Xi-Ping Huang

发表

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Feng Liu, Sun-Chong Wang, Jian Jin, 2011, Nature chemical biology.

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Michael J. Keiser, Bryan L Roth, John J Irwin, 2011, Neuropsychopharmacology.

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Bryan L Roth, V. Setola, Xi-Ping Huang, 2010, Assay and drug development technologies.

Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets

Dahlia R. Weiss, Bryan L Roth, Brian K Shoichet, 2018, Journal of medicinal chemistry.

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

David E. Gloriam, John D. McCorvy, Bryan L. Roth, 2018, Cell.

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

Hyunah Choo, Jian Jin, Bryan L. Roth, 2015, ACS chemical neuroscience.

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

Bryan L. Roth, Nicola A. Colabufo, F. Ivy Carroll, 2013, PloS one.

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Alexander Golbraikh, Alexander Tropsha, Christopher M Grulke, 2010, Journal of medicinal chemistry.

A cellular chemical probe targeting the chromodomains of Polycomb Repressive Complex 1

Nancy Cheng, Su Qin, Bradley M Dickson, 2015, Nature chemical biology.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

John D. McCorvy, Bryan L. Roth, Brian K. Shoichet, 2020, Nature.

Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment

Bryan L. Roth, V. Setola, Xi-Ping Huang, 2009, Molecular Pharmacology.

Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2012, Nature.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

Vadim Cherezov, Vsevolod Katritch, Bryan L Roth, 2014, Nature Communications.

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

Bryan L. Roth, Xi-Ping Huang, B. Roth, 2009, Psychopharmacology.

Molecular control of δ-opioid receptor signalling

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2014, Nature.

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Jing Liu, Jian Jin, John D. McCorvy, 2016, Nature chemical biology.

Structure of the human kappa opioid receptor in complex with JDTic

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2012, Nature.

Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.

Niu Huang, Bryan L Roth, Xi-Ping Huang, 2012, Journal of medicinal chemistry.

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists

Anat Levit, Ron O Dror, Bryan L Roth, 2017, Science.

Mutational Disruption of a Conserved Disulfide Bond in Muscarinic Acetylcholine Receptors Attenuates Positive Homotropic Cooperativity between Multiple Allosteric Sites and Has Subtype-Dependent Effects on the Affinities of Muscarinic Allosteric Ligands

John Ellis, Xi-Ping Huang, Xi-Ping Huang, 2007, Molecular Pharmacology.

Structure of the human smoothened receptor bound to an antitumour agent

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2013, Nature.