O. Quintana-Bustamante

发表

Targeted gene therapy and cell reprogramming in Fanconi anemia

Luigi Naldini, Elena Almarza, Angelo Lombardo, 2014, EMBO molecular medicine.

In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.

J. Segovia, J. Bueren, A. Díez, 2007, Human gene therapy.

Functional analysis of gammaretroviral vector transduction by quantitative PCR

A. Díez, J. Bautista, O. Quintana-Bustamante, 2006, The journal of gene medicine.

Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis

T. Lister, J. Fitzgibbon, D. Bonnet, 2012, Leukemia.

Gene Therapy for Erythroid Metabolic Inherited Diseases

S. Navarro, J. Segovia, M. García-Gómez, 2013 .

Bone Marrow-Derived Cells Promote Liver Regeneration in Mice With Erythropoietic Protoporphyria

E. Salido, J. Segovia, J. Bueren, 2009, Transplantation.

Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA

P. Duchateau, L. Poirot, J. Segovia, 2019, PloS one.

Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα

M. Fraga, T. Graf, J. Segovia, 2016, Leukemia.

Advances in the gene therapy of monogenic blood cell diseases

J. Segovia, J. Bueren, P. Río, 2019, Clinical genetics.

Chapter 5 Gene Editing in Adult Hematopoietic Stem Cells

J. Segovia, O. Quintana-Bustamante, S. Navarro, 2018 .

Gene Editing in Adult Hematopoietic Stem Cells

J. Segovia, O. Quintana-Bustamante, S. Navarro, 2016 .

Clinically Relevant Gene Editing in Hematopoietic Stem Cells for the Treatment of Pyruvate Kinase Deficiency Hemolytic Anemia

R. Turk, M. Behlke, M. Porteus, 2021, bioRxiv.

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10

R. Yañez, J. Segovia, J. Bueren, 2021, Stem cell research & therapy.

Gene Editing for Inherited Red Blood Cell Diseases

J. Segovia, O. Quintana-Bustamante, Isabel Ojeda-Pérez, 2022, Frontiers in Physiology.

Generation of iPSCs from Genetically Corrected Brca2 Hypomorphic Cells: Implications in Cell Reprogramming and Stem Cell Therapy

Á. Raya, J. Segovia, J. Bueren, 2014, Stem cells.

Generation of Patient-Specific induced Pluripotent Stem Cell from Peripheral Blood Mononuclear Cells by Sendai Reprogramming Vectors.

J. Segovia, O. Quintana-Bustamante, 2016, Methods in molecular biology.

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

R. Schwabe, D. Brenner, J. Segovia, 2006, Journal of hepatology.

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

F. Prósper, C. Kung, Shengfang Jin, 2015, Stem cell reports.

Cell Fusion Reprogramming Leads to a Specific Hepatic Expression Pattern during Mouse Bone Marrow Derived Hepatocyte Formation In Vivo

J. Segovia, I. Fabregat, E. Grueso, 2012, PloS one.

Clustered regularly interspaced short palindromic repeats/Cas9-mediated gene editing. A promising strategy in hematological disorders.

P. Río, O. Quintana-Bustamante, R. Torres, 2023, Cytotherapy.

New frontier in regenerative medicine: site-specific gene correction in patient-specific induced pluripotent stem cells.

J. Segovia, B. Davis, O. Quintana-Bustamante, 2013, Human gene therapy.

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

J. Mora, S. Rodríguez-Perales, J. Segovia, 2020, Nature Communications.

Long‐term skin regeneration in xenografts from iPSC teratoma‐derived human keratinocytes

M. del Río, F. Larcher, Marta García, 2016, Experimental dermatology.

Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme.

J. Segovia, J. Bueren, J. Bautista, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy

R. Yañez, A. Zapata, J. Segovia, 2021, Frontiers in Cell and Developmental Biology.

Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment

J. Segovia, J. Bueren, M. Rothe, 2021, Molecular therapy. Methods & clinical development.

Clinically relevant gene editing in hematopoietic stem cells for the treatment of pyruvate kinase deficiency

R. Turk, M. Behlke, M. Porteus, 2021, Molecular therapy. Methods & clinical development.

Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells

J. Segovia, J. Bueren, O. Quintana-Bustamante, 2020, Gene Therapy.

Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1.

J. Surrallés, S. Puerto, J. Segovia, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells

J. Segovia, J. Bueren, O. Quintana-Bustamante, 2020, Gene Therapy.

Hematopoietic mobilization in mice increases the presence of bone marrow–derived hepatocytes via in vivo cell fusion

J. Segovia, J. Bueren, I. Fabregat, 2006, Hepatology.

Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III

C. Tornador, J. Segovia, Mayka Sánchez, 2022, Haematologica.

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

R. Yañez, A. Zapata, D. Alfaro, 2020, Haematologica.

Specific correction of pyruvate kinase deficiency-causing point mutations by CRISPR/Cas9 and single-stranded oligodeoxynucleotides

J. Segovia, J. Bueren, M. Moreno-Pelayo, 2023, Frontiers in Genome Editing.