J. Gallin

S. Holland, D. Kuhns, G. Uzel, 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft.

S. Holland, A. Barrett, R. Childs, 2001, The New England journal of medicine.

Phagocyte Function and Dysfunction: From Descriptive Biology to Molecular Defects and Cytokine Therapy

J. Gallin, 2001 .

Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency.

E. Buescher, J. Gallin, J. Nath, 1985, Blood.

Separation and functional characterization of human neutrophil subpopulations.

M. Klempner, J. Gallin, 1978, Blood.

Neutrophil activation studied using the two indirect probes of membrane potential which respond by different fluorescence mechanisms.

B. Seligmann, J. Gallin, 1982, Advances in experimental medicine and biology.

Neutrophil degranulation and abnormal chemotaxis after thermal injury.

J. Davis, P. Dineen, J. Gallin, 1980, Journal of immunology.

Fletcher factor deficiency. A diminished rate of Hageman factor activation caused by absence of prekallikrein with abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation.

A. Kaplan, J. Gallin, A. .. Weiss, 1974, The Journal of clinical investigation.

Disease Dysregulation in Chronic Granulomatous Production by Hydrogen Peroxide and Inhibition of Human Neutrophil IL-8 Alvord and

W. Alvord, D. Kuhns, J. Gallin, 2004 .

Inflammation: Basic Principles and Clinical Correlates

John I. Gallin, Ralph Snyderman, R. Snyderman, 1992 .

Exudation primes human and guinea pig neutrophils for subsequent responsiveness to the chemotactic peptide N-formylmethionylleucylphenylalanine and increases complement component C3bi receptor expression.

B. Seligmann, W. Zimmerli, J. Gallin, 1986, The Journal of clinical investigation.

Delayed eruption of permanent teeth in hyperimmunoglobulinemia E recurrent infection syndrome.

S. Holland, J. Puck, B. Grimbacher, 2000, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

Itraconazole to prevent fungal infections in chronic granulomatous disease.

D. Alling, S. Holland, M. Turner, 2003, The New England journal of medicine.

Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).

S. Holland, D. Kastner, M. Turner, 2012, Arthritis and rheumatism.

Successful treatment of Paecilomyces varioti infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections.

P. Williamson, K. Kwon-Chung, J. Gallin, 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Adaptation of human neutrophil responsiveness to the chemoattractant N-formylmethionylleucylphenylalanine. Heterogeneity and/or negative cooperative interaction of receptors.

B. Seligmann, M. P. Fletcher, J. Gallin, 1982, The Journal of biological chemistry.

Treatment of infectious and neoplastic diseases with transfer factor.

C. Kirkpatrick, J. Gallin, 1974, Oncology.

X‐linked carriers of chronic granulomatous disease: Illness, lyonization, and stability

S. Holland, S. Rosenzweig, D. Kuhns, 2018, The Journal of allergy and clinical immunology.

Assessment of Atherosclerosis in Chronic Granulomatous Disease

D. Bluemke, S. Holland, E. Turkbey, 2014, Circulation.

Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease

B. Soule, K. Zarember, J. Gallin, 2010 .

Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

Richard B. Johnston, John I. Gallin, Harry L. Malech, 2000, Medicine.

A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group.

John I. Gallin, Harry L. Malech, H. Malech, 1991, The New England journal of medicine.

Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system.

W. Nauseef, R. Clark, D. W. Pearson, 1989, The New England journal of medicine.

Disorders of phagocyte chemotaxis.

J. Davis, M. Klempner, C. Kirkpatrick, 1980, Annals of internal medicine.

Invasive infection with Sarcinosporon inkin in a patient with chronic granulomatous disease.

K. Kwon-Chung, F. Witebsky, J. Gallin, 1990, American journal of clinical pathology.

Current concepts: immunology. Neutrophils in human diseases.

J I Gallin, J. Gallin, H L Malech, 1987, The New England journal of medicine.

Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome.

J. Bennett, A. Macher, J. Gallin, 1984, Gastroenterology.

Neutrophil specific granules: a fuse that ignites the inflammatory response.

J. Gallin, 1984, Clinical research.

Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease.

D. Kuhns, King C. Chan, H. Malech, 2010, Blood.

IFN-gamma is effective in reducing infections in the mouse model of chronic granulomatous disease (CGD).

S. Holland, G. Miller, M. Mardiney, 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Genetic, biochemical, and clinical features of chronic granulomatous disease.

S. Holland, H. Malech, T. Leto, 2000, Medicine.

The p47phox mouse knock-out model of chronic granulomatous disease

S. Holland, J. Gallin, S. H. Jackson, 1995, Journal of Experimental Medicine.

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder.

S. Holland, J. Puck, B. Grimbacher, 1999, The New England journal of medicine.

In vivo interferon-gamma therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae.

H. Malech, J. Rex, J. Bennett, 1991, The Journal of infectious diseases.

Interferon-gamma in the management of chronic granulomatous disease.

J. Gallin, 1991, Reviews of infectious diseases.

STAT3 mutations in the hyper-IgE syndrome.

Bodo Grimbacher, Alejandro A Schäffer, Adeline R. Whitney, 2007, The New England journal of medicine.

Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src.

H. Malech, W. Nauseef, T. Leto, 1990, Science.

Alloimmunization after granulocyte transfusions

D. Stroncek, S. Leitman, J. Gallin, 1996, Transfusion.

Mobilization and exocytosis of specific (secondary) granules by human neutrophils during adherence to nylon wood in filtration leukapheresis (FL).

A. Deisseroth, J. Gallin, D. Wright, 1978, Blood.

Mononuclear cells from patients with the hyperimmunoglobulin E-recurrent infection syndrome produce an inhibitor of leukocyte chemotaxis.

J. Gallin, H. Donabedian, 1982, The Journal of clinical investigation.

Abnormal phagocyte chemotaxis: pathophysiology, clinical manifestations, and management of patients.

J I Gallin, J. Gallin, 1981, Reviews of infectious diseases.

THE REGULATORY ROLE OF DIVALENT CATIONS IN HUMAN GRANULOCYTE CHEMOTAXIS

J. Gallin, A. Rosenthal, 1974, Journal of Cell Biology.

Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease.

S. Holland, J. Hoofnagle, T. Liang, 2008, Gastroenterology.

Burkholderia pseudomallei infection in a Puerto Rican patient with chronic granulomatous disease: case report and review of occurrences in the Americas.

S. Dorman, S. Holland, V. Gill, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Severe Burkholderia (Pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases.

S. Holland, V. Gill, J. Gallin, 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The Changing Paradigm of Management of Liver Abscesses in Chronic Granulomatous Disease

S. Holland, D. Kuhns, G. Uzel, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Common severe infections in chronic granulomatous disease.

S. Holland, S. Rosenzweig, D. Kuhns, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Residual NADPH oxidase and survival in chronic granulomatous disease.

S. Holland, W. Alvord, B. Soule, 2010, The New England journal of medicine.

Hepatic abnormalities in patients with chronic granulomatous disease

P. Choyke, S. Holland, J. Hoofnagle, 2007, Hepatology.

Hepatic Abscess in Patients With Chronic Granulomatous Disease

Peter Choyke, John I Gallin, Steven M Holland, 2002, Annals of surgery.

Effects of levamisole on normal and abnormal leukocyte locomotion.

C. Kirkpatrick, J. Gallin, D. Wright, 1977, The Journal of clinical investigation.

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.

J. Casanova, C. Picard, E. Meffre, 2008, Immunity.

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2007, The Journal of experimental medicine.

Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection (Job's) syndrome.

D. Alling, J. Gallin, H. Donabedian, 1982, The New England journal of medicine.

Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency.

Vanessa A Mackley, S. Lockett, J. Orange, 2016, Blood.

Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

Steven M. Holland, John I. Gallin, S. Dorman, 1999, The Journal of experimental medicine.

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

D. Rotrosen, H. Malech, T. Leto, 1990, The Journal of biological chemistry.

Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.

D. Rotrosen, H. Malech, J. Gallin, 1988, Science.

Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.

H. Malech, T. Leto, J. Gallin, 1989, Science.

Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.

D. Rotrosen, H. Malech, T. Leto, 1992, Current opinion in immunology.

Monocytes accumulate on Rebuck skin window coverslips but not in skin chamber fluid. A comparative evaluation of two in vivo migration models.

W. Zimmerli, J. Gallin, 1987, Journal of immunological methods.

Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency.

Vanessa A Mackley, S. Lockett, J. Orange, 2016, Blood.

Hematologically important mutations: X-linked chronic granulomatous disease (fourth update).

J. L. Shephard, H. Kanegane, S. Holland, 2021, Blood cells, molecules & diseases.

Minor errors in two published sequences.

H. Malech, T. Leto, J. Gallin, 1989, Science.

Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.

J. Metcalf, B. Seligmann, J. O’Shea, 1985, Journal of immunology.

Anesthetic considerations in patients with chronic granulomatons disease

H. Pass, H. Malech, R. T. Wall, 1990 .

Biochemistry of phagocyte chemotaxis.

J. Gallin, E. Schiffmann, Elliott Schiffmann, 1979, Current topics in cellular regulation.

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.

S. Holland, D. Kuhns, C. Dunbar, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Evaluation of the Patient with Suspected Immunodeficiency

S. Holland, J. Gallin, 2015 .

Mutational analysis of patients with p47-phox-deficient chronic granulomatous disease: The significance of recombination events between the p47-phox gene (NCF1) and its highly homologous pseudogenes.

S. Chanock, S. Holland, T. Lehrnbecher, 2001, Experimental hematology.

The molecular biology of selected phagocyte defects.

J. Gallin, H. Malech, K. Lomax, 1989, Blood reviews.

Inhibition of neutrophil Fc receptor function by cotricosteroids.

M. Klempner, J. Gallin, 1978, Clinical and experimental immunology.

Pretreatment of filtration leukapheresis donors with colchicine.

A. Deisseroth, R. Ungerleider, J. Gallin, 1978, Blood.

Leukocyte transfusions in chronic granulomatous disease: persistence of transfused leukocytes in sputum.

E. Buescher, J. Gallin, 1982, The New England journal of medicine.

Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways.

M. Frank, R. Clark, J. Gallin, 1975, Clinical immunology and immunopathology.

Neutrophil chemoattractant fMet-Leu-Phe receptor expression and ionic events following activation.

B. Seligmann, J. Gallin, 1984, Contemporary topics in immunobiology.

Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease.

R. Blaese, H. Malech, T. Leto, 1992, Blood.

Ionic requirements and subcellular localization of tubulin tyrosinolation in human polymorphonuclear leukocytes.

J. Gallin, J. Nath, 1986, Journal of immunology.

Outcomes From the NIH Clinical Research Training Program: A Mentored Research Experience to Enhance Career Development of Clinician–Scientists

F. Ognibene, M. Gottesman, B. Baum, 2016, Academic medicine : journal of the Association of American Medical Colleges.

Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis

S. Holland, C. Van Waes, C. Waes, 2018, Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.

Thoracic Surgery in Chronic Granulomatous Disease: a 25-Year Single-Institution Experience

S. Steinberg, S. Holland, D. Schrump, 2016, Journal of Clinical Immunology.

Spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation.

D. Wyler, J. Gallin, 1977, Journal of immunology.

Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl.

S. Dreskin, J. Gallin, J. I. Gallin, 1987, The Journal of allergy and clinical immunology.

Elevated urinary histamine in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome: association with eczematoid dermatitis and not with infection.

M. Kaliner, S. Dreskin, J. Gallin, 1987, The Journal of allergy and clinical immunology.

An immune-based biomarker signature is associated with mortality in COVID-19 patients

L. Notarangelo, K. Dobbs, J. Tsang, 2020, JCI insight.

The effect of hemodialysis and C5a des arg on neutrophil subpopulations.

Klempner, J. Balow, J. Gallin, 1980, Blood.

Inherited p40phox deficiency differs from classic chronic granulomatous disease

J. Casanova, S. Vermeire, D. Foell, 2018, The Journal of clinical investigation.

Staining of Eosinophils with Nitroblue Tetrazolium in Patients with Chronic Granulomatous Disease

J. Gallin, Y. Ohno, R. Roberts, 1986, Pediatric Research.

Radioassay of granulocyte chemotaxis. Studies of human granulocytes and chemotactic factors.

J. Gallin, 1974, Antibiotics and Chemotherapy.

Chemotactic disorders.

J. Gallin, C. C. Brown, 1988, Hematology/Oncology Clinics of North America.

Gastrointestinal Histopathology in Chronic Granulomatous Disease: A Study of 87 Patients

S. Holland, H. Malech, M. Miettinen, 2013, The American journal of surgical pathology.

Visceral botryomycosis caused by Neisseria mucosa in a patient with chronic granulomatous disease.

A. Macher, C. Bryan, J. Gallin, 1985, The Journal of infectious diseases.

Intravenous endotoxin recruits a distinct subset of human neutrophils, defined by monoclonal antibody 31D8, from bone marrow to the peripheral circulation.

J. Gallin, H. Malech, C. C. Brown, 1989, Cellular immunology.

Use of an X-linked human neutrophil marker to estimate timing of lyonization and size of the dividing stem cell pool.

D. Alling, E. Buescher, J I Gallin, 1985, The Journal of clinical investigation.

Human neutrophil heterogeneity exists, but is it meaningful?

J. Gallin, 1984, Blood.

Interferon- in the Management of Infectious Diseases

S. Holland, T. Nutman, J. Farber, 1995, Annals of Internal Medicine.

Surgical management of pulmonary infections in chronic granulomatous disease of childhood.

C. Moskaluk, W. Travis, H. Pass, 1993, The Annals of thoracic surgery.

Managing the Interface Between Medical Schools, Hospitals, and Clinical Research

H. Smits, J. Gallin, 1998 .

B-cell activating factor (BAFF) is elevated in chronic granulomatous disease.

S. Holland, T. Fleisher, D. Kuhns, 2013, Clinical immunology.

Treatment with intralesional granulocyte instillations and interferon-gamma for a patient with chronic granulomatous disease and multiple hepatic abscesses.

S. Holland, A. Baker, S. Leitman, 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

NIH conference. Recent advances in chronic granulomatous disease.

B. Seligmann, P. Katz, E. Buescher, 1983, Annals of internal medicine.

Dominantly transmitted hematologic dysfunction clinically similar to fanconi's anemia

P. Levine, A. Auerbach, M. Rick, 1989, American journal of hematology.

An antibody binding to human neutrophils demonstrates antigenic heterogeneity detected early in myeloid maturation which correlates with functional heterogeneity of mature neutrophils.

B. Seligmann, J. Gallin, D. Melnick, 1985, Journal of immunology.

Evidence for oxidative phosphorylation in Streptococcusfaecalis

J. Gallin, P. Vandemark, 1964 .

Stature and weight in chronic granulomatous disease.

E. Buescher, J. Gallin, 1984, The Journal of pediatrics.

Abnormal rabbit heterophil chemotaxis following thermal injury. An in vivo model of an abnormality of the chemoattractant receptor for f-met-leu-phe.

J. Davis, J. Gallin, 1988, Archives of surgery.

Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans.

W. Alvord, D. Kuhns, J. Gallin, 1995, The Journal of infectious diseases.

Leukocyte chemotaxis : methods, physiology, and clinical implications

P. Quie, J. Gallin, 1978 .

A Brief Historical Perspective of Cancer Rehabilitation and Contributions From the National Institutes of Health

L. Chan, L. Gerber, J. Gallin, 2017, PM & R : the journal of injury, function, and rehabilitation.

Contemporary Issues in Cancer Rehabilitation

L. Chan, L. Gerber, J. Gallin, 2017 .

The NIH Clinical Center and the future of clinical research

J. Gallin, 2011, Nature Medicine.

CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease.

H. Malech, N. Whiting-Theobald, G. Linton, 1994, Blood.

NCF1 (p47phox)-deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis.

S. Holland, A. Hsu, D. Kuhns, 2019, Blood advances.

NCF1 (p47 phox ) – de ﬁ cient chronic granulomatous disease: comprehensive genetic and ﬂ ow cytometric analysis

S. Holland, A. Hsu, D. Kuhns, 2019 .

Analphoid marker chromosome in a patient with hyper-IgE syndrome, autism, and mild mental retardation

A. Dutra, S. Holland, J. Puck, 1999, Genetics in Medicine.

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

A. Simeonov, D. McGavern, Cayce E. Dorrier, 2023, Redox biology.

Gastrointestinal Computed Tomography Findings in Chronic Granulomatous Disease with Subgroup Clinicopathologic Analysis

S. Holland, A. Venkatesan, C. Zerbe, 2021, Digestive Diseases and Sciences.

Twenty-Year Follow-Up of Esophageal Involvement in Chronic Granulomatous Disease

S. Holland, T. Heller, J. Gallin, 2009, The American Journal of Gastroenterology.

Phagocyte defects.

J. Gallin, C. J. White, 1986, Clinical Immunology and Immunopathology.

Basic science: Bedrock of progress.

Christopher P Austin, Andrea Norris, William T Riley, 2016, Science.

Immune therapy and potential for gene therapy in chronic granulomatous disease of childhood

J. Gallin, 1992 .

Absence of the Largest Platelet-von Willebrand Multimers in a Patient with Lactoferrin Deficiency and a Bleeding Tendency

J. Gallin, L. McKeown, H. Gralnick, 1992, Thrombosis and Haemostasis.

Neutrophil-speciﬁc Granule Deﬁciency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein (cid:101)

S. Dorman, J. Gallin, S. Holland, 1999 .

John I. Gallin, MD, Director, NIH Clinical Center

J. Gallin, 2007, Journal of Investigative Medicine.

Binding of immunoglobulin- and complement-coated erythrocytes to human neutrophil subpopulations

M. Frank, J. Gallin, Steven C. Whited, 1981, Inflammation.

Editorial: CD8 T cells cut back on calcium intake in the lungs

R. Snyderman, J. Gallin, 2010 .

A neutrophil membrane marker reveals two groups of chronic myelogenous leukemia and its absence may be a marker of disease progression.

J. Metcalf, B. Seligmann, J. Gallin, 1986, Blood.

Endotoxin and lipids.

J. Gallin, D. Kaye, W. O'Leary, 1972, Annals of internal medicine.

A novel post-translational incorporation of tyrosine into multiple proteins in activated human neutrophils. Correlation with phagocytosis and activation of the NADPH oxidase-mediated respiratory burst.

J. Gallin, Y. Ohno, J. Nath, 1992, Journal of immunology.

Serum Concentrations of Lipids in Rabbits Infected with Escherichia Coli and Staphylococcus aureus 1

J. Gallin, D. Kaye, W. O'Leary, 1970, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas

M. Gilbert, T. Mendoza, Ying Yuan, 2021, Clinical Cancer Research.

Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome.

J. Bennett, A. Macher, J. Gallin, 1984, Gastroenterology.

Chapter 1 – A Historical Perspective on Clinical Research

J. Gallin, 2002 .

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

Douglas R. McDonald, A. Al-ghonaium, Sami Al-Hajjar, 2010 .

Impairment of neutrophil bactericidal capacity in patients with AIDS.

A. Fauci, H. Lane, P. Murphy, 1988, The Journal of infectious diseases.

Samter's Immunologic Diseases

J. Schroeder, S. Holland, K. Austen, 2001 .