Timothy A Springer

发表

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

Thomas Walz, Noritaka Nishida, T. Walz, 2011, Nature Structural &Molecular Biology.

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

Motomu Shimaoka, Gang Song, Yong-Sung Kim, 2006, Proceedings of the National Academy of Sciences of the United States of America.

von Willebrand factor, Jedi knight of the bloodstream.

T. Springer, Timothy A Springer, 2014, Blood.

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

Cheng-Zhong Zhang, Wesley P. Wong, T. Springer, 2009, Science.

Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and Signaling*

Wei Wang, Jieqing Zhu, Wei Wang, 2010, The Journal of Biological Chemistry.

Can we reduce the number of fish in the OECD acute toxicity test?

Hans Rufli, T. Springer, H. Rufli, 2011, Environmental toxicology and chemistry.

Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light.

Bing Zhao, Wei Lin, He Li, 2015, Nature nanotechnology.

A high affinity human antibody antagonist of P-selectin mediated rolling.

K Dane Wittrup, T. Springer, K. Wittrup, 2006, Biochemical and biophysical research communications.

Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics.

Ioan Andricioaei, I. Andricioaei, T. Springer, 2004, Structure.

Statistical analysis of histopathological endpoints

T. Springer, John W Green, Timothy A Springer, 2014, Environmental toxicology and chemistry.

α(V)β(3) integrin crystal structures and their functional implications.

T. Springer, Jianghai Zhu, B. Luo, 2012, Biochemistry.

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.

Wei Yang, Motomu Shimaoka, Azucena Salas, 2003, Immunity.

Measurement of selectin tether bond lifetimes.

Shuqi Chen, Timothy A Springer, Ronen Alon, 2002, Biophysical journal.

Structural basis for dimerization of ICAM-1 on the cell surface.

Jia-Huai Wang, Rongguang Zhang, Andrzej Joachimiak, 2004, Molecular cell.

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

Junichi Takagi, C. Carman, J. Takagi, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis of integrin regulation and signaling.

C. Carman, T. Springer, B. Luo, 2007, Annual review of immunology.

Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion*

David Baker, Tanja Kortemme, G. A. Lazar, 2006, Journal of Biological Chemistry.

Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

Noritaka Nishida, T. Springer, T. Xiao, 2008, Molecular cell.

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.

Thomas Walz, Yifan Cheng, Motomu Shimaoka, 2006, Immunity.

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

C. Carman, T. Springer, Timothy A Springer, 2003, Current opinion in cell biology.

A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry.

Luis Mendoza, Eric W Deutsch, Robert L Moritz, 2018, Journal of proteome research.

Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.

Osamu Yoshie, Kouji Matsushima, T. Springer, 2002, Immunity.

Integrin structures and conformational signaling.

T. Springer, B. Luo, Timothy A Springer, 2006, Current opinion in cell biology.

The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

David Baker, Patrick Barth, Jieqing Zhu, 2009, Molecular cell.