A. Heyerick

发表

The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine.

W. Verstraete, S. Rabot, T. van de Wiele, 2006, The Journal of nutrition.

Nutrient Physiology , Metabolism , and Nutrient-Nutrient Interactions The Prenylflavonoid Isoxanthohumol from Hops ( Humulus lupulus L . ) Is Activated into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in the Human Intestine 1

T. Wiele, W. Verstraete, S. Rabot, 2006 .

Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer.

S. Milligan, A. Heyerick, D. de Keukeleire, 1999, The Journal of clinical endocrinology and metabolism.

Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin.

S. Milligan, A. Heyerick, D. de Keukeleire, 2002, Reproduction.

The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.

S. Milligan, Xiao Feng Li, K. O’Byrne, 2006, The Journal of endocrinology.

Metabolism of hop-derived bitter acids.

J. Remon, D. Deforce, K. Boussery, 2013, Journal of agricultural and food chemistry.

Heterologous screening of hybridomas for the development of broad-specific monoclonal antibodies against deoxynivalenol and its analogues

D. Deforce, S. Saeger, S. Eremin, 2014 .

Absorption, translocation and metabolism of metamitron in Chenopodium album.

D. Reheul, D. Deforce, Sven Mangelinckx, 2012, Pest management science.

Metabolism of the food-associated carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human intestinal microbiota.

W. Verstraete, T. van de Wiele, N. de Kimpe, 2006, Journal of agricultural and food chemistry.

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

P. Lambin, L. Dubois, A. Jochems, 2021, Molecular Cancer Therapeutics.

Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine.

W. Verstraete, S. Rabot, A. Bruneau, 2008, The Journal of nutrition.

Riboflavin-sensitized photooxidation of isohumulones and derivatives

L. Skibsted, K. Olsen, M. Andersen, 2004, Photochemical and Photobiological Sciences.

A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.

H. Depypere, M. Bracke, A. Heyerick, 2006, Maturitas.

Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serum.

S. Bolca, A. Heyerick, D. de Keukeleire, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women.

W. Verstraete, I. Huybrechts, T. van de Wiele, 2007, The Journal of nutrition.

Quantitation of soy-derived phytoestrogens in human breast tissue and biological fluids by high-performance liquid chromatography.

M. Mareel, H. Depypere, M. Bracke, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Distribution of Soy-Derived Phytoestrogens in Human Breast Tissue and Biological Fluids

H. Depypere, M. Bracke, J. Van der Eycken, 2004, Obstetrics and gynecology.

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin.

W. Verstraete, S. Possemiers, A. Heyerick, 2005, Journal of agricultural and food chemistry.

Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood

H. Depypere, M. Bracke, A. Heyerick, 2008 .

Disposition of hop prenylflavonoids in human breast tissue.

P. Blondeel, H. Depypere, R. V. van Breemen, 2010, Molecular nutrition & food research.

Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women

W. Verstraete, I. Huybrechts, T. van de Wiele, 2007, British Journal of Nutrition.

Feeding soybean meal increases the blood level of isoflavones and reduces the steroidogenic capacity in bovine corpora lutea, without affecting peripheral progesterone concentrations.

P. Bossaert, S. Cools, M. Hostens, 2014, Animal reproduction science.

Quantification of xanthohumol, isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin in hop extracts and derived capsules using secondary standards.

S. Apers, L. Pieters, A. Vlietinck, 2010, Talanta.

Functional properties of hop polyphenols.

S. Milligan, A. Heyerick, D. de Keukeleire, 1999, Basic life sciences.

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

P. Lambin, L. Dubois, A. Jochems, 2021, Molecular Cancer Therapeutics.

Combined endogenous MR biomarkers to assess changes in tumor oxygenation induced by an allosteric effector of hemoglobin

B. Gallez, B. Jordan, N. Joudiou, 2019, NMR in biomedicine.

8-prenylnaringenin and tamoxifen inhibit the shedding of irradiated epithelial cells and increase the latency period of radiation-induced oral mucositis

W. De Neve, A. Van Impe, L. Vakaet, 2015, Strahlentherapie und Onkologie.

Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.

G. Haegeman, K. De Bosscher, M. Van Cleemput, 2009, Journal of natural products.

In Vitro Inhibition of the Transcription Factor NF‐κB and Cyclooxygenase by Bamboo Extracts

G. Haegeman, D. Deforce, K. De Bosscher, 2014, Phytotherapy research : PTR.

HlMyb3, a putative regulatory factor in hop (Humulus lupulus L.), shows diverse biological effects in heterologous transgenotes.

I. Roldán‐Ruiz, J. Matoušek, J. Škopek, 2007, Journal of agricultural and food chemistry.

Daucane esters from laserwort (Laserpitium latifolium L.) inhibit cytokine and chemokine production in human lung epithelial cells.

K. De Bosscher, J. Van der Eycken, A. Heyerick, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity.

S. van Calenbergh, D. Deforce, A. Heyerick, 2013, Phytochemistry.

Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines.

V. Castronovo, V. Castronovo, W. Dhooge, 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Piet Herdewijn, Veerle Vanheusden, Hélène Munier-Lehmann, 2003, Journal of medicinal chemistry.

Mechanism for formation of the lightstruck flavor in beer revealed by time-resolved electron paramagnetic resonance.

M. Forbes, A. Heyerick, D. de Keukeleire, 2001, Chemistry.

UNRAVELING THE MECHANISM OF THE LIGHTSTRUCK FLAVOR OF BEER

A. Heyerick, 2001 .

Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

Devanand L. Luthria, Tomikazu Sasaki, J. Ferreira, 2010, Molecules.

II International Humulus Symposium, Ghent, Belgium, 1-5 September 2008.

K. Hummer, A. Heyerick, D. Keukeleire, 2009 .

Withaferin A Strongly Elicits IκB Kinase β Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity*

G. Haegeman, J. Piette, C. Libert, 2007, Journal of Biological Chemistry.

The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals.

W. Verstraete, S. Possemiers, S. Bolca, 2011, Fitoterapia.

Modulation of the phytoestrogenicity of beer by monoterpene alcohols present in various hop oil fractions

S. Saeger, C. Peteghem, A. Heyerick, 2002 .

Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.

J. Philippé, G. Haegeman, C. Libert, 2009, Molecular nutrition & food research.

Antioxidant flavone glycosides from the leaves of Fargesia robusta.

S. van Calenbergh, D. Deforce, A. Heyerick, 2010, Journal of natural products.

Involvement of the Glucocorticoid Receptor in Pro-inflammatory Transcription Factor Inhibition by Daucane Esters from Laserpitium zernyi.

S. Eyckerman, K. De Bosscher, J. Van der Eycken, 2017, Journal of natural products.

Extracts of three Laserpitium L. species and their principal components laserpitine and sesquiterpene lactones inhibit microbial growth and biofilm formation by oral Candida isolates.

M. Soković, D. Stojković, A. Heyerick, 2015, Food & function.

Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo species.

T. De Beer, D. Deforce, A. Heyerick, 2012, Phytochemical analysis : PCA.

Prenylated chalcone xanthohumol associates with histones in breast cancer cells--a novel target identified by a monoclonal antibody.

D. Deforce, K. van Steendam, M. Bracke, 2012, Molecular nutrition & food research.

Mapping T and B cell epitopes in sperm protein 17 to support the development of an ovarian cancer vaccine.

K. Wilson, M. Plebanski, A. Heyerick, 2015, Vaccine.

Combinatorial analysis of lupulin gland transcription factors from R2R3Myb, bHLH and WDR families indicates a complex regulation of chs_H1 genes essential for prenylflavonoid biosynthesis in hop (Humulus Lupulus L.)

J. Matoušek, A. Heyerick, Zoltán Füssy, 2012, BMC Plant Biology.

Sequence analysis of a "true" chalcone synthase (chs_H1) oligofamily from hop (Humulus lupulus L.) and PAP1 activation of chs_H1 in heterologous systems.

D. Baulcombe, L. Vrba, J. Matoušek, 2006, Journal of agricultural and food chemistry.

Cloning and molecular analysis of the regulatory factor HlMyb1 in hop (Humulus lupulus L.) and the potential of hop to produce bioactive prenylated flavonoids.

I. Roldán‐Ruiz, L. Vrba, J. Matoušek, 2005, Journal of agricultural and food chemistry.

A Nanoparticle Based Sp17 Peptide Vaccine Exposes New Immuno-Dominant and Species Cross-reactive B Cell Epitopes

K. Wilson, M. Plebanski, A. Heyerick, 2015, Vaccines.

Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.).

I. Roldán‐Ruiz, G. Ooms, A. Heyerick, 2003, Journal of agricultural and food chemistry.

Design of Peptide-Based Nanovaccines Targeting Leading Antigens From Gynecological Cancers to Induce HLA-A2.1 Restricted CD8+ T Cell Responses

K. Wilson, M. Plebanski, A. Heyerick, 2018, Front. Immunol..

An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies

S. van Calenbergh, D. Deforce, S. de Saeger, 2014, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Disposition of soy isoflavones in normal human breast tissue.

P. Blondeel, C. Manach, M. Urpi-Sardà, 2010, The American journal of clinical nutrition.

Hop bitter acids efficiently block inflammation independent of GR a , PPAR a , or PPAR c

G. Haegeman, C. Libert, A. Heyerick, 2009 .

Twelve-month consumption of a polyphenol extract from olive (Olea europaea) in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with osteopenia

G. Raszewski, S. Possemiers, A. Heyerick, 2015, The journal of nutrition, health & aging.

Plant polyphenolics as anti-invasive cancer agents.

W. Verstraete, H. Depypere, C. Stevens, 2008, Anti-cancer agents in medicinal chemistry.

Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities.

F. Peschke, G. Weber, A. Heyerick, 2007, Journal of agricultural and food chemistry.

In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics.

Morwena J Solivio, P. Villalta, S. Balbo, 2022, Chemical research in toxicology.

Cytotoxic Activity of Laserpitium latifolium L. Extract and Its Daucane and Phenylpropanoid Constituents

D. Deforce, A. Heyerick, M. Niketić, 2013 .

Fate of flavins in sensitized photodegradation of isohumulones and reduced derivatives: studies on formation of radicals via EPR combined with detailed product analyses

M. Forbes, A. Heyerick, D. de Keukeleire, 2005, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Cloning and molecular analysis of HlbZip1 and HlbZip2 transcription factors putatively involved in the regulation of the lupulin metabolome in hop (Humulus lupulus L.).

I. Roldán‐Ruiz, J. Matoušek, K. Krofta, 2010, Journal of agricultural and food chemistry.

A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts.

S. Vansteelandt, R. Erkkola, A. Heyerick, 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Impact of myo‐inositol trispyrophosphate (ITPP) on tumour oxygenation and response to irradiation in rodent tumour models

B. Gallez, B. Jordan, A. Heyerick, 2018, Journal of cellular and molecular medicine.

Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.).

I. Roldán‐Ruiz, G. Ghekiere, E. Bockstaele, 2007, Journal of agricultural and food chemistry.

Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents.

W. Verstraete, H. Depypere, S. Possemiers, 2009, The Journal of nutrition.

Photooxidative degradation of beer bittering principles: a key step on the route to lightstruck flavor formation in beer.

L. Skibsted, M. Andersen, A. Heyerick, 2005, Journal of agricultural and food chemistry.

Radicaloid-type oxidative decomposition of beer bittering agents revealed.

L. Skibsted, K. Olsen, M. Andersen, 2003, Chemistry.

Prenylated hop flavonoids are key agents in relation to health-beneficial properties of beer

S. Milligan, A. Heyerick, D. Keukeleire, 2001 .

Bioavailability of hop-derived iso-α-acids and reduced derivatives.

J. Remon, D. Deforce, K. Boussery, 2011, Food & function.

Radical Scavenging Capacity of hop-derived Products

A. Heyerick, M. Biendl, L. V. Hoyweghen, 2010 .

A safety study of oral tangeretin and xanthohumol administration to laboratory mice.

H. Depypere, M. Bracke, A. Heyerick, 2005, In vivo.

A prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts

S. Lafay, H. Depypere, M. Bracke, 2009 .

Antioxidant Capacity and Secondary Metabolites of 12 Bamboo Species

D. Deforce, A. Heyerick, L. V. Hoyweghen, 2013 .

Photolysis of hop-derived trans-iso-α-acids and trans-tetrahydroiso-α-acids: product identification in relation to the lightstruck flavour of beer

P. Sandra, Yining Zhao, A. Heyerick, 2003, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Extracts of three Laserpitium L. species and their principal components laserpitine and sesquiterpene lactones inhibit microbial growth and biofilm formation by oral Candida isolates.

M. Soković, A. Heyerick, M. Niketić, 2015, Food & Function.

Feeding soybean meal increases the blood level of isoflavones and reduces the steroidogenic capacity in bovine corpora lutea, without affecting peripheral progesterone concentrations.

P. Bossaert, S. Cools, M. Hostens, 2014, Animal reproduction science.