Steven I Dworetzky

4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.

Qi Gao, Nicholas A Meanwell, Yi Li, 2002, Journal of medicinal chemistry.

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.