I. Fox

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Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase.

B. Mitchell, R. Wortmann, N. Edwards, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Degradation of Purine Nucleotides

I. Fox, 2020, Plant Nucleotide Metabolism ‐ Biosynthesis, Degradation, and Alkaloid Formation.

Cloning and expression of human deoxycytidine kinase cDNA.

B. Mitchell, D. Gribbin, D. Ginsburg, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Purine catabolism in man: characterization of placental microsomal 5'-nucleotidase.

I. Fox, P. Marchant, 1976, Canadian journal of biochemistry.

Hyperuricemia in acute illness: a poor prognostic sign.

J. Woolliscroft, I. Fox, H. Colfer, 1982, The American journal of medicine.

Metabolic basis for disorders of purine nucleotide degradation.

I. Fox, Irving H. Fox, 1981, Metabolism: clinical and experimental.

Increased body fluid purine levels during hypotensive events. Evidence for ATP degradation.

J. Woolliscroft, I. Fox, James O. Woolliscroft, 1986, The American journal of medicine.

ATP degradation products after ischemic exercise

V. Shively, T. Bertorini, B. Taylor, 1985, Neurology.

Hyperuricemia: a marker for cell energy crisis.

T. Palella, W. N. Kelley, I. Fox, 1987, The New England journal of medicine.

Partial separation of platelet and placental adenosine receptors from adenosine A2-like binding protein.

S. Zołnierowicz, I. Fox, K. Hutchison, 1990, Molecular pharmacology.

Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover.

I. Fox, J. Faller, 1982, The New England journal of medicine.

Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.

B. Mitchell, T. Gribbin, M. Datta, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for an adenosine receptor in human tissues.

I. Fox, L. Kurpis, D. John, 1984, Advances in experimental medicine and biology.

Soluble and membrane-associated human low-affinity adenosine binding protein (adenotin): properties and homology with mammalian and avian stress proteins.

I. Fox, K. Hutchison, B. Nevins, 1990, Biochemistry.

Purine metabolism during strenuous muscular exercise in man

J. Sutton, I. Fox, C. J. Toews, 1980 .

Purine metabolism during strenuous muscular exercise in man.

J. Sutton, I. Fox, C. J. Toews, 1976, Metabolism: clinical and experimental.

Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy.

I. Fox, H. Stein, A. Hasan, 1976, Annals of internal medicine.

Renal excretion of uric acid during prolonged fasting.

M. Halperin, I. Fox, M. Goldstein, 1976, Metabolism: clinical and experimental.

Hypoxanthine-guanine phosphoribosyltransferase. Characterization of a mutant in a patient with gout.

S. Ōmura, I. Dwosh, I. Fox, 1975, The Journal of clinical investigation.

Pharmacologic effects of nicotinic acid on human purine metabolism.

I. Fox, S. Gershon, 1974, The Journal of laboratory and clinical medicine.

Hyperuricemia and hypertriglyceridemia: metabolic basis for the association.

E. Marliss, I. Dwosh, I. Fox, 1985, Metabolism: clinical and experimental.

Adenosine triphosphate degradation in specific disease.

I. Fox, 1985, The Journal of laboratory and clinical medicine.

Characteristics of an adenosine A1 binding site in human placental membranes.

I. Fox, K. Hutchison, R. F. Bruns, 1989, Archives of biochemistry and biophysics.

Mechanism for the paradoxical aciduria following alkali administration to prolonged-fasted patients.

M. Halperin, E. Marliss, I. Fox, 1975, Metabolism: clinical and experimental.

Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate.

J. Puig, I. Fox, 1984, The Journal of clinical investigation.

Brain benzodiazepine receptor binding and purine concentration in Lesch-Nyhan syndrome

S. Kish, O. Hornykiewicz, B. Kapur, 1985, Brain Research.

Characteristics of high-affinity and low-affinity adenosine binding sites in human cerebral cortex.

I. Fox, D. John, 1985, The Journal of laboratory and clinical medicine.

beta-Hydroxybutyrate decreases adenosine triphosphate degradation products in human subjects.

S. Schmaltz, I. Fox, J. Spychała, 1994, The Journal of laboratory and clinical medicine.

Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia.

J. Cassidy, N. Edwards, I. Fox, 1978, Science.

Hypoxanthine-guanine phosphoribosyltransferase: Mosaicism in the peripheral erythrocytes of a heterozygote for a normal and a mutant enzyme

I. Fox, P. Marchant, S. Lacroix, 1976, Biochemical Genetics.

The pharmacology of hypouricemic effect of benzbromarone.

I. Fox, D. S. Sinclair, 1975, The Journal of rheumatology.

Altered properties of human T-lymphoblast soluble low Km 5'-nucleotidase: comparison with B-lymphoblast enzyme.

P. Nowak, V. Madrid-Marina, I. Fox, 1993, Leukemia research.

Regulation of purine metabolism by plasma membrane and cytoplasmic 5'-nucleotidases.

N. Edwards, I. Fox, D. Recker, 1982, The American journal of physiology.

Familial hypogammaglobulinemia with variable serum immunoglobulins. Concordance with lymphocyte ecto-5'-nucleotidase deficiency.

H. Sampson, K. Rich, I. Fox, 1981, American journal of diseases of children.

Lymphocyte 5'-nucleotidase deficiency in hypogammaglobulinemia: clinical characteristics.

J. Cassidy, N. Edwards, I. Fox, 1980, Clinical immunology and immunopathology.

Purine Nucleoside Phosphorylase Deficiency

E. Gelfand, R. Wortmann, J. Kaminska, 1979 .

Lymphocyte 5'-nucleotidase deficiency: clinical and metabolic characteristics of the associated hypogammaglobulinemia.

J. Cassidy, N. Edwards, I. Fox, 1979, Advances in experimental medicine and biology.

Purine nucleoside phosphorylase deficiency: altered kinetic properties of a mutant enzyme.

E. Gelfand, D. Biggar, I. Fox, 1977, Science.

Distribution of 5'-nucleotidase in human lymphoid tissues.

E. Gelfand, H. Dosch, N. Edwards, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Hereditary xanthinuria. Evidence for enhanced hypoxanthine salvage.

J. Puig, I. Fox, F. Mateos, 1987, The Journal of clinical investigation.

Effect of fructose infusion in hereditary xanthinuria.

J. Puig, I. Fox, F. Mateos, 1986, Advances in experimental medicine and biology.

Radiologic features of a pyrophosphate-like arthropathy associated with long-term dialysis

R. Swartz, E. Braunstein, W. Martel, 2004, Skeletal Radiology.

Familial hyperuricemia and renal disease.

C. Hsu, P. Gikas, I. Fox, 1980, Archives of internal medicine.

Effects of orotic acid on purine and lipoprotein metabolism in man.

R. Levy, J. Seegmiller, W. N. Kelley, 1970, Metabolism: clinical and experimental.

Purine Metabolism in Friedreich's Ataxia

D. Shapcott, I. Fox, B. Lemieux, 1978, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Purification and characterization of the adenosine A2-like binding site from human placental membrane.

I. Fox, K. Hutchison, 1989, The Journal of biological chemistry.

Human T-lymphoblast deoxycytidine kinase: purification and properties.

B. Mitchell, D. Shewach, I. Fox, 1989, Biochemistry.

Inhibition of mitogen mediated lymphocyte blastogenesis by adenosine.

E. Keystone, I. Fox, D. Gladman, 1975, Immunological communications.

Adenosine triphosphate turnover in humans. Decreased degradation during relative hyperphosphatemia.

S. Schmaltz, I. Fox, M. Johnson, 1989, The Journal of clinical investigation.

Decreased Degradation during Relative Hyperphosphatemia

S. Schmaltz, I. Fox, K. Tekkanat, 1989 .

Adenosine metabolism: modification by S-adenosylhomocysteine and 5'-methylthioadenosine.

C. Herring, T. Palella, I. Fox, 1982, Archives of biochemistry and biophysics.

Binding characteristics of an adenosine receptor in human placenta.

I. Fox, L. Kurpis, 1983, The Journal of biological chemistry.

Cellular immune deficiency with autoimmune hemolytic anemia in purine nucleoside phosphorylase deficiency.

T. Palella, K. Rich, I. Fox, 1979, The American journal of medicine.

Altered purine and pyrimidine metabolism in erythrocytes with purine nucleoside phosphorylase deficiency

E. Gelfand, N. Edwards, K. Rich, 1980, Biochemical Genetics.

Purine nucleoside phosphorylase deficiency: improved metabolic and immunologic function with erythrocyte transfusions.

K. Rich, I. Fox, E. Majias, 1980, The New England journal of medicine.

Partial deficiency of purine nucleoside phosphorylase: studies of purine and pyrimidine metabolism.

E. Gelfand, D. Biggar, N. Edwards, 1978, The Journal of laboratory and clinical medicine.

Partial purine nucleoside phosphorylase deficiency. Studies of lymphocyte function.

E. Gelfand, H. Dosch, I. Fox, 1978, The Journal of clinical investigation.

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.

T. Merigan, S. Sacks, I. Fox, 1982, The Journal of clinical investigation.

Phosphoribosylpyrophosphate in man: biochemical and clinical significance.

W. N. Kelley, I. Fox, W. Kelley, 1971, Annals of internal medicine.

Evidence for adenosine triphosphate degradation in critically-ill patients.

R. Simon, D. Dantzker, C. Grum, 1985, Chest.

Inhibition of phosphoribosylpyrophosphate synthesis by purine nucleosides in human erythrocytes.

I. Fox, G. Planet, 1976, The Journal of biological chemistry.

Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition.

W N Kelley, I H Fox, W. N. Kelley, 1972, The Journal of biological chemistry.

The role of adenosine and 2'-deoxyadenosine in mammalian cells.

W N Kelley, I H Fox, W. N. Kelley, 1978, Annual review of biochemistry.

PARTIAL DEFICIENCY OF ADENINE PHOSPHORIBOSYLTRANSFERASE IN MAN

I. Fox, S. Lacroix, M. Moore, 1977, Medicine.

Purine enzyme abnormalities: a four year experience.

I. Fox, 1977, Advances in experimental medicine and biology.

Cyclosporine-induced hyperuricemia and gout.

T. Palella, I. Fox, M. Mcquillan, 1989, The New England journal of medicine.

Inhibition of guinea-pig oxyntic cell function by adenosine and prostaglandins.

A. Vinik, I. Fox, A. Heldsinger, 1986, The Journal of pharmacology and experimental therapeutics.

Metabolic alterations in burn patients: detection of adenosine triphosphate degradation products and lipid peroxides.

G. Till, J O Woolliscroft, J K Prasad, 1990, Burns : journal of the International Society for Burn Injuries.

Human placental adenosine kinase. Kinetic mechanism and inhibition.

T. Palella, I. Fox, C. Andres, 1980, The Journal of biological chemistry.

S-Adenosylhomocysteine accumulation and selective cytotoxicity in cultured T- and B-lymphocytes.

T. Wilens, T. Palella, I. Fox, 1982, The Journal of laboratory and clinical medicine.

Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.

I. Fox, J. Kamińska, 1980, The Journal of laboratory and clinical medicine.

Duchenne muscular dystrophy

T. Bertorini, R. Shefner, I. Fox, 1985, Neurology.

High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP.

V. Madrid-Marina, I. Fox, J. Spychała, 1988, The Journal of biological chemistry.

Acquired increases of human erythrocyte purine enzymes.

I. Fox, P. Marchant, S. Lacroix, 1976, Metabolism: clinical and experimental.

Adenine nucleotide turnover in hypoxanthine-guanine phosphoribosyl-transferase deficiency: evidence for an increased contribution of purine biosynthesis de novo.

I H Fox, J. Puig, I. Fox, 1989, Metabolism: clinical and experimental.

Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts.

W. N. Kelley, I. Fox, T. Beardmore, 1971, Biochemical pharmacology.

Regulation of purine biosynthesis in cultured human cells. I. Effects of orotic acid.

J. Wyngaarden, W. N. Kelley, I. Fox, 1970, Biochimica et biophysica acta.

Regulation of adenosine kinase by adenosine analogs.

I. Fox, M. Hurley, B. Lin, 1988, Molecular pharmacology.

Measurement of nucleoside kinases in crude tissue extracts.

I. Fox, M. Hurley, 1983, Biochemical Medicine.

Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase.

B. Mitchell, D. Shewach, I. Fox, 1989, The Journal of biological chemistry.

Human placental cytoplasmic 5'-nucleotidase. Kinetic properties and inhibition.

V. Madrid-Marina, I. Fox, 1986, The Journal of biological chemistry.

Clinical Expression of Blocks of Purine Nucleotide Degradation

I. Fox, 1983 .

Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties.

W N Kelley, I H Fox, W. N. Kelley, 1971, The Journal of biological chemistry.

Depletion of erythrocyte phosphoribosylpyrophosphate in man.

J. Wyngaarden, W. N. Kelley, I. Fox, 1970, The New England journal of medicine.

Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.

I. Fox, M. Hurley, B. Lin, 1985, Advances in experimental medicine and biology.

Isocratic separation of ATP and its degradation products from biological fluids by automated liquid chromatography.

I. Fox, K. Tekkanat, 1988, Clinical chemistry.

Studies on the mechanism of fructose-induced hyperuricemia in man.

W. N. Kelley, I. Fox, W. Kelley, 1972, Metabolism: clinical and experimental.

Pyrimidine nucleotide biosynthesis. A study of normal and purine enzyme-deficient cells.

I. Fox, L. Burk, J. Kamińska, 1978, The Journal of biological chemistry.

Human placental cytoplasmic 5'-nucleotidase: kinetics and molecular properties.

V. Madrid-Marina, I. Fox, J. Kamińska, 1986, Advances in experimental medicine and biology.

Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase.

B. Mitchell, D. Shewach, I. Fox, 1989, Advances in experimental medicine and biology.

Purification and properties of human placental adenosine kinase.

I. Fox, C. Andres, 1979, The Journal of biological chemistry.

Cyclosporine-induced hyperuricemia and gout.

T. Palella, Hsiao-Yi Lin, I. Fox, 1989, The New England journal of medicine.

Hyperuricemia and gout in cyclosporin A-treated renal transplant recipients.

T. Palella, I. Fox, L. Rocher, 1989, Advances in Experimental Medicine and Biology.

Management of gout.

W. N. Kelley, I. Fox, Schumacher Hr, 1979, JAMA.

Enhanced purine salvage during allopurinol therapy: an important pharmacologic property in humans.

N. Edwards, I. Fox, D. Recker, 1981, The Journal of laboratory and clinical medicine.

Increased Adenine Nucleotide Turnover in Duchenne Muscular Dystrophy

T. Bertorini, N. Edwards, I. Fox, 1981, Pediatric Research.

Adenine phosphoribosyltransferase deficiency in man. Report of a second family.

I. Fox, W. Kelley, J. Meade, 1973, The American journal of medicine.

Normal B-lymphocyte function in patients with Lesch-Nyhan syndrome and HGPRT deficiency.

E. Gelfand, H. Dosch, I. Fox, 1978, Clinical and experimental immunology.

Overproduction of uric acid in hypoxanthine-guanine phosphoribosyltransferase deficiency. Contribution by impaired purine salvage.

N. Edwards, I H Fox, I. Fox, 1979, The Journal of clinical investigation.

Partial Purine Nucleoside Phosphorylase Deficiency STUDIES

H. Dosch, I. Fox, W. Biggar, 2013 .

Hyperuricemia in glycogen storage disease type I. Contributions by hypoglycemia and hyperglucagonemia to increased urate production.

A. Vinik, I. Fox, J. Faller, 1985, The Journal of clinical investigation.

Duchenne muscular dystrophy: normal ATP turnover in cultured cells.

T. Bertorini, R. Shefner, I. Fox, 1985, Neurology.

Evidence for "low Km" and "high Km" soluble 5'-nucleotidases in human tissues and rat liver.

V. Madrid-Marina, I. Fox, J. Spychała, 1989, Advances in experimental medicine and biology.

Ethanol induced alterations of uric acid metabolism.

I. Fox, J. Faller, 1984, Advances in experimental medicine and biology.

Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome.

K. Shannak, O. Hornykiewicz, K. Lloyd, 1981, The New England journal of medicine.

Purification and properties of human cytoplasmic 5'-nucleotidase

V. Madrid-Marina, I. Fox, J. Berry, 1986 .

Chronic allopurinol and adenine therapy in Duchenne muscular dystrophy

J. Griffin, C. Chesney, T. Bertorini, 1985, Neurology.

Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.

I. Fox, M. Hurley, B. Lin, 1985, The Journal of biological chemistry.

Human Placental Nucleoside Kinase Activities a

I. Fox, M. Hurley, IRVING H. FOX, 1985, Annals of the New York Academy of Sciences.

Inborn errors of purine and pyrimidine metabolism.

I. Fox, 1976, Clinics of Perinatology.

Purine catabolism in man: inhibition of 5'-phosphomonesterase activities from placental microsomes.

I. Fox, P. Marchant, 1976, Canadian journal of biochemistry.

ALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTURE

J. Meade, I. Fox, T. Beardmore, 1971, Annals of the New York Academy of Sciences.

Enzyme replacement in the Lesch-Nyhan syndrome with long-term erythrocyte transfusions.

N. Edwards, I. Fox, W. Jeryc, 1984, Advances in experimental medicine and biology.

Hypoxanthine salvage in man: its importance in urate overproduction in the Lesch-Nyhan syndrome.

N. Edwards, I. Fox, D. Recker, 1980, Advances in experimental medicine and biology.

Studies on the mechanism of fructose-induced hyperuricemia in man.

I. Fox, W. Kelley, 1974, Advances in experimental medicine and biology.

Human hypoxanthine-guanine phosphoribosyltransferase.

W N Kelley, J. Wilson, J M Wilson, 1983, The Journal of biological chemistry.

Properties of adenotin reconstituted into phospholipid vesicles.

I. Fox, K. Hutchison, M. Prasad, 1991, The American journal of the medical sciences.

Effect of allopurinol on pyrimidine metabolism in the Lesch-Nyhan syndrome.

I. Fox, T. Beardmore, W. Kelley, 1970, The Lancet.

Purine Ribonucleotide Catabolism: Clinical and Biochemical Significance

I. Fox, 1974 .

Purine nucleoside phosphorylase deficiency: biochemical properties and heterogeneity in two families.

E. Gelfand, R. Wortmann, K. Rich, 1979, Arthritis and rheumatism.

Purine nucleoside phosphorylase: the normal enzyme and structural alterations in immunodeficiency disease.

R. Wortmann, I. Fox, C. Andres, 1978, Ciba Foundation symposium.

AMP and IMP dephosphorylation by soluble high- and low-Km 5'-nucleotidases.

P. Nowak, V. Madrid-Marina, I. Fox, 1989, The American journal of physiology.

Deferoxamine induced decreases of lipid peroxides in rheumatoid arthritis.

G. Till, I. Fox, E. Fudman, 1987, The Journal of rheumatology.

Normal levels of 5'-nucleotidase activity in lymphocytes from patients with x-linked agammaglobulinemia.

N. Edwards, I. Fox, 1979, Science.

The application of affinity chromatography for the separation of "high Km" and "low Km" 5'-nucleotidase and other AMP metabolizing enzymes.

I. Fox, J. Spychała, 1989, Advances in experimental medicine and biology.

Uric-acid lithiasis in an infant with cyanotic congenital heart disease.

I. Fox, T. Izukawa, S. Kooh, 1977, The Journal of pediatrics.

Electrophoretic variation in partial deficiencies of hypoxanthine-guanine phosphoribosyltransferase.

I. Fox, S. Lacroix, 1977, Advances in experimental medicine and biology.

Plasma membrane 5'-nucleotidase and other purine enzymes in murine lymphocytes.

B. Mitchell, N. Edwards, I. Fox, 1984, Advances in experimental medicine and biology.

Altered cell cycle distributions of cultured human lymphoblasts during cytotoxicity related to adenosine deaminase inhibition.

P. Dean, T. Palella, I. Fox, 1984, Metabolism: clinical and experimental.

CHARACTERISTICS OF HIGH AFFINITY AND LOW AFFINITY ADENOSINE BINDING SITES IN HUMAN CEREBRAL CORTEX: 96

I. Fox, D. John, 1985, Pediatric Research.

Alterations of human purine metabolism in megaloblastic anemia.

I. Fox, P. Marchant, D. Dotten, 1977, Advances in experimental medicine and biology.

Limited value of uric acid to creatinine ratios in estimating uric acid excretion.

R. Wortmann, I. Fox, 1980, Annals of internal medicine.