R. Sá-Leão

N. Frazão, H. de Lencastre, R. Sá-Leão, 2009, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Genomic Characterization of the Emerging Pathogen Streptococcus pseudopneumoniae

H. Goossens, Geneviève Garriss, S. Browall, 2019, mBio.

Disease Isolates of Streptococcus pseudopneumoniae and Non-Typeable S. pneumoniae Presumptively Identified as Atypical S. pneumoniae in Spain

D. Rolo, H. de Lencastre, J. Liñares, 2013, PloS one.

Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002–2010)

R. Sá-Leão, A. S. Simões, M. P. Bajanca-Lavado, 2013, European Journal of Clinical Microbiology & Infectious Diseases.

Streptococcus pneumoniae nasopharyngeal carriage in children attending day-care centers in the central region of Portugal, in the era of 7-valent pneumococcal conjugate vaccine.

H. de Lencastre, R. Sá-Leão, S. Nunes, 2009, Microbial drug resistance.

Pilot Study of the Genetic Diversity of the Pneumococcal Nasopharyngeal Flora among Children Attending Day Care Centers

A. Tomasz, H. de Lencastre, R. Sá-Leão, 2002, Journal of Clinical Microbiology.

Puzzling Over the Pneumococcal Pangenome

N. Hiller, R. Sá-Leão, 2018, Front. Microbiol..

Global Phylogenomic Analysis of Nonencapsulated Streptococcus pneumoniae Reveals a Deep-Branching Classic Lineage That Is Distinct from Multiple Sporadic Lineages

W. Hanage, J. Parkhill, S. Bentley, 2014, Genome biology and evolution.

Comparative genomic analysis of the emerging pathogen Streptococcus pseudopneumoniae: novel insights into virulence determinants and identification of a novel species-specific molecular marker

H. Goossens, Geneviève Garriss, S. Browall, 2018, bioRxiv.

lytA-based identification methods can misidentify Streptococcus pneumoniae.

H. Goossens, B. Henriques-Normark, D. Rolo, 2016, Diagnostic microbiology and infectious disease.

Dynamics of pneumococcal carriage in adults: a new look at an old paradigm.

H. de Lencastre, R. Sá-Leão, S. T. Almeida, 2020, The Journal of infectious diseases.

The impact of private use of PCV7 in 2009 and 2010 on serotypes and antimicrobial resistance of Streptococcus pneumoniae carried by young children in Portugal: Comparison with data obtained since 1996 generating a 15-year study prior to PCV13 introduction.

H. de Lencastre, Carina Valente, R. Sá-Leão, 2016, Vaccine.

The blp Locus of Streptococcus pneumoniae Plays a Limited Role in the Selection of Strains That Can Cocolonize the Human Nasopharynx

J. Hinds, K. Gould, H. de Lencastre, 2016, Applied and Environmental Microbiology.

The blp locus of Streptococcus pneumoniae plays a limited role in the selection of which strains can co-colonize the human nasopharynx

J. Hinds, K. Gould, Carina Valente, 2016 .

Impact of the 13-valent pneumococcal conjugate vaccine on Streptococcus pneumoniae multiple serotype carriage.

J. Hinds, K. Gould, H. de Lencastre, 2016, Vaccine.

Temporal Trends and Molecular Epidemiology of Recently Described Serotype 6 C of Streptococcus pneumoniae

Carina Valente, R. Sá-Leão, S. Nunes, 2009 .

Temporal Trends and Molecular Epidemiology of Recently Described Serotype 6C of Streptococcus pneumoniae

H. de Lencastre, Carina Valente, R. Sá-Leão, 2008, Journal of Clinical Microbiology.

Epidemiology and Population Structure of Serotypes 1, 5 and 7F Carried by Children in Portugal from 1996-2010 before Introduction of the 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines

H. de Lencastre, R. Sá-Leão, S. T. Almeida, 2013, PloS one.

Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era.

H. de Lencastre, R. Sá-Leão, S. Nunes, 2008, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Rapid identification of noncapsulated Streptococcus pneumoniae in nasopharyngeal samples allowing detection of co-colonization and reevaluation of prevalence.

H. de Lencastre, Carina Valente, R. Sá-Leão, 2011, Diagnostic microbiology and infectious disease.

Highly Penicillin-Resistant Multidrug-Resistant Pneumococcus-Like Strains Colonizing Children in Oeiras, Portugal: Genomic Characteristics and Implications for Surveillance

João André Carriço, P. Hermans, H. Bootsma, 2009, Journal of Clinical Microbiology.

Using Whole Genome Sequencing to Investigate a Mock-Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in Real-Time.

M. Serrano, M. Miragaia, R. Sá-Leão, 2021, Acta medica portuguesa.

Impact of private use of the 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal carriage among Portuguese children living in urban and rural regions.

H. de Lencastre, Carina Valente, R. Sá-Leão, 2021, Vaccine.

Evidence for the intermediate disturbance hypothesis and exponential decay in replacement in Streptococcus pneumoniae following use of conjugate vaccines

R. Sá-Leão, A. C. Paulo, 2022, Scientific reports.

Optochin Resistance among Streptococcus pneumoniae Strains Colonizing Healthy Children in Portugal

H. de Lencastre, R. Sá-Leão, S. Nunes, 2007, Journal of Clinical Microbiology.

Carriage of multiple Streptococcus pneumoniae capsular types is frequent among children with invasive pneumococcal disease

D. Henares, C. Muñoz-Almagro, R. Sá-Leão, 2021, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.

Haemophilus influenzae Carriage among Healthy Children in Portugal, 2015–2019

R. Sá-Leão, A. S. Simões, M. P. Bajanca-Lavado, 2022, Microorganisms.

Variable recombination dynamics during the emergence, transmission and ‘disarming’ of a multidrug-resistant pneumococcal clone

A. Tomasz, W. Hanage, J. Parkhill, 2014, BMC Biology.

Streptococcus Pneumoniae Evolving – Impact of Antibiotics and Vaccines

A. Tomasz, R. Sá-Leão, 2014 .

Periodic cycles of pneumococcal serotypes carried by children before and after 7-valent pneumococcal conjugate vaccine

R. Sá-Leão, A. C. Paulo, 2017, PloS one.

Ability of Antibiotic-Resistant Nonvaccine-Type Pneumococcal Clones to Cause Otitis Media in an Infant Mouse Model of Pneumococcal-Influenza Virus Coinfection.

A. Tomasz, N. Frazão, H. de Lencastre, 2016, Microbial drug resistance.

Prevalence, risk factors, and epidemiology of methicillin-resistantStaphylococcus aureus carried by adults over 60 years of age

H. de Lencastre, R. Sá-Leão, S. Nunes, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Overview of molecular typing methods for outbreak detection and epidemiological surveillance.

A. Friedrich, H. Grundmann, A. Sabat, 2013, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

High Rates of Transmission of and Colonization by Streptococcus pneumoniae and Haemophilus influenzae within a Day Care Center Revealed in a Longitudinal Study

João André Carriço, H. de Lencastre, R. Sá-Leão, 2007, Journal of Clinical Microbiology.

High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines.

P. Brotons, C. Muñoz-Almagro, L. Selva, 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape

W. Hanage, J. Parkhill, K. Ko, 2014, Genome biology and evolution.

Diversity of penicillin-nonsusceptible Streptococcus pneumoniae circulating in Iceland after the introduction of penicillin-resistant clone Spain(6B)-2.

A. Tomasz, H. de Lencastre, R. Sá-Leão, 2002, The Journal of infectious diseases.

Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group.

K. O'Brien, J. Scott, A. Leach, 2013, Vaccine.

Properties of Novel International Drug-Resistant Pneumococcal Clones Identified in Day-Care Centers of Lisbon, Portugal

João André Carriço, N. Frazão, H. de Lencastre, 2005, Journal of Clinical Microbiology.

The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

W. Hanage, K. Ko, S. Bentley, 2021, eLife.

The Role of Interspecies recombinations in the evolution of antibiotic-resistant pneumococci

W. Hanage, K. Ko, S. Bentley, 2021, bioRxiv.

Differences in Genotype and Virulence among Four Multidrug-Resistant Streptococcus pneumoniae Isolates Belonging to the PMEN1 Clone

H. Tettelin, A. Tomasz, S. Daugherty, 2011, PloS one.

Identification of Streptococcus pneumoniae by a real-time PCR assay targeting SP2020

J. Hinds, H. de Lencastre, R. Sá-Leão, 2019, Scientific Reports.

Streptococcus pneumoniae carriage studies in adults: Importance, challenges, and key issues to consider when using quantitative PCR-based approaches

R. Sá-Leão, K. Trzciński, S. T. Almeida, 2023, Frontiers in Microbiology.

Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002–2010)

R. Sá-Leão, M. P. Bajanca-Lavado, A. Simões, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Serotypes and Clonal Composition of Streptococcus pneumoniae Isolates Causing IPD in Children and Adults in Catalonia before 2013 to 2015 and after 2017 to 2019 Systematic Introduction of PCV13

M. Benítez, C. Muñoz-Almagro, P. Ciruela, 2021, Microbiology spectrum.

Upper respiratory tract colonization with Streptococcus pneumoniae in adults

K. O'Brien, L. Danon, L. Hammitt, 2020, Expert review of vaccines.

Serotype Distribution, Antibiotic Resistance and Clonality of Streptococcus pneumoniae Isolated from Immunocompromised Patients in Tunisia

T. Ben Othman, M. Bejaoui, A. Ben Hassen, 2015, PloS one.

Virulence Potential and Genome-Wide Characterization of Drug Resistant Streptococcus pneumoniae Clones Selected In Vivo by the 7-Valent Pneumococcal Conjugate Vaccine

A. Tomasz, J. Earl, G. Ehrlich, 2013, PloS one.

Comparative analysis of Streptococcus pneumoniae transmission in Portuguese and Finnish day-care centres

K. Auranen, M. Gomes, R. Sá-Leão, 2013, BMC Infectious Diseases.

Pherotypes of co-colonizing pneumococci among Portuguese children.

H. de Lencastre, Carina Valente, R. Sá-Leão, 2012, Microbial drug resistance.

Decrease in Pneumococcal Co-Colonization following Vaccination with the Seven-Valent Pneumococcal Conjugate Vaccine

J. Hinds, K. Gould, K. Mühlemann, 2012, PloS one.

Large screening of CA-MRSA among Staphylococcus aureus colonizing healthy young children living in two areas (urban and rural) of Portugal

H. de Lencastre, M. Miragaia, R. Sá-Leão, 2010, BMC infectious diseases.

Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization.

N. Frazão, H. de Lencastre, R. Sá-Leão, 2010, Vaccine.

Non-typeable pneumococci circulating in Portugal are of cps type NCC2 and have genomic features typical of encapsulated isolates

H. de Lencastre, P. Hermans, H. Bootsma, 2014, BMC Genomics.

Analysis of Invasiveness of Pneumococcal Serotypes and Clones Circulating in Portugal before Widespread Use of Conjugate Vaccines Reveals Heterogeneous Behavior of Clones Expressing the Same Serotype

João A Carriço, Mário Ramirez, João André Carriço, 2011, Journal of Clinical Microbiology.

Denmark14-230 Clone as an Increasing Cause of Pneumococcal Infection in Portugal within a Background of Diverse Serotype 19A Lineages

M. Ramirez, H. de Lencastre, R. Sá-Leão, 2009, Journal of Clinical Microbiology.

Increase of Denmark 14-230 clone as a cause of pneumococcal infection in Portugal within a background of diverse serotype 19 A lineages 5

M. Ramirez, R. Sá-Leão, J. Melo-Cristino, 2009 .

Intra-Species Interactions in Streptococcus pneumoniae Biofilms

A. Henriques, Carina Valente, R. Sá-Leão, 2022, Frontiers in Cellular and Infection Microbiology.

How direct competition shapes coexistence and vaccine effects in multi-strain pathogen systems.

M. Gomes, Carina Valente, R. Sá-Leão, 2016, Journal of theoretical biology.

Evidence for the intermediate disturbance hypothesis and exponential decay in replacement in Streptococcus pneumoniae following use of conjugate vaccines

R. Sá-Leão, A. C. Paulo, 2022, Scientific Reports.

Identification of Streptococcus pneumoniae by a real-time PCR assay targeting SP2020

J. Hinds, H. de Lencastre, R. Sá-Leão, 2019, Scientific Reports.

Genetic Diversity and Clonal Patterns among Antibiotic-Susceptible and -Resistant Streptococcus pneumoniae Colonizing Children: Day Care Centers as Autonomous Epidemiological Units

Alexander Tomasz, A. B. Avô, A. Tomasz, 2000, Journal of Clinical Microbiology.

Carriage of internationally spread clones of Streptococcus pneumoniae with unusual drug resistance patterns in children attending day care centers in Lisbon, Portugal.

A. Tomasz, H. de Lencastre, H de Lencastre, 2000, The Journal of infectious diseases.

Prevalence, risk factors, and epidemiology of methicillin-resistantStaphylococcus aureus carried by adults over 60 years of age

R. Sá-Leão, S. Nunes, H. Lencastre, 2015, European Journal of Clinical Microbiology and Infectious Diseases.

Evaluation of Methicillin-Resistant Staphylococcus aureus Carriage in the Elderly in Portugal Using Selective Enrichment Followed by quantitative real-time PCR.

H. de Lencastre, R. Sá-Leão, A. C. Paulo, 2022, Microbial drug resistance.

Clonal Changes in the Pneumococcal Population Carried by Portuguese Children during Six Years of Private Use of the 13-Valent Pneumococcal Conjugate Vaccine: the Relative Contribution of Clonal Expansion, Clonal Emergence, and Capsular Switch Events

H. de Lencastre, R. Sá-Leão, Sofia Félix, 2023, Microbiology spectrum.

Trends in Drug Resistance, Serotypes, and Molecular Types of Streptococcus pneumoniae Colonizing Preschool-Age Children Attending Day Care Centers in Lisbon, Portugal: a Summary of 4 Years of Annual Surveillance

A. B. Avô, João André Carriço, H. de Lencastre, 2005, Journal of Clinical Microbiology.

Carriage and antibiotic resistance of respiratory pathogens and molecular epidemiology of antibiotic-resistant Streptococcus pneumoniae colonizing children in day-care centers in Lisbon: the Portuguese day-care center initiative.

A. Tomasz, H. de Lencastre, R. Sá-Leão, 1999, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

A low-cost molecular test for SARS-CoV-2 detection suitable for variant discrimination and community testing using saliva

M. Miragaia, R. Sá-Leão, N. Faria, 2023, medRxiv.

The upper respiratory tract microbiota of healthy adults is affected by Streptococcus pneumoniae carriage, smoking habits, and contact with children

M. Hilty, R. Sá-Leão, A. C. Paulo, 2023, Microbiome.

Streptococcus pneumoniae nasopharyngeal carriage in children attending day-care centers in the central region of Portugal, in the era of 7-valent pneumococcal conjugate vaccine.

H. de Lencastre, R. Sá-Leão, S. Nunes, 2009, Microbial drug resistance.

High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines.

R. Sá-Leão, M. Monsonís, E. Amo, 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.