X. Pei

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Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors

S. Grant, Yun Dai, X. Pei, 2004, Clinical Cancer Research.

The NF (Nuclear factor)‐κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1‐dependent apoptosis in human acute myeloid leukaemia cells

P. Dent, S. Grant, Yun Dai, 2010, British journal of haematology.

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

Jorge A. Almenara, P. Dent, S. Grant, 2011, Blood.

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

John D. Roberts, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

Jorge A. Almenara, P. Dent, S. Grant, 2011, Blood.

Cytokinetically quiescent ( G 0 / G 1 ) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk 1 and MEK 1 / 2

P. Dent, S. Grant, Yun Dai, 2011 .

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.

P. Dent, S. Grant, Yun Dai, 2008, Blood.

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.

P. Dent, S. Grant, Yun Dai, 2007, Blood.

Chemical Therapeutics The Novel Chk 1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair

S. Grant, Yun Dai, Hui Lin, 2013 .

multiple myeloma through a novel link between autophagy and apoptosis A Bim-targeting strategy overcomes adaptive bortezomib-resistance in

S. Grant, Richard J. Jones, R. Orlowski, 2014 .

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.

D. Conrad, P. Dent, S. Grant, 2004, Blood.

Interruption of the NF-B pathway by Bay 11-7082 promotes UCN-01 – mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

D. Conrad, P. Dent, S. Grant, 2003 .

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells.

S. Grant, J. Leverson, M. Rahmani, 2018, Cancer research.

CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.

P. Dent, S. Grant, R. Orlowski, 2012, Cancer research.

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF‐κB and Bim

P. Dent, S. Grant, Yun Dai, 2011, British journal of haematology.

Nonlinear response surface in the study of interaction analysis of three combination drugs

Shumei S. Sun, J. Birch, M. Tan, 2017, Biometrical journal. Biometrische Zeitschrift.

Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells

S. Grant, R. Orlowski, Yun Dai, 2014, PloS one.

Interaction Analysis of Three Combination Drugs via a Modified Genetic Algorithm

Shumei S. Sun, J. Birch, M. Tan, 2014 .

A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis.

Yun Dai, Hui Lin, Yu Zhang, 2014, Blood.

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

Yun Dai, S. Grant, Yun Dai, 2004, Molecular cancer therapeutics.

Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hydroxystaurosporine-Induced Apoptosis in Human Multiple Myeloma Cells

P. Dent, S. Grant, Weiqun Li, 2006, Molecular Pharmacology.

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

P. Dent, S. Grant, M. Rahmani, 2005, Blood.

INTERRUPTION OF BOTH AKT AND MEK / ERK PATHWAYS AND ACTIVATION OF SEK 1 / JNK

P. Dent, S. Grant, M. Rahmani, 2004 .

The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair

Yun Dai, Hui Lin, S. Grant, 2013, Molecular Cancer Therapeutics.

Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1

S. Grant, Yun Dai, X. Pei, 2009, Molecular and Cellular Biology.

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.

P. Dent, S. Grant, M. Rahmani, 2004, Blood.

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

S. Grant, X. Pei, Y. Dai, 2003, Leukemia.

farnesylation and activation lethality in human leukemia and myeloma cells by disrupting Ras Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01)

P. Dent, S. Grant, Yun Dai, 2013 .

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.

P. Dent, S. Grant, Yun Dai, 2007, Blood.

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

P. Dent, S. Grant, H. Harada, 2007, Blood.

Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors*

P. Dent, S. Grant, Yun Dai, 2011, The Journal of Biological Chemistry.

Inhibition of the MAPK and PI3K pathways enhances UDCA‐induced apoptosis in primary rodent hepatocytes

P. Dent, A. Yacoub, S. Grant, 2002, Hepatology.

Experimental design and statistical analysis for three-drug combination studies

Hong-Bin Fang, Xuerong Chen, Ming Tan, 2017, Statistical methods in medical research.

The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6

Y.-R. Dai, X. Pei, Changhui Yan, 1999, Cellular and Molecular Life Sciences CMLS.

The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

P. Dent, S. Grant, M. Rahmani, 2005, Clinical Cancer Research.

Targeting SQSTM1/p62 Induces Cargo Loading Failure and Converts Autophagy to Apoptosis via NBK/Bik

S. Grant, Richard J. Jones, R. Orlowski, 2014, Molecular and Cellular Biology.

Targeting CDK9 Dramatically Potentiates ABT-737-Induced Apoptosis in Human Multiple Myeloma Cells through a Bim-Dependent Mechanism.

Michael L. Wang, P. Dent, S. Grant, 2009 .

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

John D. Roberts, P. Dent, M. Hagan, 2008, Molecular Cancer Therapeutics.

Experimental design and statistical analysis for three-drug combination studies

M. Tan, Hong-Bin Fang, S. Grant, 2017, Statistical methods in medical research.

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF‐κB and Bim

P. Dent, S. Grant, Yun Dai, 2011, British journal of haematology.

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.

Jorge A. Almenara, P. Dent, S. Grant, 2008, Blood.

The MEK1/2 inhibitor AZD6244 (ARRY-142886) interacts synergistically with the novel Chk1 inhibitor AZD7762 to induce apoptosis in human multiple myeloma cells

P. Dent, S. Grant, Yun Dai, 2008 .