M. Hakoda

发表

In vivo mutant T cell frequency in atomic bomb survivors carrying outlying values of chromosome aberration frequencies.

A. Awa, Y. Hirai, S. Kyoizumi, 1988, Mutation research.

Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors

K. Kodama, D. Macphee, F. Kasagi, 2003, International journal of radiation biology.

[Epidemiology of hyperuricemia and gout in Japan].

M. Hakoda, 2008, Nihon rinsho. Japanese journal of clinical medicine.

Low-Positive Antibody Titer against Helicobacter pylori Cytotoxin-Associated Gene A (CagA) May Predict Future Gastric Cancer Better Than Simple Seropositivity against H. pylori CagA or against H. pylori

K. Kodama, E. Tahara, M. Akahoshi, 2007, Cancer Epidemiology Biomarkers & Prevention.

Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment.

H. Yamanaka, N. Kamatani, C. Terai, 1998, Advances in experimental medicine and biology.

Somatic Mutation in Peripheral Lymphocytes of Former Workers at the Okunojima Poison Gas Factory

M. Akiyama, M. Yamakido, M. Hakoda, 1988, Japanese journal of cancer research : Gann.

Monoclonal antibodies to human squamous cell carcinoma of the lung and their application to tumor diagnosis.

S. Jones, M. Yamakido, S. Kyoizumi, 1985, Cancer research.

LTA 252G allele containing haplotype block is associated with high serum C-reactive protein levels.

S. Izumi, N. Takahashi, G. Suzuki, 2004, Atherosclerosis.

Cryopreservation of human lymphocytes for assessment of lymphocyte subsets and natural killer cytotoxicity.

T. Seyama, S. Jones, M. Yamakido, 1986, Journal of immunological methods.

Microchimerism in Japanese patients with systemic sclerosis.

N. Kamatani, M. Hakoda, S. Kotake, 2001, Arthritis and rheumatism.

Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients.

N. Kamatani, N. Udagawa, N. Takahashi, 2001, Arthritis and rheumatism.

Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients.

N. Kamatani, N. Udagawa, N. Takahashi, 2001, Arthritis & Rheumatism.

Rheumatoid Factors Induce Signaling from B Cells, Leading to Epstein-Barr Virus and B-Cell Activation

N. Kamatani, K. Takada, T. Koike, 2004, Journal of Virology.

A chromosome study of 6-thioguanine-resistant mutants in T lymphocytes of Hiroshima atomic bomb survivors.

A. Awa, Y. Kodama, M. Akiyama, 1989, Mutation research.

Association between hypoxanthine concentration in synovial fluid and joint destruction in patients with rheumatoid arthritis

H. Yamanaka, N. Kamatani, M. Hakoda, 1998 .

Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.

N. Kamatani, M. Hakoda, A. Nakajima, 1996, Annals of the rheumatic diseases.

Identification of a compound heterozygote for adenine phosphoribosyltransferase deficiency (APRT*J/APRT*Q0) leading to 2,8-dihydroxyadenine urolithiasis

H. Yamanaka, N. Kamatani, M. Hakoda, 1990, Human Genetics.

Adenine phosphoribosyltransferase deficiency identified by urinary sediment analysis: cellular and molecular confirmation

H. Yamanaka, N. Kamatani, C. Terai, 1995, Clinical genetics.

Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma.

N. Kohno, M. Akiyama, M. Yamakido, 1988, Japanese journal of clinical oncology.

T-Cell Responses to Mitogens in Atomic Bomb Survivors: A Decreased Capacity to Produce Interleukin 2 Characterizes the T Cells of Heavily Irradiated Individuals

K. Kodama, Y. Kusunoki, S. Kyoizumi, 2001, Radiation research.

Clonal analysis of T cell infiltrates in synovial tissue of patients with rheumatoid arthritis.

N. Kamatani, N. Miyasaka, K. Nishioka, 1990, Clinical immunology and immunopathology.

Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes.

A. Awa, M. Yamakido, S. Kyoizumi, 1988, Mutation research.

Divergent effects ofmethotrexate on theclonal growth ofT andBlymphocytes andsynovial adherent cells frompatients withrheumatoid arthritis

H. Yamanaka, N. Kamatani, M. Hakoda, 1996 .

Formation of DNA strand breaks by D-penicillamine and bucillamine in human lymphocytes.

N. Kamatani, D. Carson, M. Hakoda, 1993, Immunopharmacology.

Genetic Basis of the Epidemiological Features and Clinical Significance of Renal Hypouricemia

M. Hakoda, K. Ichida, 2022, Biomedicines.

N. Kamatani, C. Terai, M. Hakoda, 1996, Mutation research.

Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors.

K. Nakachi, F. Kasagi, Y. Kusunoki, 2005, The American journal of medicine.

Molecular basis for the interaction between human IgM and staphylococcal protein A.

N. Kamatani, C. Terai, M. Hakoda, 1994, Clinical immunology and immunopathology.

Cloning of in vivo-derived thioguanine-resistant human B cells.

Y. Kusunoki, Y. Hirai, M. Akiyama, 1989, Mutation research.

Analysis of germline and in vivo somatic mutations in the human adenine phosphoribosyltransferase gene: mutational hot spots at the intron 4 splice donor site and at codon 87.

J. Tischfield, N. Kamatani, P. Stambrook, 1993, Mutation research.

In vitro radiosensitivity of human fresh T-lymphocytes by colony formation assay using PHA and recombinant interleukin-2.

N. Nakamura, M. Akiyama, M. Hakoda, 1987, Journal of radiation research.

Feasibility of Freeze-Dried Sera for Serological and Molecular Biological Detection of Hepatitis B and C Viruses

K. Chayama, S. Fujiwara, M. Yamada, 2006, Journal of Clinical Microbiology.

Molecular Characterization of a Deletion in the HPRT1 Gene in a Patient with Lesch–Nyhan Syndrome

H. Yamanaka, M. Hakoda, Y. Yamada, 2011, Nucleosides, nucleotides & nucleic acids.

Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells

M. Akiyama, H. Yamanaka, N. Kamatani, 1995, Human Genetics.

Lack of association of HLA-DRB1 genotype with radiologic progression in Japanese patients with early rheumatoid arthritis.

M. Hakoda, S. Kashiwazaki, K. Higami, 1997, Arthritis and rheumatism.

A germline mutation abolishing the original stop codon of the human adenine phosphoribosyltransferase (APRT) gene leads to complete loss of the enzyme protein

A. Taniguchi, H. Yamanaka, N. Kamatani, 1998, Human Genetics.

Molecular analyses of in vivo hprt mutant T cells from atomic bomb survivors

M. Akiyama, Y. Hirai, S. Kyoizumi, 1989, Environmental and molecular mutagenesis.

Studies on chromosome aberrations and HPRT mutations in lymphocytes and GPA mutation in erythrocytes of atomic bomb survivors.

A. Awa, N. Nakamura, Y. Hirai, 1990, Progress in clinical and biological research.

Increased somatic cell mutant frequency in atomic bomb survivors.

M. Akiyama, A. Awa, M. Yamakido, 1988, Mutation research.

The 38th Board of Directors Meeting

K. Nakachi, G. Suzuki, Y. Kusunoki, 2004 .

Detection of somatic mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors using a single beam flow sorter.

M. Akiyama, R. Jensen, A. Awa, 1989, Cancer research.

Crossovers within a short DNA sequence indicate a long evolutionary history of the APRT*J mutation

N. Kamatani, T. Palella, M. Hakoda, 1990, Human Genetics.

Detection of the most common mutation of adenine phosphoribosyltransferase deficiency among Japanese by a non-radioactive method.

N. Kamatani, R. Kawaguchi, M. Hakoda, 1991, Clinica chimica acta; international journal of clinical chemistry.

Diagnosis of genotypes for adenine phosphoribosyltransferase (APRT) deficiency.

N. Kamatani, K. Nishioka, C. Terai, 1989, Advances in experimental medicine and biology.

Cloning of phenotypically different human lymphocytes originating from a single stem cell

Y. Kodama, Y. Kusunoki, Y. Hirai, 1989, The Journal of experimental medicine.

Individual variation of somatic gene mutability in relation to cancer susceptibility: prospective study on erythrocyte glycophorin a gene mutations of atomic bomb survivors.

Tomonori Hayashi, Kei Nakachi, Yoichiro Kusunoki, 2005, Cancer research.

Clinical practice guideline for renal hypouricemia (1st edition)

I. Hisatome, N. Shinomiya, K. Ogino, 2019, Human Cell.

Diagnosis of heterozygous states for adenine phosphoribosyltransferase deficiency based on detection of in vivo somatic mutants in blood T cells: application to screening of heterozygotes.

H. Yamanaka, N. Kamatani, M. Hakoda, 1991, American journal of human genetics.

Urine alkalization facilitates uric acid excretion

I. Seyama, M. Hakoda, A. Kanbara, 2010, Nutrition journal.

Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide.

K. Tokunaga, N. Kamatani, N. Tsuchiya, 2007, Clinical and experimental rheumatology.

Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.

N. Kamatani, I. Matsumoto, T. Sumida, 2008, Clinical and experimental rheumatology.

Generation and molecular characterisation of monoclonal IgG4 rheumatoid factor from a patient with rheumatoid arthritis

A. Taniguchi, H. Yamanaka, N. Kamatani, 1997, Annals of the rheumatic diseases.

Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis

N. Kamatani, M. Hakoda, T. Furuya, 2007, Clinical Rheumatology.

Association of HLA class I and class II alleles with myositis in Japanese patients.

K. Tokunaga, N. Kamatani, N. Tsuchiya, 1998, The Journal of rheumatology.

Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus

H. Yamanaka, N. Kamatani, C. Terai, 1997, Human Genetics.

The origin of the most common mutation of adenine phosphoribosyltransferase among Japanese goes back to a prehistoric era

H. Yamanaka, N. Kamatani, C. Terai, 1996, Human Genetics.

Levels of Antibodies to Microorganisms Implicated in Atherosclerosis and of C-Reactive Protein among Atomic Bomb Survivors

K. Kodama, M. Akahoshi, S. Fujiwara, 2006, Radiation research.

Uneven Distributions of Naïve and Memory T Cells in the CD4 and CD8 T-Cell Populations Derived from a Single Stem Cell in an Atomic Bomb Survivor: Implications for the Origins of the Memory T-Cell Pools in Adulthood

Y. Kusunoki, Y. Hirai, S. Kyoizumi, 2002, Radiation research.

Glycophorin A Gene Mutations of Atomic Bomb Survivors Cancer Susceptibility : Prospective Study on Erythrocyte Individual Variation of Somatic Gene Mutability in Relation to

J. Cologne, K. Nakachi, Y. Kusunoki, 2005 .

Analysis of peripheral blood lymphocytes of atomic bomb survivors using monoclonal antibodies.

S. Jones, G. B. Olson, S. Kyoizumi, 1986, Journal of radiation research.

Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study

H. Oiwa, F. Kasagi, G. Suzuki, 2005, Annals of the rheumatic diseases.

Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis.

K. Chayama, M. Akahoshi, E. Nakashima, 2011, Human immunology.

Effects of Menstrual Cycle Phase on Fluid Regulation during Walking Exercise.

M. Hakoda, Takuma Wada, Kazuki Nishimura, 2020, Journal of sports science & medicine.

Serum uric acid concentration as a risk factor for cardiovascular mortality: a longterm cohort study of atomic bomb survivors.

K. Kodama, S. Fujiwara, F. Kasagi, 2005, The Journal of rheumatology.

Germline and somatic mutations leading to adenine phosphoribosyltransferase (APRT) deficiency.

N. Kamatani, M. Hakoda, S. Kashiwazaki, 1991, Advances in experimental medicine and biology.

Increasing trend of asymptomatic hyperuricemia under treatment with urate-lowering drugs in Japan

F. Kasagi, M. Hakoda, 2018, Modern rheumatology.

KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases.

N. Kamatani, H. Nakajima, F. Sakai, 2000, The Journal of rheumatology.

Analysis of the genotypes for aldehyde dehydrogenase 2 in Japanese patients with primary gout.

N. Kamatani, R. Kawaguchi, C. Terai, 1994, Advances in experimental medicine and biology.

Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy.

T. Mimori, K. Tokunaga, N. Kamatani, 2004, The Journal of rheumatology.

Somatic cell mutations in atomic bomb survivors.

N. Nakamura, Y. Kusunoki, Y. Hirai, 1991, Journal of radiation research.

Only three mutations account for almost all defective alleles causing adenine phosphoribosyltransferase deficiency in Japanese patients.

H. Yoshikawa, N. Kamatani, M. Hakoda, 1992, The Journal of clinical investigation.

Optimal range of serum urate concentrations to minimize risk of gouty attacks during antihyperuricemic treatment

N. Kamatani, C. Terai, M. Hakoda, 1997 .

Recent trends in hyperuricemia and gout in Japan.

M. Hakoda, 2012, Japan Medical Association journal : JMAJ.

Homozygous deficiency at autosomal locus aprt in human somatic cells in vivo induced by two different mechanisms.

N. Kamatani, K. Nishioka, N Kamatani, 1990, Cancer research.

Combining effects of polymorphism of tumor necrosis factor α 5′-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis

K. Tokunaga, N. Kamatani, A. Kawasaki, 2009, Modern rheumatology.

Combining effects of polymorphism of tumor necrosis factor α 5′-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis

Katsushi Tokunaga, Naoyuki Kamatani, K. Tokunaga, 2009, Modern rheumatology.

Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis

N. Kamatani, M. Hakoda, T. Furuya, 2007, Clinical Rheumatology.

Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients.

N. Kamatani, N. Udagawa, N. Takahashi, 2001, Arthritis and rheumatism.