A. Smith

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A stereospecific total synthesis of (+/-)-methylenomycin A. A novel antibiotic possessing an alpha-methylene ketone functionality.

R. M. Scarborough, A. Smith, A. Smith, 1977, Journal of the American Chemical Society.

De Novo Design and Synthesis of Somatostatin Non‐Peptide Peptidomimetics Utilizing β‐D‐Glucose as a Novel Scaffolding.

C. Donaldson, C. Strader, R. Freidinger, 1994 .

Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.

A B Smith, C. Strader, M. Cichy-Knight, 1996, Journal of medicinal chemistry.

Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.

A B Smith, M. Cichy-Knight, W. Shakespeare, 1998, Journal of medicinal chemistry.

Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.

D. Underwood, R. Hirschmann, A. Smith, 2000, Journal of Medicinal Chemistry.

Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.

L. M. Atkins, M. Jones, A. Smith, 1994, Toxicology.

Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid.

L. M. Atkins, M. Jones, A. Smith, 1992, Toxicology.

Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels.

O. McManus, M. Garcia-Calvo, J. Reuben, 1994, Biochemistry.

Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide formation and receptor affinity.

A. Lender, R. Hirschmann, W. Yao, 2009, International journal of peptide and protein research.

Intramolecular hydrogen-bond participation in phosphonylammonium salt formation.

R. Hirschmann, A. Smith, L. Ducry, 2000, Organic letters.

Potential role of a conducting polymer in biochemistry : protein-binding properties

C. J. Knowles, C. Knowles, A. B. Smith, 1990 .

Diethyldithiocarbamate in treatment of acute cadmium poisoning.

A. Smith, E. Walker, G. Gale, 1981, Annals of clinical and laboratory science.

Identification of haptoglobin as a natural inhibitor of trypanocidal activity in human serum.

S. Hajduk, A. Smith, A. Smith, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Effects of diethyldithiocarbamate and selected analogs on lead metabolism in mice.

L. M. Atkins, M. Jones, A. Smith, 1986, Research communications in chemical pathology and pharmacology.

Design and synthesis of novel scaffolds for drug discovery: hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines.

R. Hirschmann, A. Smith, J. Hynes, 2001, Organic letters.

Killing of trypanosomes by the human haptoglobin-related protein.

S. Hajduk, J. Esko, A. Smith, 1995, Science.

MEASUREMENTS OF THE RELATIVE CHEMICAL REACTIVITY OF TRIPLET SPIN SUBSTATES

R. Hochstrasser, B. Dellinger, A. Smith, 1977 .

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.

Amos B. Smith, S. Horwitz, M. LaMarche, 2001, Chemistry & biology.

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.

G. Macdonald, K. Thewlis, G. Riley, 2001, Bioorganic & Medicinal Chemistry Letters.

Schedule dependency of a cadmium-complexing dithiocarbamate analog in mice.

L. M. Atkins, M. Jones, A. Smith, 1990, Toxicology letters.

N,N-disubstituted dithiocarbamates as cadmium antagonists: N-(4-methoxybenzyl)-N-dithiocarboxy-D-glucamine.

L. M. Atkins, M. Jones, A. Smith, 1989, Toxicology letters.

Cadmium mobilization by monoaralkyl- and monoalkyl esters of meso-2,3-dimercaptosuccinic acid and by a dithiocarbamate.

M. Jones, A. Smith, P. Singh, 1994, Pharmacology & toxicology.

Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.

L. M. Atkins, M. Jones, A. Smith, 1992, Pharmacology & toxicology.

Oleocanthal inhibits proliferation and MIP-1α expression in human multiple myeloma cells.

J. Gómez-Reino, R. Gómez, O. Gualillo, 2013, Current medicinal chemistry.

A stereospecific total synthesis of (.+-.)-methylenomycin A and its epimer, (.+-.)-epimethylenomycin A

R. M. Scarborough, A. Smith, B. H. Toder, 1980 .

Activity of Selected 2,4-Diaminoquinazolines against Candida albicans in Vitro 1

A. Smith, L. Hough, J. Hynes, 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Total Synthesis of (−)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction

S. Kozmin, A. Smith, C. Adams, 2001 .

On the reversible nature of the olefin cross metathesis reaction.

S. Kozmin, A. Smith, C. Adams, 2001, Journal of the American Chemical Society.

Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold.

P. Carroll, R. Hirschmann, P. Sprengeler, 1999, Bioorganic & medicinal chemistry.

Lituarine synthetic studies. An efficient, stereocontrolled construction of the common c(7-19) tricyclic spiroketal fragment.

A. Smith, M. Frohn, A. Smith, 2001, Organic letters.

Total synthesis of (+)-zampanolide.

A. Smith, I. Safonov, R. M. Corbett, 2001, Journal of the American Chemical Society.

Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement.

P. Verhoest, M. Schelhaas, K. Minbiole, 2001, Journal of the American Chemical Society.

Total synthesis of the ansamycin antibiotic (+)-thiazinotrienomycin E.

A. Smith, Z. Wan, A. Smith, 2000, The Journal of organic chemistry.

Total synthesis of (+)-thiazinotrienomycin E.

A. Smith, Z. Wan, 1999, Organic letters.

Chromium(II) Reagents. Part 1. Reduction of α-Acetylenic Ketones to trans-Enones.

A. Smith, P. Levenberg, J. Z. Suits, 1986 .

Synthesis of polypyrrolinones on solid support.

A B Smith, R. Hirschmann, R Hirschmann, 2000, Organic letters.

A second-generation synthesis of polypyrrolinone nonpeptidomimetics: prelude to the synthesis of polypyrrolinones on solid support.

R. Hirschmann, A. Smith, H. Liu, 2000, Organic letters.

β,Γ-UNSATURATED DIAZO KETONES. A NEW INITIATOR FOR POLYOLEFINIC CATIONIC CYCLIZATION

A. Smith, R. Dieter, A. Smith, 1977 .

Development of an efficient, regio- and stereoselective route to libraries based on the beta-D-glucose scaffold.

R. Hirschmann, A. Smith, L. Ducry, 2000, The Journal of organic chemistry.

Total Synthesis of (+)‐Hydroxyjatrophone A and (+)‐Hydroxyjatrophone B.

Kwunmin Chen, A. Smith, M. Ohba, 1989 .

Total synthesis of (+)-latrunculin B.

N. Liverton, A. Smith, R. Zibuck, 1986, Journal of the American Chemical Society.

Phorboxazole synthetic studies. 1. Construction of a C(3-19) subtarget exploiting an extension of the Petasis-Ferrier rearrangement.

P. Verhoest, K. Minbiole, A. Smith, 1999, Organic letters.

Phorboxazole synthetic studies. 2. Construction of a C(20-28) subtarget, a further extension of the Petasis-Ferrier rearrangement.

P. Verhoest, K. Minbiole, A. Smith, 1999, Organic letters.

Total synthesis of (+)-phorboxazole A.

P. Verhoest, M. Schelhaas, K. Minbiole, 1998, Journal of the American Chemical Society.

Tremorgenic indole alkaloids. Studies directed toward the assembly of the A, F, and I rings of penitrem D: observation of an unexpected stereochemical outcome.

N. Minakawa, J. Rainier, N. Kanoh, 1999, Organic letters.

Antitumor and Antimitogenic Properties of the Photochemical Reaction Product of Ammonium Hexachloroiridate(IV) 1

A. Smith, E. Walker, G. Gale, 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase.

B. Cooperman, R. Hirschmann, J. Barbosa, 1998, Bioorganic & medicinal chemistry letters.

Cyclic peptide formation catalyzed by an antibody ligase.

S. Benkovic, J. Liu, S. Iwama, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of diethyldithiocarbamate, dihydroxyethyldithiocarbamate, and dicarboxymethyldithiocarbamate action of distribution and excretion of cadmium.

L. M. Atkins, M. Jones, A. Smith, 1983, Annals of clinical and laboratory science.

Nodulisporic acid A synthetic studies. 1. Overall strategy and construction of a western hemisphere subtarget.

H. Ishiyama, A. Smith, Y. S. Cho, 2001, Organic letters.

A practical synthesis of Nalpha-Fmoc-L-pyrazinylalanine via Schöllkopf's chiral auxiliary.

R. Hirschmann, E. Thornton, A. Smith, 2008, The journal of peptide research : official journal of the American Peptide Society.

Binding of an antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents.

L. M. Atkins, A. Smith, G. Gale, 1973, Cancer research.

Nodulisporic acid A synthetic studies. 2. Construction of an eastern hemisphere subtarget.

H. Ishiyama, A. Smith, Y. S. Cho, 2001, Organic letters.

Comparative effects of three dialkyldithiocarbamates on acute toxicity, organ distribution, and excretion of cadmium.

L. M. Atkins, A. Smith, J. Hynes, 1983, Annals of clinical and laboratory science.

435. The synthesis of some cyclic hydroxamic acids from o-aminocarboxylic acids

A. Smith, D. Harrison, 1960 .

Comparative iron mobilizing actions of deferoxamine, 1,2-dimethyl-3-hydroxypyrid-4-one, and pyridoxal isonicotinoyl hydrazone in iron hydroxamate-loaded mice.

M. Jones, R. A. Campbell, A. Smith, 1991, Research communications in chemical pathology and pharmacology.

Effects of hydroxamic acids on L-histidine carboxy-lyase.

L. M. Atkins, A. Smith, G. Gale, 1970, Biochemical pharmacology.

Chemotherapy of advanced L1210 leukemia with platinum compounds in combination with other antitumor agents.

L. M. Atkins, A. Smith, E. Walker, 1977, Cancer treatment reports.

Isomerization Processes of Electronically Excited Stilbene and Diphenylbutadiene in Liquids: Are They One-Dimensional?

R. Hochstrasser, Minyung Lee, A. Smith, 1989 .

The rate of the in vivo dithiocarbamate-induced mobilization of hepatic and renal cadmium deposits.

M. Jones, A. Smith, P. Singh, 1989, Toxicology.

Mechanistic aspects of the dithiocarbamate-induced mobilization of cadmium.

M. Jones, A. Smith, G. Gale, 1989, Journal of inorganic biochemistry.

Effects of diethyldithiocarbamate and N-methyl-N-dithiocarboxyglucamine on murine hepatic cadmium-metallothionein in vitro.

L. M. Atkins, M. Jones, A. Smith, 1985, Research communications in chemical pathology and pharmacology.

Monoisoamyl meso-2,3-dimercaptosuccinate: interaction with metallothionein-bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo.

M. Jones, A. Smith, P. Singh, 1992, Research communications in chemical pathology and pharmacology.

Chemical and Bacteriological Studies of the Photochemical Reaction Product of Ammonium Hexachloroiridate(IV) 1

A. Smith, G. Gale, J. Howle, 1970, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.

R. Hirschmann, J. Duan, P. Sprengeler, 2000, Organic letters.

Multicomponent linchpin couplings of silyl dithianes: synthesis of the Schreiber C(16-28) trisacetonide subtarget for mycoticins A and B.

A. Smith, S. Pitram, A. Smith, 1999, Organic letters.

Solution structure of (+)-discodermolide.

M. LaMarche, A. Smith, M. Falcone-Hindley, 2001, Organic letters.

Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.

S. Danishefsky, T. Pettus, S. Horwitz, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Selective inhibition by sorbylhydroxamic acid of deoxyribonucleic acid synthesis in Ehrlich ascites tumor cells.

A. Smith, E. Walker, G. Gale, 1970, Cancer research.

Alanosine and hadacidin--comparison of effects on adenylosuccinate synthetase.

A. Smith, G. Gale, A. Smith, 1968, Biochemical pharmacology.

The microbial community associated with Montacuta ferruginosa, a commensal bivalve of the echinoid Echinocardium cordatum

C. Ridder, D. Gillan, A. Smith, 1995 .

Identification and characterization of an Onchocerca volvulus cDNA clone encoding a microfilarial surface-associated antigen.

A. Prince, S. Lustigman, B. Brotman, 1992, Molecular and biochemical parasitology.

The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.

A B Smith, R. Hirschmann, P. Sprengeler, 1996, Bioorganic & medicinal chemistry.

HDL-independent lysis of trypanosoma brucei brucei by human serum

S. Hajduk, A. Smith, Stephen L. Hajduk, 1995 .

Chirality, charge, and chain branching effects on dithiocarbamate-induced mobilization of cadmium from intracellular deposits in mice.

L. M. Atkins, M. Jones, A. Smith, 1991, Chemical research in toxicology.

Effect of chelating agent structure on the mobilization of cadmium from intracellular deposits.

L. M. Atkins, M. Jones, R. Bulman, 1989, Journal of toxicology and environmental health.

Effects of monoalkyl dithiocarabamates on mobilization of cadmium in the mouse.

L. M. Atkins, M. Jones, A. Smith, 1986, Journal of toxicology and environmental health.

First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.

R. Hirschmann, A. Smith, G. Pettit, 2001, Organic letters.

Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.

A. Smith, G. Pettit, J. Chapuis, 1998, Bioorganic & medicinal chemistry letters.

Preparation and antitumor evaluation of water-soluble derivatives of dichloro(1,2-diaminocyclohexane)platinum(II).

L. M. Atkins, A. Smith, E. Walker, 1977, Cancer treatment reports.

Combination chemotherapy of L1210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents.

L. M. Atkins, A. Smith, E. Walker, 1976, Journal of the National Cancer Institute.

A proposed mode of action of antitumor platinum compounds based upon studies with cis-dichloro-((G- 3 H)dipyridine)platinum(II).

A. Smith, G. Gale, J. Howle, 1972, Biochemical pharmacology.

Synthesis of tedanolide and 13-deoxytedanolide. Assembly of a common C(1)-C(11) subtarget.

A. Smith, S. A. Lodise, A. Smith, 1999, Organic letters.

Comparative effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate on organ distribution and excretion of cadmium.

L. M. Atkins, A. Smith, E. Walker, 1983, Annals of clinical and laboratory science.

Effects of combined treatment with diethyldithiocarbamate and diethylenetriaminepentaacetate on organ distribution and excretion of cadmium.

L. M. Atkins, A. Smith, E. Walker, 1983, Annals of clinical and laboratory science.

Comparative effects of parenteral and oral administration of selected dithiocarbamates on body burdens and organ distribution of cadmium in mice.

L. M. Atkins, M. Jones, A. Smith, 1986, Research communications in chemical pathology and pharmacology.

Comparative antidotal effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate against cadmium-induced testicular toxicity in mice.

L. M. Atkins, E. Fody, M. Jones, 1986, Research communications in chemical pathology and pharmacology.

Effects of diethyldithiocarbamate and selected analogs on cadmium metabolism following chronic cadmium ingestion.

L. M. Atkins, M. Jones, A. Smith, 1985, Research communications in chemical pathology and pharmacology.

Effects of substituted dithiocarbamates on the testicular toxicity of cadmium.

L. M. Atkins, W. Greene, M. Jones, 1984, Research communications in chemical pathology and pharmacology.

Effects of combined treatment with diethyldithiocarbamate and dihydroxyethyldithiocarbamate on distribution and excretion of cadmium.

A. Smith, E. Walker, G. Gale, 1983, Research communications in chemical pathology and pharmacology.

Factors influencing cadmium mobilization by diethyldithiocarbamate: chelator dose, cadmium burden, and sex.

L. M. Atkins, A. Smith, E. Walker, 1983, Annals of clinical and laboratory science.

Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.

P. Schiller, C. Lemieux, N. N. Chung, 2000, Journal of medicinal chemistry.

Mobilization of lead by esters of meso-2,3-dimercaptosuccinic acid.

L. M. Atkins, M. Jones, A. Smith, 1989, Journal of toxicology and environmental health.

The mobilization of intracellular cadmium by butyl and amyl esters of meso-2,3-dimercaptosuccinic acid.

L. M. Atkins, M. Jones, A. Smith, 1989, Toxicology and applied pharmacology.

Antitumor action of cis-dichlorobis(methylamine)platinum(II).

L. M. Atkins, M. Rosenblum, A. Smith, 1973, Journal of the National Cancer Institute.

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.

P. Darke, E. Emini, R. Hirschmann, 1994, Journal of medicinal chemistry.

Synthesis and biological activity of cyclic peptide inhibitors of ribonucleotide reductase.

B. Cooperman, J. Barbosa, A. Smith, 1999, Organic letters.

Antileukemic properties of organoplatinum complexes.

L. M. Atkins, M. Rosenblum, A. Smith, 1976, Journal of the National Cancer Institute.

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.

J Q Trojanowski, A B Smith, J. Trojanowski, 2011, Current topics in medicinal chemistry.