C. Swearingen

发表

Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture

K. Thirunavukkarasu, J. Haller, T. Higgins, 2015, Clinical orthopaedics and related research.

A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.

K. Thirunavukkarasu, D. Mudra, M. Chambers, 2017, Journal of medicinal chemistry.

Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity.

M. Hodsdon, N. Bivi, R. Siegel, 2020, Journal of immunological methods.

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

K. Duffin, S. Chandrasekhar, K. Thirunavukkarasu, 2010, Osteoarthritis and cartilage.

Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.

B. Norman, K. Thirunavukkarasu, H. Bui, 2017, Osteoarthritis and cartilage.

Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.

K. Thirunavukkarasu, V. Klimkowski, M. Chambers, 2014, Journal of medicinal chemistry.

MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.

G. Decrescenzo, J. McDonald, C. Swearingen, 2010, Bioorganic & medicinal chemistry letters.

Development and characterization of a novel ELISA based assay for the quantitation of sub-nanomolar levels of neoepitope exposed NITEGE-containing aggrecan fragments.

K. Duffin, K. Thirunavukkarasu, M. Chambers, 2007, Journal of immunological methods.

Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.

K. Thirunavukkarasu, D. Mudra, M. Chambers, 2016, Journal of medicinal chemistry.

Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine.

K. Duffin, K. Thirunavukkarasu, C. Swearingen, 2010, Osteoarthritis and cartilage.

α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1

G. Decrescenzo, P. Mehta, C. Swearingen, 2001 .

alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.

G. Decrescenzo, P. Mehta, C. Swearingen, 2001, Bioorganic & medicinal chemistry letters.

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk

R. Higgs, M. Hodsdon, T. Moore, 2019, mAbs.

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

C. Carron, G. Decrescenzo, P. Mehta, 2005 .

Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401.

R. Karr, D. Kirschmann, T. Baudino, 1995, Arthritis and rheumatism.

Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide

A. Sette, R. Karr, F. Sinigaglia, 1995, The Journal of experimental medicine.

Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis

B. Norman, K. Thirunavukkarasu, Spencer B. Jones, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Ying Yu, Gary A Decrescenzo, James R Kiefer, 2010, Journal of medicinal chemistry.

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

B. Norman, S. Chandrasekhar, K. Thirunavukkarasu, 2016, ACS medicinal chemistry letters.

Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates.

G. Decrescenzo, J. McDonald, T. Boehm, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

C. Carron, G. Decrescenzo, P. Mehta, 2005 .

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

K. Thirunavukkarasu, C. Swearingen, C. J. Rito, 2010, Osteoarthritis and cartilage.