L. Müller

发表

Further investigations on the clastogenicity of paracetamol and acetylsalicylic acid in vitro.

P. Kasper, L. Müller, S. Madle, 1991, Mutation research.

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles.

Lutz Müller, David Kirkland, M. Aardema, 2006, Mutation research.

Clinical trial considerations on male contraception and collection of pregnancy information from female partners

T. Singer, C. Wandel, P. Barrow, 2012, Journal of Translational Medicine.

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

J. T. Macgregor, D. Eastmond, P. White, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

The rise and fall of photomutagenesis.

L. Müller, E. Gocke, 2013, Mutation research.

Considerations on photochemical genotoxicity: Report of the International Workshop on Genotoxicity Test Procedures Working Group

R. Snyder, N. Tanaka, C. Chignell, 2000, Environmental and molecular mutagenesis.

Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing.

P. Kasper, B. Kersten, L. Müller, 1997, Mutation research.

Species differences in the time-dependent induction of unscheduled DNA synthesis in primary hepatocytes.

K. Müller, P. Kasper, L. Müller, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

T. Singer, A. Flohr, L. Ozmen, 2012, International journal of Alzheimer's disease.

An ex vivo potency assay to assess active drug levels of a GLP-1 agonistic peptide during preclinical safety studies.

A. Papadimitriou, M. Schäfer, K. Heinig, 2015, Bioanalysis.

Genotoxic Impurities in Pharmaceuticals

Lutz Müller, Peter Kasper, P. Kasper, 2015 .

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Akifumi Shioda, Y. Sakamoto, H. Buergin, 2013, Birth defects research. Part B, Developmental and reproductive toxicology.

Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

T. Lavé, H. Grimm, L. Müller, 2009, Toxicology letters.

The Second ECVAM Workshop on Phototoxicity Testing

D. Averbeck, N. Gibbs, H. Spielmann, 2000, Alternatives to laboratory animals : ATLA.

Preclinical Safety Testing

L. Müller, E. Husar, 2013 .

The Use of Intact Mammalian Cells as Metabolic Activation Systems in Mutagenicity Tests

K. Müller, P. Kasper, L. Müller, 1990 .

The effects of interleukin-6 signal blockade on fertility, embryo-fetal development, and immunization in vivo.

T. Singer, Kana Ishihara, Y. Sakamoto, 2012, Birth defects research. Part B, Developmental and reproductive toxicology.

MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU.

L. Müller, E. Gocke, J. Whitwell, 2009, Toxicology letters.

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.

Lutz Müller, David M. De Antonis, Betsy Fritschel, 2006, Regulatory toxicology and pharmacology : RTP.

The clastogenic potential in vitro of pyrrolizidine alkaloids employing hepatocyte metabolism.

P. Kasper, L. Müller, G. Kaufmann, 1992, Mutation research.

Photochemical genotoxicity: principles and test methods. Report of a GUM task force.

Lutz Müller, Bernd Epe, Andreas Czich, 2004, Mutation research.

The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.

P. Kasper, B. Kersten, S. Brendler-Schwaab, 1999, Mutation research.

Photochemical genotoxicity and photochemical carcinogenesis--two sides of a coin?

P. Kasper, B. Kersten, L. Müller, 1998, Toxicology letters.

Genotoxicity testing of biotechnology-derived products. Report of a GUM task force. Gesellschaft für Umweltmutationsforschung.

W Suter, F E Würgler, S Albertini, 1999, Mutation research.

Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view.

L Müller, L. Müller, K Bergman, 1996, Mutation research.

Erratum to: Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

T. Singer, C. Wandel, P. Barrow, 2016, Clinical and Translational Medicine.

Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

T. Singer, C. Wandel, P. Barrow, 2016, Clinical and Translational Medicine.

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity.

Lutz Müller, Leigh Henderson, David Kirkland, 2005, Mutation research.

OTC pharmaceuticals and genotoxicity testing: the paracetamol, anthraquinone, and griseofulvin cases.

P. Kasper, L. Müller, 1995, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

The genotoxic potential in vitro and in vivo of the allyl benzene etheric oils estragole, basil oil and trans-anethole.

P. Kasper, L Müller, P Kasper, 1994, Mutation research.

Report of a comparative study of DNA damage and repair assays in primary rat hepatocytes with five coded chemicals.

W. von der Hude, P. Schmezer, L. Müller, 1991, Mutation research.

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

Lutz Müller, Thomas Pfister, Thierry Lavé, 2009, Toxicology letters.

Strategies and testing methods for identifying mutagenic risks.

J. T. Macgregor, D. Casciano, J T MacGregor, 2000, Mutation research.

Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate.

T. Pfister, H. Buergin, L. Müller, 2009, Toxicology letters.

L. Müller, 1988, Teratogenesis, carcinogenesis, and mutagenesis.

EMS in Viracept--initial ('traditional') assessment of risk to patients based on linear dose response relations.

T. Pfister, L. Müller, E. Gocke, 2009, Toxicology letters.

Strategies in case of positive in vivo results in genotoxicity testing.

Lutz Müller, Véronique Thybaud, Takehiko Nohmi, 2011, Mutation research.

Genetic Toxicology Testing Guidelines and Regulations

Lutz Müller, Hans-Jörg Martus, L. Müller, 2010 .

Micronucleus induction in mouse and rat fetuses treated transplacentally during histogenesis with mitomycin C and 7,12-dimethylbenz(a)anthracene.

L. Müller, 1988, Teratogenesis, carcinogenesis, and mutagenesis.

An assessment of the in vitro hepatocyte micronucleus assay.

K. Müller, P. Kasper, L. Müller, 1993, Mutation research.

Evaluation studies on the in vitro rat hepatocyte micronucleus assay.

P. Kasper, L. Müller, K. Müller-Tegethoff, 1995, Mutation research.

Lack of AFB(1)-induced mutagenicity in the in vitro hepatocyte micronucleus assay: Investigation of possible mechanisms.

K. Müller, P. Kasper, L. Müller, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical In Vitro and In Vivo Models

A. Greiter-Wilke, L. Müller, E. Niesor, 2015 .

Use of the photo-micronucleus assay in Chinese hamster V79 cells to study photochemical genotoxicity.

P. Kasper, B. Kersten, S. Brendler-Schwaab, 2002, Mutation research.

Development of the Threshold of Toxicological Concern Concept and its Relationship to Duration of Exposure

Lutz Müller, Alessandro Brigo, A. Brigo, 2011 .

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).

J. T. Macgregor, D. Eastmond, P. White, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Effects of visible light absorbing chemicals in the photomicronucleus test in Chinese hamster V79 cells

P. Kasper, B. Kersten, L. Müller, 2001 .

The quality of genotoxicity testing of drugs. Experiences of a regulatory agency with new and old compounds.

P. Kasper, L Müller, P Kasper, 1991, Mutagenesis.

Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds.

D. Kirkland, L Müller, L. Müller, 2000, Mutation research.

Mutagenicity testing of doxylamine succinate, an antinauseant drug.

L. Müller, S. Madle, A. Korte, 1989, Toxicology letters.

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.

Lutz Müller, Elmar Gocke, L. Müller, 2009, Mutation research.

EMS in Viracept--the course of events in 2007 and 2008 from the non-clinical safety point of view.

T. Singer, L. Müller, 2009, Toxicology letters.

Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals.

P. Kasper, L Müller, P Kasper, 2000, Mutation research.

ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.

T Sofuni, L Müller, Y Kikuchi, 1999, Mutation research.

Raffaella Corvi, Lutz Müller, Peter Kasper, 2016, Mutation research. Genetic toxicology and environmental mutagenesis.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Raffaella Corvi, Elizabeth Parry, Lutz Müller, 2007, Mutation research.

Raffaella Corvi, Lutz Müller, Peter Kasper, 2008, Mutation research.

Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes.

G. Williams, J. Parry, D. Kirkland, 2005, Mutation research.

Computational toxicology in drug development.

Wolfgang Muster, Lutz Müller, Alexander Breidenbach, 2008, Drug discovery today.

Genotoxicity testing of peptides: folate deprivation as a marker of exaggerated pharmacology.

T. Singer, C. Schubert, M. Festag, 2014, Toxicology and applied pharmacology.

Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September, 2005.

J. T. Macgregor, M. Hayashi, D. Kirkland, 2007, Mutation research.

The Evolution, Scientific Reasoning and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals

Makoto Hayashi, Lutz Müller, David Tweats, 2013 .

Summary of major conclusions from the 5th IWGT, Basel, Switzerland, 17-19 August 2009.

M. Hayashi, D. Kirkland, P. Kasper, 2011, Mutation research.

The International Workshops on Genotoxicity Testing (IWGT): history and achievements.

J. T. Macgregor, M. Hayashi, D. Kirkland, 2007, Mutation research.

Summary of major conclusions.

J. T. Macgregor, T. Sofuni, M. Hayashi, 1994, Mutation research.

Erratum to “Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity” [Mut. Res. 584 (2005) 1–256]

Lutz Müller, Leigh Henderson, David Kirkland, 2005 .

The Relevance of Photomutagenicity Testing as a Predictor of Photocarcinogenicity

P. Kasper, L. Müller, 1998 .

Considerations regarding a permitted daily exposure calculation for ethyl methanesulfonate.

L. Müller, E. Gocke, 2009, Toxicology letters.

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.

Scott Boyer, Nigel Greene, Lutz Müller, 2013, Regulatory toxicology and pharmacology : RTP.

Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.

Lutz Müller, Peter Kasper, David Tweats, 2003, Mutation research.

Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D

Wolfgang Muster, Lutz Müller, Alexander Breidenbach, 2006 .

Strategies in case of positive in vivo results in genotoxicity testing.

J. T. Macgregor, D. Phillips, M. Moore, 2011, Mutation research.