neuropharmacology.

Psychedelic drug abuse potential assessment research for new drug applications and Controlled Substances Act scheduling

R. Griffiths, J. Henningfield, C. Nichols, 2022, Neuropharmacology.

Behavioural effects of central and peripheral injection of various analogues and metabolites of Thyrotropin Releasing Hormone (TRH)

M. Youdim, A. R. Green, D. Heal, 1981, Neuropharmacology.

Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine and l-dopa to rats

M. Bloomfield, D. Heal, D. Grahame-Smith, 1978, Psychopharmacology.

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

D. Heal, D. Grahame-Smith, A. Green, 1977, Psychopharmacology.

[3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: Effect of administration of various antidepressant treatments

S. Cheetham, D. Heal, J. Viggers, 1993, Neuropharmacology.

GABA-evoked depolarisations in the rat cortical wedge: involvement of GABAA receptors and HCO3 − ions

D. Heal, K. Thompson, I. Phillips, 1998, Brain Research.

Repeated electroconvulsive shock attenuates clonidine-induced hypoactivity in rodents.

D. Heal, H. Akagi, J. Bowdler, 1981, European journal of pharmacology.

Chapter 23 Antidepressant and anxiolytic drugs

S. Cheetham, D. Heal, 2000 .

The effects of acute and chronic lithium treatment on pilocarpine‐stimulated phosphoinositide hydrolysis in mouse brain in vivo

D. Kendall, D. Heal, P. Whitworth, 1990, British journal of pharmacology.

Catecholamines: Knowledge and understanding in the 1960s, now, and in the future

S. Stanford, D. Heal, David J. Heal, 2019, Brain and neuroscience advances.

The contrasting actions of TRH and cycloheximide in altering the effects of centrally acting drugs: Evidence for the non-involvement of dopamine sensitive adenylate cyclase

P. Kelly, D. Heal, D. Grahame-Smith, 1976, Neuropharmacology.

Novel targets for the treatment of obesity: a review of progress

Keith Dickinson, David J. Heal, H. Jackson, 2004 .

Administration of thyrotropin releasing hormone (TRH) to rats releases dopamine in n. accumbens but not n. caudatus

D. Heal, A. Green, 1979, Neuropharmacology.

8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation.

D. Heal, K. Martin, M. Prow, 1996, European journal of pharmacology.

TRH‐Catecholamine Interactions in Brain and Spinal Cord a

C. Marsden, K. Fone, D. Heal, 1989, Annals of the New York Academy of Sciences.

Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues

C. Marsden, D. Heal, M. Youdim, 1987, Neuropharmacology.

Studies on the locomotor activity produced by injection of dibutyryl cyclic 3 5 AMP into the nucleus accumbens of rats

A. Phillips, D. Heal, A. Green, 1978, Neuropharmacology.

Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat cortical membranes

D. Heal, I. Phillips, K. Martin, 1989, Journal of psychopharmacology.

Iodoform toxicity following the use of B.I.P.P.: A potential hazard

A. Freeland, D. Heal, A. O'connor, 1977, The Journal of Laryngology & Otology.

Inhibition of adenyl cyclase by an exotoxin of Bacillus thuringiensis

D. Heal, D. Grahame-Smith, P. Isaac, 1975, Nature.

CNS stimulants

J. Henningfield, D. Heal, Sharon L. Smith, 2014, Neuropharmacology.

Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding

S. Wonnacott, V. L. Wright, Polymnia Georgiou, 2018, Addiction biology.

The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D2 receptor occupancy and stimulus generalization to a d-amphetamine cue

P. Hutson, D. Heal, Patrick L. Love, 2016, Neuropharmacology.

Repeated electroconvulsive shock increases the behavioural responses of rats to injection of both dopamine and dibutyryl cyclic amp into the nucleus accumbens

D. Heal, A. Green, 1978, Neuropharmacology.

Antidepressant treatments: effects in rodents on dose‐response curves of 5‐hydroxytryptamine‐ and dopamine‐mediated behaviours and 5‐HT2 receptor number in frontal cortex

V. Nimgaonkar, D. Heal, A. Green, 1983, British journal of pharmacology.

Regulatory Framework and Guidance to the Evaluation of the Abuse Liability of Drugs in the United States and Europe

A. Giarola, D. Heal, S. Calderon, 2015 .

Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: Update on recommendations from the British Association for Psychopharmacology

D. Nutt, U. Müller, E. Sonuga-Barke, 2014, Journal of psychopharmacology.

Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats – possible relevance in the psychopathology and treatment of binge-eating disorder

F. Tarazi, J. Gosden, S. Cheetham, 2017, Journal of psychopharmacology.

ADHD: current and future therapeutics.

R. Findling, D. Heal, Sharon L. Smith, 2012, Current topics in behavioral neurosciences.

Determination of body composition in conscious adult female Wistar utilising total body electrical conductivity

K. Dickinson, G. Telford, D. Heal, 2001, Physiology & Behavior.

The influence of central noradrenergic function on 5-HT2-mediated head-twitch responses in mice: Possible implications for the actions of antidepressant drugs

D. Heal, C. L. Davies, J. Philpot, 2006, Psychopharmacology.

A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to d -amfetamine, methylphenidate and modafinil

J. Gosden, D. Heal, C. France, 2013, Neuropharmacology.

The influence of l-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on α2- and β-adrenoceptor function in the brain of the rat: Implications for the potentiation of antidepressant therapy by T3

L. Bristow, D. Heal, J. Bloomfield, 1987, Neuropharmacology.

Release of dopamine in the nucleus accumbens of rats by thyrotropin releasing hormone (TRH) [proceedings].

D. Heal, A. Green, 1978, British journal of pharmacology.

Experimental strategies to discover and develop the next generation of psychedelics and entactogens as medicines

D. Heal, J. Gosden, C. Atterwill, 2022, Neuropharmacology.

A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice

D. Heal, J. Philpot, 2004, Psychopharmacology.

The β 2-adrenoceptor agonists clenbuterol and salbutamol enhance the hypothermic action of 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) in mice by a central mechanism

G. Goodwin, D. Heal, R. D. Souza, 1986, Neuropharmacology.

Intracerebroventricular administration of 5,7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors

D. Heal, D. J. Heal, J. Philpot, 1985, Neuropharmacology.

The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety

S. Cheetham, D. Heal, Sharon L. Smith, 2009, Neuropharmacology.

Metabolic consequences of antipsychotic therapy: preclinical and clinical perspectives on diabetes, diabetic ketoacidosis, and obesity.

J. Gosden, H. Jackson, S. Cheetham, 2012, Handbook of experimental pharmacology.

Experimental Approaches to Anxiety and Depression

D. Heal, J. Elliott, C. A. Mardens, 1993 .

A short history of amphetamine

D. Nutt, J. Gosden, D. Heal, 2013 .

Pharmacological characterisation of the thermogenic effect of bupropion.

M. Stock, D. Heal, I. Connoley, 2004, European journal of pharmacology.

A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine

J. Gosden, D. Heal, G. Luscombe, 2005, Psychopharmacology.

Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement

S. Wonnacott, D. Heal, Sharon L. Smith, 2021, Journal of psychopharmacology.

Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders.

J. Gosden, D. Heal, Sharon L. Smith, 2009, British journal of clinical pharmacology.

What pharmacological interventions are effective in binge-eating disorder? Insights from a critical evaluation of the evidence from clinical trials

J. Gosden, D. Heal, 2022, International Journal of Obesity.

What is the prognosis for new centrally-acting anti-obesity drugs?

J. Gosden, D. Heal, Sharon L. Smith, 2012, Neuropharmacology.

New Drugs to Treat ADHD: Opportunities and Challenges in Research and Development.

D. Heal, S. L. Smith, J. Gosden, 2022, Current topics in behavioral neurosciences.

The 5-HT6 receptor as a target for developing novel antiobesity drugs.

J. Gosden, D. Heal, Sharon L. Smith, 2011, International review of neurobiology.

Effects of lisdexamfetamine in a rat model of binge-eating

F. Murray, P. Hutson, D. Heal, 2015, Journal of psychopharmacology.

Effect of chronic treatment with 5‐HT1 agonist (8‐OH‐DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5‐HT1 and 5‐HT2 agonists

G. Goodwin, D. Heal, R. Souza, 1986, British journal of pharmacology.

The effects of the peptide-coupling agent, EEDQ, on 5-HT2A receptor binding and function in rat frontal cortex

S. Cheetham, D. Heal, K. Martin, 1999, Neuropharmacology.

KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders.

D. Heal, Sharon L. Smith, K. Martin, 2006, CNS drug reviews.

Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat

H. Jackson, D. Heal, L. Hutchins, 1997, British journal of pharmacology.

Lisdexamfetamine and immediate release d-amfetamine – Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity

J. Gosden, D. Heal, H. Rowley, 2012, Neuropharmacology.

A review of late-stage CNS drug candidates for the treatment of obesity

J. Gosden, D. Heal, Sharon L. Smith, 2013, International Journal of Obesity.

The Anxiogenic Agents, Yohimbine and FG 7142, Disrupt the Noradrenergic Response to Novelty

S. C. Stanford, S. Stanford, D. Heal, 1998, Pharmacology Biochemistry and Behavior.

Thermogenic effects of sibutramine and its metabolites

M. Stock, D. Heal, M. Stock, 1999, British journal of pharmacology.

Receptor binding and functional evidence suggest that postsynaptic α2-adrenoceptors in rat brain are of the α2D subtype

J. Gosden, S. Cheetham, D. Heal, 1995 .

Investigation of the mechanisms underlying the hypophagic effects of the 5‐HT and noradrenaline reuptake inhibitor, sibutramine, in the rat

H. Jackson, D. Heal, L. Hutchins, 1997, British journal of pharmacology.

The Pharmacology of noradrenaline in the central nervous system

C. Marsden, D. Heal, 1990 .

IS VEHICLE‐INJECTION AN ADEQUATE CONTROL FOR EVALUATING DRUG EFFECTS?

Sc Stanford, S Davis, David J. Heal, 1992 .

8-OH-DPAT-Induced Hypothermia in Rodents. A Specific Model of 5-HTlA Autoreceptor Function?

D. Heal, K. Martin, 1991 .

Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex.

D. Heal, S. Butler, E. Hurst, 1989, Journal of neurochemistry.

Sibutramine does not decrease the number of 5-HT re-uptake sites in rat brain and, like fluoxetine, protects against the deficits produced by dexfenfluramine

S. Cheetham, D. Heal, J. Viggers, 2000, Neuropharmacology.

Mediation of mydriasis in conscious rats by central postsynaptic α 2-adrenoceptors

D. Heal, S. Butler, M. Prow, 1995, Pharmacology Biochemistry and Behavior.

Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats

J. Gosden, D. Heal, H. Rowley, 2014, Journal of psychopharmacology.

In mice repeated administration of electroconvulsive shock or desmethylimipramine produces rapid alterations in 5-HT2-mediated head-twitch responses and cortical 5-HT2 receptor number.

D. Heal, A. Metz, 1986, European journal of pharmacology.

Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine

P. Hutson, D. Heal, S. Vickers, 2017, Journal of psychopharmacology.

Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic α2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride

D. Heal, M. Prow, W. Buckett, 2005, Psychopharmacology.

Quantification of presynaptic α2-adrenoceptors in rat brain after short-term DSP-4 lesioning

D. Heal, S. Butler, M. Prow, 1993 .

D1 receptor binding in rat striatum: modification by various D1 and D2 antagonists, but not by sibutramine hydrochloride, antidepressants or treatments which enhance central dopaminergic function

S. Cheetham, D. Heal, K. Martin, 2005, Journal of Neural Transmission / General Section JNT.

The effects of acute and repeated administration of various antidepressant drugs on clonidine-induced hypoactivity in mice and rats

S. Lister, D. Heal, S. L. Smith, 1983, Neuropharmacology.

Hypothermia induced by baclofen, a possible index of GABAB receptor function in mice, is enhanced by antidepressant drugs and ECS

G. M. Goodwin, D. Heal, J. Gray, 1987, British journal of pharmacology.

The NK1R-/- mouse phenotype suggests that small body size, with a sex- and diet-dependent excess in body mass and fat, are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder

S. Stanford, D. Heal, K. Pillidge, 2016, Journal of psychopharmacology.

The NK 1 R-/-mouse phenotype suggests that small body size , with a sex-and diet-dependent excess in body mass and fat , are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder

S. Stanford, D. Heal, K. Pillidge, 2016 .

The behavioural response of mice lacking NK1 receptors to guanfacine resembles its clinical profile in treatment of ADHD

S. Stanford, D. Heal, S. Stanford, 2014, British journal of pharmacology.

Dopamine D2 receptors: A potential pharmacological target for nomifensine and tranylcypromine but not other antidepressant treatments

S. Cheetham, D. Heal, I. Phillips, 1995, Pharmacology Biochemistry and Behavior.

5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354

S. Stanford, S. Géranton, D. Heal, 2004, Neuropharmacology.

Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge

D. Heal, Elizabeth S. Ash, S. Clare Stanford, 2014, Neuropharmacology.

Central serotonin receptors and psychotropic drugs

C. Marsden, D. Heal, 1992 .

NEUROPHARMACOLOGY

J. Henningfield, D. Heal, S. L. Smith, 1996 .

Characterization of 8‐OH‐DPAT‐induced hypothermia in mice as a 5‐HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants

D. Heal, I. Phillips, K. Martin, 1992, British journal of pharmacology.

Common profile of D1 receptor antagonists and atypical antipstchotic drugs revealed by analysis of dopamine turnover

C. Czudek, D. Heal, W. Buckett, 1994, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Subjective and reinforcing effects of modafinil in rats

J. Gosden, D. Heal, D. Hackett, 2014 .

Psychedelic drug abuse potential assessment for new drug applications and controlled substance scheduling: A United States perspective

J. Henningfield, D. Heal, Sharon L. Smith, 2023, Journal of psychopharmacology.

Opposing roles for 5‐HT1B and 5‐HT3 receptors in the control of 5‐HT release in rat hippocampus in vivo

K F Martin, D. Heal, I. Phillips, 1992, British journal of pharmacology.

Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.

S. Bunn, D. Heal, S. L. Smith, 1984, Journal of neural transmission.

Obesity: a global pandemic.

J. Seidell, N. Finer, J. Antel, 2005 .

Psychedelics – Re-opening the doors of perception

D. Nutt, B. Frenguelli, J. Henningfield, 2018, Neuropharmacology.

Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

D. Heal, W. R. Buckett, S. Butler, 1989 .

Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: Update on recommendations from the British Association for Psychopharmacology

D. Nutt, U. Müller, E. Sonuga-Barke, 2014, Journal of psychopharmacology.

Studies on rat brain catecholamine synthesis and Β-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol

V. Nimgaonkar, D. Heal, C. L. Davies, 2005, Journal of Neural Transmission.

Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding

S. Wonnacott, V. L. Wright, Polymnia Georgiou, 2018, Addiction biology.

The behavioural response of mice lacking NK1 receptors to guanfacine resembles its clinical profile in treatment of ADHD

S. Stanford, D. Heal, Y. Tsai, 2014, British journal of pharmacology.

A microdialysis and behavioural investigation of modafinil in freely moving rats

D. Heal, H. Rowley, D. Hackett, 2014 .

A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to d -amfetamine, methylphenidate and modafinil

J. Gosden, D. Heal, C. France, 2013, Neuropharmacology.

Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels.

D. Reiche, S. Shyng, C. Lynch, 2012, American journal of physiology. Endocrinology and metabolism.

The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

G. Goodwin, D. Heal, A. Green, 2004, Psychopharmacology.