K. Kühlcke

发表

Retroviral transduction of T lymphocytes for suicide gene therapy in allogeneic stem cell transplantation

A. Zander, B. Fehse, A. Fauser, 2000, Bone Marrow Transplantation.

Establishment of an optimised gene transfer protocol for human primary T lymphocytes according to clinical requirements

A. Zander, B. Fehse, K. Kühlcke, 1999, Gene Therapy.

Murine Leukemia Induced by Retroviral Gene Marking

C. von Kalle, B. Fehse, Johann Meyer, 2002, Science.

Excision of specific DNA-sequences from integrated retroviral vectors via site-specific recombination.

J. Bergemann, B. Fehse, W. Ostertag, 1995, Nucleic acids research.

Optimization of retroviral vector generation for clinical application

K. Kühlcke, A. Schilz, H. Eckert, 2001, The journal of gene medicine.

Genetic protection of repopulating hematopoietic cells with an improved MDR1‐retrovirus allows administration of intensified chemotherapy following stem cell transplantation in mice

A. Zander, D. Hossfeld, W. Ostertag, 2002, International journal of cancer.

Gene therapy for Wiskott-Aldrich syndrome-long - Term efficacy and genotoxicity (Science Translational Medicine)

D. Steinemann, A. Schambach, W. Al-Herz, 2014 .

Real-time quantitative Y chromosome-specific PCR (QYCS-PCR) for monitoring hematopoietic chimerism after sex-mismatched allogeneic stem cell transplantation.

N. Kröger, A. Zander, B. Fehse, 2001, Journal of hematotherapy & stem cell research.

numbers in single cells with gene transfer efficiency in a cell population Dose finding with retroviral vectors: correlation of retroviral vector copy

A. Zander, B. Fehse, C. Baum, 2013 .

Homodimeric murine interleukin-3 agonists indicate that ligand dimerization is important for high-affinity receptor complex formation.

H. Lother, A. Gessner, K. Kühlcke, 1994, Growth factors.

Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice.

C. Baum, W. Zeller, S. Fruehauf, 2002, Human gene therapy.

Protection of hematopoietic cells from chemotherapy-induced toxicity by multidrug resistance-I gene transfer followed by analysis of retroviral insertion sites into the human genome

E. Buss, S. Naundorf, W. Zeller, 2003 .

Highly efficient retroviral gene transfer based on centrifugation-mediated vector preloading of tissue culture vessels.

A. Zander, S. Loges, B. Fehse, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Retroviral transfer of the human multidrug resistance-1 gene in human mobilized peripheral blood progenitor cells engrafting in NOD / SCID mice can confer chemoprotection

E. Buss, B. Schiedlmeier, C. Baum, 2002 .

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

Yang Du, Manuel Grez, Hanno Glimm, 2006, Nature Medicine.

Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

Michael Rothe, Christof von Kalle, Raffaele Fronza, 2014, Science Translational Medicine.

From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease.

C. von Kalle, A. Schambach, M. Dinauer, 2013, Human gene therapy. Clinical development.

Stem-cell gene therapy for the Wiskott-Aldrich syndrome.

Christof von Kalle, Christoph Klein, Rainer Blasczyk, 2010, The New England journal of medicine.

Cell and virus genetics at the roots of gene therapy, retrovirology, and hematopoietic stem cell biology: Wolfram Ostertag (1937-2010).

A. Schambach, V. Prassolov, A. Zander, 2010, Human gene therapy.

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

Hans Martin, Barbara Burwinkel, Rongxi Yang, 2010, Nature Medicine.

Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.

A. Jauch, E. Seifried, W. Wels, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Cloning of retroviral insertion sites possibly involved in growth-factor autonomy

J. Bergemann, B. Fehse, C. Stocking, 1996 .

Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice.

B. Schiedlmeier, C. Baum, W. Zeller, 2000, Blood.

MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions.

M. Grez, B. Schiedlmeier, C. Baum, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

M. Battegay, T. Kündig, M. Bachmann, 1995, Science.

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Oliver J. Klein, Ö. Türeci, U. Şahin, 2020, Science.

Human multidrug resistance-1 gene transfer to long-term repopulating human mobilized peripheral blood progenitor cells

B. Schiedlmeier, C. Baum, W. Zeller, 2000, Bone Marrow Transplantation.

Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1)

C. Baum, A. Fauser, K. Kühlcke, 2000, Bone Marrow Transplantation.

The Express Drivers: Chimeric Antigen Receptor-Redirected T Cells Make It to the Clinic

W. Wels, H. Abken, K. Kühlcke, 2014 .

Evidence for increased risk of secondary graft failure after in vivo depletion of suicide gene-modified T lymphocytes transplanted in conjunction with CD34+-enriched blood stem cells.

N. Kröger, A. Zander, B. Fehse, 2004, Blood.

Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial

R. Guest, F. Thistlethwaite, D. Gilham, 2014, Cancer Immunology, Immunotherapy.

A novel ‘sort-suicide’ fusion gene vector for T cell manipulation

P. Tiberghien, B. Fehse, C. Baum, 2002, Gene Therapy.

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus

A. Schambach, G. Margison, Zhixiong Li, 2006, Gene Therapy.

Intermolecular cystine-bonding of murine interleukin 2 indicates that ligand dimerization is important for the formation of the high-affinity receptor complex.

H. Lother, A. Gessner, K. Kühlcke, 1992, Growth factors.

Detection and spatial distribution of IL-2 receptors on mouse T-lymphocytes by immunogold-labeled ligands.

G. Rutter, H. Lother, H. Hohenberg, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Efficacy of Gene Therapy for Wiskott-Aldrich-Syndrome

W. Al-Herz, C. Klein, A. Schwarzer, 2011 .

Successful Combination of Sequential Gene Therapy and Rescue Allo-HSCT in Two Children with X-CGD - Importance of Timing.

J. Tchinda, A. Jauch, M. Grez, 2015, Current gene therapy.

CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial

Ö. Türeci, U. Şahin, W. Alsdorf, 2023, Nature Medicine.