H. Kleinert

发表

Blood pressure during normal daily activities, sleep, and exercise. Comparison of values in normal and hypertensive subjects.

J. Laragh, T. Pickering, G. Harshfield, 1982, JAMA.

Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress.

J S Borer, D. Pregibon, L. Denby, 1983, Circulation.

Chapter 7 Antihypertensive Agents

J. Plattner, H. Kleinert, 1987 .

Atrial natriuretic factor: structure and functional properties.

J. Laragh, S. Atlas, H. Kleinert, 1985, Kidney international.

Discovery of a well-absorbed, efficacious renin inhibitor, A-74273.

P. Kovar, H. Kleinert, J. Polakowski, 1992, Hypertension.

Cardiovascular Effects and Hemodynamic Mechanism of Action of the Novel, Nonpeptidic Renin Inhibitor A‐74273 in Dogs

P. Kovar, H. Kleinert, J. Wessale, 1993, Journal of cardiovascular pharmacology.

Renin inhibitors: discovery and development. An overview and perspective.

H. Kleinert, 1989, American journal of hypertension.

Effects of renin inhibitor A-72517 on hemodynamics and cardiac function in sodium-depleted dogs.

P. Kovar, S. Rosenberg, H. Kleinert, 1993, American journal of hypertension.

Hemodynamic and Humoral Effects of the New Renin Inhibitor Enalkiren in Normal Humans

A. Delabays, H. Glassman, R. Luther, 1989, Hypertension.

Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects.

J. Ménard, H. Glassman, D. Moyse, 1995, Circulation.

Situational Variations of Blood Pressure in Ambulatory Hypertensive Patients

J. Laragh, T. Pickering, G. Harshfield, 1982, Psychosomatic medicine.

Effects of chronic infusion of renin inhibitor A-64662 in sodium-depleted monkeys.

H. Kleinert, K. Verburg, B. Wílkes, 1989, Hypertension.

Comparable effect of isotonic infusions on blood pressure in the anephric rat.

J. Laragh, E. Vaughan, J. Sealey, 1983, Hypertension.

Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs.

J. Laragh, E. Vaughan, S. Atlas, 1984, The American journal of medicine.

Effects of the Renin Inhibitor A‐64662 in Monkeys and Rats with Varying Baseline Plasma Renin Activity

R. Luther, J. Plattner, H. Kleinert, 1988, Hypertension.

Ambulatory monitoring in the evaluation of blood pressure in patients with borderline hypertension and the role of the defense reflex.

J. Laragh, T. Pickering, G. Harshfield, 1982, Clinical and experimental hypertension. Part A, Theory and practice.

Prolonged Duration of Blood Pressure Response to Enalkiren, the Novel Dipeptide Renin Inhibitor, in Essential Hypertension

H. Glassman, R. Luther, J. Cavanaugh, 1990, Hypertension.

Cardiovascular effects of atrial natriuretic factor in anesthetized and conscious dogs.

J. Laragh, M. Volpe, S. Atlas, 1986, Hypertension.

Modified peptides which display potent and specific inhibition of human renin.

P. Marcotte, J. Plattner, H. Kleinert, 1987, Biochemical and biophysical research communications.

Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide

J. Laragh, J. Lewicki, A. Januszewicz, 1984, Nature.

Ca-dependent hemodynamic and natriuretic effects of atrial extract in isolated rat kidney.

J. Laragh, J. Sealey, S. Atlas, 1984, The American journal of physiology.

Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist.

D. Albert, J. Summers, G. Carter, 1996, Advances in experimental medicine and biology.

Ex vivo inhibition of β-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist

D. Albert, J. Summers, G. Carter, 1997, Inflammation Research.

Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.

J. Laragh, A. Januszewicz, J. Sealey, 1984, Hypertension.

Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion.

P. Teirstein, C. Grines, A. Lansky, 1999, The American journal of cardiology.

Renal and cardiovascular effects of atrial natriuretic factor.

H. Kleinert, T. Maack, 1986, Biochemical pharmacology.

Renin inhibition

H. Kleinert, 2004, Cardiovascular Drugs and Therapy.

Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging

C. Sotak, M. Fisher, R. Carano, 1998, Neurology.

Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension.

J. Laragh, J. Lewicki, E. Vaughan, 1984, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Cardiovascular actions of the primate-selective renin inhibitor, A-62198.

S. Rosenberg, J. Plattner, H. Kleinert, 1988, The Journal of pharmacology and experimental therapeutics.

Pheochromocytoma and prazosin.

J. Laragh, T. Pickering, L. Resnick, 1983, Annals of internal medicine.

Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.

R. Maki, J. Plattner, H. Kleinert, 1987, Journal of medicinal chemistry.

Discovery of a peptide-based renin inhibitor with oral bioavailability and efficacy.

P. Kovar, S. Rosenberg, H. Kleinert, 1992, Science.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency.

D. Egan, P. Marcotte, H. Kleinert, 1988, Journal of medicinal chemistry.

Design of a well-absorbed renin inhibitor.

D. Egan, S. Rosenberg, H. Kleinert, 1991, Journal of medicinal chemistry.

Intraocular pressure lowering effects of the renin inhibitor ABBOTT-64662 diacetate in animals.

H. Kleinert, C. Wismer, W. J. Giardina, 1990, Journal of ocular pharmacology.

Renin inhibitors: C-terminal oxetanes as potent transition-state mimics.

S. Rosenberg, H. Kleinert, W. Baker, 1994, Bioorganic & medicinal chemistry.

Slow, tight binding to human renin of some nonpeptidic renin inhibitors containing a 4‐methoxymethoxypiperidinylamide at the P4 position

S. Rosenberg, B. Dayton, H. Kleinert, 1992, FEBS letters.

Effect of Atrial Natriuretic Factor on Blood Pressure, Renin, and Aldosterone in Goldblatt Hypertension

J. Laragh, E. Vaughan, M. Volpe, 1985, Hypertension.

ORALLY BIOAVAILABLE PEPTIDELIKE MOLECULES : A CASE HISTORY

H. Kleinert, W. Baker, H. Stein, 1993 .

Peptide analogues of angiotensinogen. Effect of peptide chain length on renin inhibition.

J. Greer, H. Sham, J. Plattner, 1986, Biochemical and biophysical research communications.

What is the value of home blood pressure measurement in patients with mild hypertension?

J. Laragh, R. Devereux, T. Pickering, 1984, Hypertension.

Atrial natriuretic factor (auriculin): structure and biological effects.

J. Laragh, J. Lewicki, M. Volpe, 1985, Journal of clinical hypertension.

Effects of carbon monoxide or low oxygen gas mixture inhalation on regional oxygenation, blood flow, and small vessel blood content of the rabbit heart

H. Weiss, H. Kleinert, J. Scales, 2004, Pflügers Archiv.

Cardiovascular effects of synthetic atrial natriuretic factor (ANF) in normal dogs

M. Volpe, H. Kleinert, M. Camargo, 1985 .

Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.

J. Greer, P. Marcotte, G. Bolis, 1987, Journal of medicinal chemistry.

Profile of the Renin Inhibitor, Enalkiren (ABBOTT‐64662)

R. Luther, M. Karol, J. Plattner, 1990 .

Effect of intrarenal renin inhibition on renal hemodynamics and excretory function.

S. Rosenberg, H. Kleinert, K. Verburg, 1990, The American journal of physiology.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.

J. Greer, H. Sham, P. Marcotte, 1988, Journal of Medicinal Chemistry.

Renin inhibitors Improvements in the stability and biological activity of small peptides containing novel Leu‐Val replacements

P. Marcotte, J. Plattner, H. Kleinert, 1988, FEBS Letters.

Renin inhibitors based on novel dipeptide analogs: Increased efficacy through systematic inclusion of polar functionality

D. Kempf, J. Plattner, H. Kleinert, 1988 .

Conformationally restricted peptide isosteres. 2.1 Synthesis and in vitro potency of dipeptide renin inhibitors employing a 2-alkylsulfonyl-3-phenylcyclopropane carboxamide as a P3 amino acid replacement ☆

Stephen R. Martin, H. Kleinert, W. Baker, 1992 .

Design of rigid heterocyclic phenylalanine replacements for incorporation into renin inhibitors

D. Kempf, J. Plattner, H. Kleinert, 1990 .

Renal hemodynamic and excretory responses to renin inhibition induced by A-64662.

H. Kleinert, K. Verburg, G. Young, 1990, The Journal of pharmacology and experimental therapeutics.