Joseph D. Panarese

发表

Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.

Peter Hodder, P. Jeffrey Conn, Craig W. Lindsley, 2015, Bioorganic & medicinal chemistry letters.

Total Synthesis of Aspergillide C

Joseph D. Panarese, S. P. Waters, 2013 .

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

B. Shook, S. Noton, R. Fearns, 2021, PLoS pathogens.

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.

Alison R. Gregro, Julie L. Engers, Anna L. Blobaum, 2018, Bioorganic & medicinal chemistry letters.

Tandem iodine-mediated oxidations of tetrahydro-β-carbolines: total synthesis of eudistomins Y1-Y7.

Joseph D. Panarese, S. P. Waters, 2013, Organic & biomolecular chemistry.

Room-temperature aromatization of tetrahydro-β-carbolines by 2-iodoxybenzoic acid: utility in a total synthesis of eudistomin U.

Joseph D. Panarese, S. P. Waters, 2010, Organic letters.

Biomimetic synthesis and biological evaluation of Aplidiopsamine A.

C. Lindsley, Joseph D. Panarese, 2012, Organic letters.

Enantioselective formal total synthesis of (+)-aspergillide C.

Joseph D. Panarese, S. P. Waters, 2009, Organic letters.

Room-temperature aromatization of tetrahydro-β-carbolines by 2-iodoxybenzoic acid: utility in a total synthesis of eudistomin U.

Joseph D. Panarese, S. P. Waters, 2010, Organic letters.

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.

Alison R. Gregro, Andrew S. Felts, Anna L. Blobaum, 2019, Bioorganic & medicinal chemistry letters.

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4).

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2018, Journal of medicinal chemistry.

Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.

Brittney S. Bates, C. Lindsley, Joseph D. Panarese, 2013, Tetrahedron letters.

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease.

Craig W Lindsley, Bruce J. Melancon, Bruce J Melancon, 2013, Drug discovery today.

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

S. Rani, R. Gaudet, A. Kannt, 2019, Journal of medicinal chemistry.

Allosteric modulation of the M 1 muscarinic acetylcholine receptor : improving cognition and a potential treatment for schizophrenia and Alzheimer ’ s disease

Bruce J. Melancon, C. Lindsley, Joseph D. Panarese, 2013 .

Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease.

Julie L. Engers, Andrew S. Felts, Anna L. Blobaum, 2018, ACS medicinal chemistry letters.

Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.

Anna L. Blobaum, C. Lindsley, P. Conn, 2016, Bioorganic & medicinal chemistry letters.

The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core.

Anna L. Blobaum, C. Lindsley, Hyekyung P. Cho, 2018, Bioorganic & medicinal chemistry letters.

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4).

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2018, Journal of Medicinal Chemistry.