J. Bowen

A. Stringer, J. Bowen, R. Logan, 2015, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

C. Estilo, S. Elad, R. Lalla, 2012, Supportive Care in Cancer.

Contribution of TLR4 to colorectal tumor microenvironment, etiology and prognosis

J. Bowen, J. Coller, H. Wardill, 2022, Journal of Cancer Research and Clinical Oncology.

Cytotoxic Effects of the Dual ErbB Tyrosine Kinase Inhibitor, Lapatinib, on Walker 256 Rat Breast Tumour and IEC-6 Rat Normal Small Intestinal Cell Lines

J. Bowen, D. Keefe, E. Bateman, 2019, Biomedicines.

Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity

C. Prestidge, J. Bowen, J. Coller, 2022, Cancer Chemotherapy and Pharmacology.

Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation

C. Prestidge, J. Bowen, J. Coller, 2022, Inflammation.

Emerging drugs for chemotherapy-induced mucositis

S. Sonis, J. Bowen, D. Keefe, 2008 .

Structural insight and analysis of TLR4 interactions with IAXO-102, TAK-242 and SN-38: an in silico approach

C. Prestidge, J. Bowen, J. Coller, 2022, In Silico Pharmacology.

Chemotherapy-induced mucosal barrier dysfunction: an updated review on the role of intestinal tight junctions

J. Bowen, H. Wardill, 2013, Current opinion in supportive and palliative care.

Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats

A. Stringer, J. Bowen, R. Logan, 2007, Cancer biology & therapy.

VSL#3 probiotic treatment reduces chemotherapy-induced diarrhoea and weight loss

A. Stringer, J. Bowen, R. Gibson, 2007, Cancer biology & therapy.

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines.

S. Elad, P. Bossi, R. Lalla, 2019, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.

New pharmacotherapy options for chemotherapy-induced alimentary mucositis

J. Bowen, R. Gibson, H. Wardill, 2014, Expert opinion on biological therapy.

The pathogenesis of mucositis: updated perspectives and emerging targets.

A. Kandwal, S. Sonis, S. Elad, 2019, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.

Editorial Comment: Does gut-derived inflammation enhance pain signaling following chemotherapy in a Toll-like receptor 4-dependent manner?

J. Bowen, R. Gibson, H. Wardill, 2015, Current opinion in supportive and palliative care.

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

D. McGuire, L. Elting, S. Sonis, 2014, Cancer.

Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs.

S. Sonis, A. Stringer, J. Bowen, 2008, Cancer Biology & Therapy.

Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis

S. Sonis, A. Stringer, J. Bowen, 2008, Cancer Chemotherapy and Pharmacology.

Systematic review of basic oral care for the management of oral mucositis in cancer patients

D. McGuire, F. Gibson, S. Elad, 2013, Supportive Care in Cancer.

Emerging evidence on the pathobiology of mucositis

S. Sonis, S. Elad, R. Lalla, 2013, Supportive Care in Cancer.

Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study

J. Finnie, N. Al-Dasooqi, J. Bowen, 2017, Supportive Care in Cancer.

Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?

N. Al-Dasooqi, J. Bowen, R. Gibson, 2009, Cancer Chemotherapy and Pharmacology.

Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis

A. Stringer, J. Bowen, R. Gibson, 2012, Chemotherapy research and practice.

Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

J. Bowen, A. Yool, Pak Hin Chow, 2020, Cancers.

Emerging evidence on the pathobiology of mucositis

S. Sonis, S. Elad, R. Lalla, 2013, Supportive Care in Cancer.

Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses

Jared M. Campbell, M. Peters, M. Stephenson, 2016, Cancer Chemotherapy and Pharmacology.

The application of cytokeratin-18 as a biomarker for drug-induced liver injury

C. Goldring, R. Jenkins, Neil S French, 2021, Archives of Toxicology.

Prevention of oral mucositis in head and neck cancer patients : a systematic review.

J. Bowen, 2012 .

HER2 Targeted Therapy‐Induced Gastrointestinal Toxicity: From the Clinical Experience to Possible Molecular Mechanisms

N. Al-Dasooqi, J. Bowen, R. Gibson, 2012 .

Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport.

C. Prestidge, C. Porter, N. Trevaskis, 2021, Journal of controlled release : official journal of the Controlled Release Society.

TLR4 mediates Il-6 production in irinotecan-induced mucositis

J. Bowen, H. Wardill, S. Khan, 2019, bioRxiv.

TLR4/PKC‐mediated tight junction modulation: A clinical marker of chemotherapy‐induced gut toxicity?

Hannah R Wardill, Rachel J Gibson, Richard M Logan, 2014, International journal of cancer.

Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats

A. Stringer, J. Bowen, R. Logan, 2008, Cancer biology & therapy.

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

A. Cummins, J. Bowen, R. Gibson, 2006, Supportive Care in Cancer.

Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

K. Chiam, D. Watson, D. Hussey, 2020, World journal of gastroenterology.

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis.

J. Bowen, R. Gibson, H. Wardill, 2015, Cancer treatment reviews.

Mechanisms of TKI-induced diarrhea in cancer patients

J. Bowen, 2013, Current opinion in supportive and palliative care.

Irinotecan‐induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat

A. Stringer, N. Al-Dasooqi, J. Bowen, 2011, International journal of experimental pathology.

Role of p53 in irinotecan-induced intestinal cell death and mucosal damage

A. Prabowo, A. Cummins, A. Stringer, 2007, Anti-cancer drugs.

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

George C. Mayne, David I. Watson, Damian J. Hussey, 2015, Journal of Gastrointestinal Surgery.

Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment

J. Bowen, R. Gibson, J. Coller, 2021, Cancer Chemotherapy and Pharmacology.

Dacomitinib‐induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats

J. Finnie, J. Bowen, R. Gibson, 2017, International journal of cancer.

Chemotherapy-induced gut toxicity and pain: involvement of TLRs

M. Hutchinson, J. Bowen, R. Gibson, 2016, Supportive Care in Cancer.

Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis

J. Bowen, R. Logan, R. Gibson, 2018, Supportive Care in Cancer.

Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer

J. Bowen, R. Gibson, H. Wardill, 2016, Current opinion in supportive and palliative care.

The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity

J. Bowen, R. Gibson, J. Coller, 2018, International journal of cancer.

Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis

A. Stringer, J. Bowen, R. Logan, 2010, Radiation oncology.

Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.

Rachel J Gibson, Joanne M Bowen, A. Stringer, 2009, Current drug metabolism.

Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction

S. Sonis, K. Mander, J. Bowen, 2016, International journal of cancer.

Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis

P. Hughes, D. Dimasi, J. Bowen, 2018, PloS one.

Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability

W. Leifert, J. Bowen, J. Coller, 2021, Inflammatory Intestinal Diseases.

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model

J. Bowen, R. Gibson, Anthony D. Wignall, 2019, Chemotherapy.

Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat

A. Stringer, N. Al-Dasooqi, J. Bowen, 2010, Experimental biology and medicine.

A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-κB, COX-1, and COX-2

A. Stringer, J. Bowen, R. Gibson, 2007, Molecular Cancer Therapeutics.

Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production in chemotherapy-induced mucositis

J. Bowen, H. Wardill, S. Khan, 2018, Cancer Chemotherapy and Pharmacology.

Fluoropyrimidine and platinum toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.

Jared M. Campbell, M. Peters, M. Stephenson, 2016, Pharmacogenomics.

Prevention and treatment of regimen-related mucosal toxicity.

J. Bowen, 2008, Recent patents on anti-cancer drug discovery.

A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options

J. Bowen, R. Logan, R. Gibson, 2016, Experimental biology and medicine.

Dacomitinib‐induced diarrhea: Targeting chloride secretion with crofelemer

J. Bowen, R. Gibson, D. Keefe, 2018, International journal of cancer.

Intestinal accumulation of silica particles in a rat model of dextran sulfate sodium-induced colitis

J. Bowen, R. Gibson, J. Coller, 2019, Annals of gastroenterology.

Chemotherapy-Induced Diarrhea Is Associated with Changes in the Luminal Environment in the DA Rat

A. Stringer, J. Bowen, R. Logan, 2007, Experimental biology and medicine.

Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients

J. Lees, N. Al-Dasooqi, J. Bowen, 2009, Investigational New Drugs.

Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats

Yu-Wen Su, C. Xian, J. Bowen, 2018, Journal of cellular biochemistry.

Nuclear factor κB (NFκB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes

J. Bowen, R. Gibson, A. Yeoh, 2005 .

Selection of Housekeeping Genes for Gene Expression Studies in a Rat Model of Irinotecan-Induced Mucositis

A. Stringer, N. Al-Dasooqi, J. Bowen, 2011, Chemotherapy.

the dark agouti rat Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in

A. Stringer, N. Al-Dasooqi, J. Bowen, 2010 .

Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2.

A. Stringer, J. Bowen, R. Logan, 2006, Cancer treatment reviews.

Cytotoxic chemotherapy upregulates pro‐apoptotic Bax and Bak in the small intestine of rats and humans

A. Cummins, J. Bowen, R. Gibson, 2005, Pathology.

Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes.

J. Bowen, R. Gibson, A. Yeoh, 2005, International journal of radiation oncology, biology, physics.

Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer

M. R. Inglis, A. Cummins, Rachel J Gibson, 2003, Journal of gastroenterology and hepatology.

Toll-like receptor 4 signaling: a common biological mechanism of regimen-related toxicities: an emerging hypothesis for neuropathy and gastrointestinal toxicity.

S. Sonis, K. Mander, J. Bowen, 2015, Cancer treatment reviews.

Complications of Treatment Toll-like receptor 4 signaling : A common biological mechanism of regimen-related toxicities

S. Sonis, K. Mander, J. Bowen, 2015 .

HER2 targeted therapies for cancer and the gastrointestinal tract.

N. Al-Dasooqi, J. Bowen, R. Gibson, 2009, Current drug targets.

Systematic review of agents for the management of gastrointestinal mucositis in cancer patients

S. Elad, R. Lalla, N. Blijlevens, 2012, Supportive Care in Cancer.

Highlight article: Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity

J. Bowen, R. Gibson, H. Wardill, 2019, Experimental biology and medicine.

Establishment of a Single-Dose Irinotecan Model of Gastrointestinal Mucositis

J. Finnie, J. Bowen, R. Gibson, 2007, Chemotherapy.

The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats

C. Pietra, J. Bowen, B. Mayo, 2020, Cancer Chemotherapy and Pharmacology.

Predictive model for risk of severe gastrointestinal toxicity following chemotherapy using patient immune genetics and type of cancer: a pilot study

C. Karapetis, J. Tuke, J. Bowen, 2015, Supportive Care in Cancer.

Erratum: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy (Cancer (2014) 120 (1453-1661))

D. McGuire, L. Elting, S. Sonis, 2015 .

Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy

C. Karapetis, J. Tuke, J. Bowen, 2023, Cancer Chemotherapy and Pharmacology.

TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea

J. Bowen, R. Logan, R. Gibson, 2016, Molecular Cancer Therapeutics.

Development of the Rat Model of Lapatinib-Induced Diarrhoea

Joanne M Bowen, J. Bowen, 2014, Scientifica.

Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?

S. Sonis, A. Stringer, J. Bowen, 2008, Cancer Chemotherapy and Pharmacology.

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

J. Bowen, R. Logan, R. Gibson, 2016, Supportive Care in Cancer.

96. Expression of TLRs in the rat intestine following chemotherapy for cancer

M. Hutchinson, J. Bowen, R. Gibson, 2012, Brain, Behavior, and Immunity.

Investigation of Effect of Nutritional Drink on Chemotherapy-Induced Mucosal Injury and Tumor Growth in an Established Animal Model

E. Schiffrin, A. Stringer, J. Bowen, 2013, Nutrients.

Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity

A. Stringer, N. Al-Dasooqi, J. Bowen, 2017, Supportive Care in Cancer.

Technological advances in mucositis research: new insights and new issues.

J. Bowen, R. Gibson, D. Keefe, 2008, Cancer treatment reviews.

Emerging drugs for chemotherapy-induced mucositis.

S. Sonis, J. Bowen, D. Keefe, 2008, Expert Opinion on Emerging Drugs.

Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy

W. Tissing, H. Harmsen, J. van Bergenhenegouwen, 2023, Cell death & disease.

Chemotherapy-induced mucosal barrier dysfunction: an updated review on the role of intestinal tight junctions

J. Bowen, H. Wardill, 2013, Current opinion in supportive and palliative care.

Contribution of TLR4 to colorectal tumor microenvironment, etiology and prognosis

J. Bowen, J. Coller, H. Wardill, 2022, Journal of Cancer Research and Clinical Oncology.

Use of Project Teams in Preclinical Development

J. Bowen, R. Gibson, D. Keefe, 2010 .

A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-KB, COX-1, and COX-2

A. Stringer, J. Bowen, D. Keefe, 2007 .

Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea

J. Finnie, F. Boyle, A. Stringer, 2012, Cancer biology & therapy.

The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects

J. Bowen, R. Gibson, J. Coller, 2023, Cancers.

Fibre-rich diet attenuates chemotherapy-related neuroinflammation in mice

P. Joyce, J. Bowen, Anthony D. Wignall, 2023, Brain, Behavior, and Immunity.

Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma

D. Watson, D. Hussey, S. Thompson, 2015, Journal of Gastrointestinal Surgery.

What are the predictive factors in the risk and severity of chemotherapy-induced gastrointestinal toxicity?

J. Bowen, R. Gibson, J. Coller, 2015, Future oncology.

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model

J. Bowen, R. Gibson, Anthony D. Wignall, 2019, Chemotherapy.