C. Altomare

发表

Protein crystallography and fragment-based drug design.

Rocco Caliandro, R. Caliandro, M. de Candia, 2013, Future medicinal chemistry.

Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors.

G. Palazzo, A. De Stradis, M. Catto, 2011, European journal of medicinal chemistry.

Novel factor Xa inhibitors: a patent review

Cosimo Altomare, M. de Candia, C. Altomare, 2009, Expert opinion on therapeutic patents.

Determination of Lipophilicity and Hydrogen‐bond Donor Acidity of Bioactive Sulphonyl‐containing Compounds by Reversed‐phase HPLC and Centrifugal Partition Chromatography and their Application to Structure‐activity Relations

B. Testa, A. Carotti, N. Tayar, 1991, The Journal of pharmacy and pharmacology.

β‐D‐Glucosyl Conjugates of Highly Potent Inhibitors of Blood Coagulation Factor Xa Bearing 2‐Chorothiophene as a P1 Motif

M. Romano, C. Altomare, M. Lograno, 2012, ChemMedChem.

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa.

P. Carrupt, M. de Candia, S. Martel, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Determination of antitubercular drugs in human plasma by HPLC through direct injection.

A. Carotti, C. Altomare, S. Cellamare, 1990, Farmaco.

Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.

G. Biggio, G. Trapani, E. Sanna, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones

M. de Candia, M. Catto, L. Pisani, 2019, Molecules.

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

P. Carrupt, Alessandra Nurisso, N. Denora, 2015, Journal of medicinal chemistry.

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

P. Carrupt, B. Testa, F. Ooms, 2001, Journal of medicinal chemistry.

Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7‐Substituted Coumarins

B. Testa, P. Jenner, M. Catto, 2006, Chemistry & biodiversity.

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

O. Nicolotti, M. Catto, A. Carotti, 2013, Journal of medicinal chemistry.

Quantitative structure-metabolism relationship analyses of MAO-mediated toxication of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and analogues.

P. Carrupt, B. Testa, A. Carotti, 1992, Chemical research in toxicology.

X-ray crystal structure, partitioning behavior, and molecular modeling study of piracetam-type nootropics: insights into the pharmacophore.

B. Testa, A. Carotti, C. Altomare, 1995, Journal of medicinal chemistry.

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity.

Elisabetta Marini, M. de Candia, C. Altomare, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Organofluorine-containing therapeutics for treatment of cardiovascular disease

C. Altomare, M. Candia, 2015 .

Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents.

P. Fossa, A. Carotti, L. Mosti, 2000, Bioorganic & medicinal chemistry.

Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: advances in synthesis and medicinal chemistry.

C. Altomare, Rosa Purgatorio, L. Voskressensky, 2019, Future medicinal chemistry.

Neuronal nicotinic receptor agonists: a multi-approach development of the pharmacophore

Ferran Sanz, Cosimo Altomare, Antonio Carrieri, 2001, J. Comput. Aided Mol. Des..

2‐Benzazepine Nitrones Protect Dopaminergic Neurons against 6‐Hydroxydopamine‐Induced Oxidative Toxicity

A. V. Varlamov, V. P. Zaytsev, M. de Candia, 2012, Archiv der Pharmazie.

Electronic and Conformational Effects on the Lipophilicity of Isomers and Analogs of the Neurotoxin 1‐Methyl‐4‐phenylpyridinium (MPP+)

P. Carrupt, B. Testa, T. Nagatsu, 1991 .

Evaluation of Water‐Soluble Mannich Base Prodrugs of 2,3,4,5‐Tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as Multitarget‐Directed Agents for Alzheimer's Disease

N. Denora, M. Catto, L. Pisani, 2020, ChemMedChem.

Scouting around 1,2,3,4‐Tetrahydrochromeno[3,2‐c]pyridin‐10‐ones for Single‐ and Multitarget Ligands Directed towards Relevant Alzheimer's Targets

M. Catto, L. Pisani, C. Altomare, 2020, ChemMedChem.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

M. de Candia, M. Catto, L. Pisani, 2019, European journal of medicinal chemistry.

Inhibition of &agr;‐Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 ‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

P. Carrupt, B. Testa, K. McNaught, 1995, Neuroreport.

Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors.

A. V. Varlamov, M. de Candia, M. Catto, 2006, Bioorganic & medicinal chemistry.

The position of fluorine in CP‐118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain

M. de Candia, N. Denora, Sang Eun Kim, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones.

G. Biggio, F. Busonero, M. P. Mascia, 2003, Bioorganic & medicinal chemistry.

High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure-activity relationships and comparative molecular field analysis of pyrazolo[4,3-c]quinolin-3-ones.

G. Biggio, M. Serra, E. Maciocco, 2001, Bioorganic & medicinal chemistry.

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer’s Disease Potential

R. Borisov, M. de Candia, O. Nicolotti, 2021, Molecules.

Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes

G. Cavallaro, A. Marzullo, F. Prete, 2020, Scientific Reports.

3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance.

A. V. Varlamov, N. Colabufo, Mauro Niso, 2019, Future medicinal chemistry.

A New Class of 1‐Aryl‐5,6‐dihydropyrrolo[2,1‐a]isoquinoline Derivatives as Reversers of P‐Glycoprotein‐Mediated Multidrug Resistance in Tumor Cells

N. Colabufo, Mauro Niso, M. de Candia, 2018, ChemMedChem.

Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding.

G. Trapani, A. Carotti, C. Altomare, 1997, Journal of pharmaceutical sciences.

Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity

O. Nicolotti, M. Catto, L. Pisani, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmaceutical development of novel lactate‐based 6‐fluoro‐l‐DOPA formulations

M. de Candia, N. Denora, V. Laquintana, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

R. Sabaté, A. Espargaró, M. de Candia, 2020, Molecules.

Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.

P. Carrupt, B. Testa, M. Catto, 1998, Journal of medicinal chemistry.

Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.

P. Carrupt, B. Testa, A. Carotti, 1995, Journal of medicinal chemistry.

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

M. de Candia, O. Nicolotti, M. Catto, 2022, Molecules.

Antiplatelet 2‐Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events

N. Denora, C. Altomare, M. Candia, 2016 .

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

F. Leonetti, O. Nicolotti, M. Catto, 2022, Frontiers in Chemistry.

Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

C. Marsden, P. Carrupt, B. Testa, 1995, Neuroreport.

Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection

M. Papi, V. Palmieri, M. de Candia, 2022, Viruses.

Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase

E. Sotelo, R. Caliandro, B. D. Belviso, 2021, Separations.

1,2,3,4-Tetrahydroisoquinoline/2 H -chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1

N. Colabufo, Mauro Niso, L. Pisani, 2022 .

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.

P. Carrupt, R. Caliandro, M. de Candia, 2013, Journal of medicinal chemistry.

Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation.

M. de Candia, R. De Cristofaro, A. Carotti, 2009, Journal of medicinal chemistry.

Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation.

A. V. Varlamov, A. Carotti, C. Altomare, 2000, Bioorganic & medicinal chemistry letters.

Investigation on the antiplatelet activity of pyrrolo[3,2‐c]pyridine‐containing compounds

A. V. Varlamov, A. Carotti, C. Altomare, 2003, The Journal of pharmacy and pharmacology.

Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone.

P. Fossa, M. de Candia, A. Carotti, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Enantiomeric resolution of sulfoxides on a DACH-DNB chiral stationary phase: A quantitative structure-enantioselective retention relationship (QSERR) study

P. Carrupt, B. Testa, F. Gasparrini, 1993 .

Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery.

G. Biggio, G. Trapani, E. Sanna, 2000, Current medicinal chemistry.

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

M. de Candia, P. Mastrorilli, Vittorio Pace, 2017, Organic & biomolecular chemistry.

Tandem Cleavage of Hydrogenated β‐ and γ‐Carbolines − New Practical Synthesis of Tetrahydroazocino[4,5‐b]indoles and Tetrahydroazocino[5,4‐b]indoles Showing Acetylcholinesterase Inhibitory Activity

A. V. Varlamov, M. Catto, A. Carotti, 2004 .

Synthesis and monoamine oxidase inhibitory activity of 3-substituted 5H-indeno[1,2-c]pyridazines

B. Testa, A. Carotti, C. Altomare, 1993 .

Reductive domino reaction to access chromeno[2,3-c]isoquinoline-5-amines with antiproliferative activities against human tumor cells.

A. V. Varlamov, K. Subramani, A. Boccarelli, 2020, Bioorganic chemistry.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

R. Iacobazzi, N. Denora, M. Catto, 2019, European journal of medicinal chemistry.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

M. de Candia, F. De Santis, M. Catto, 2018, Molecules.

Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.

B. Testa, F. Leonetti, M. Catto, 2007, Journal of medicinal chemistry.

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

A. Linusson, M. de Candia, T. Latronico, 2022, Journal of medicinal chemistry.

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.

B Testa, P. Carrupt, B. Testa, 2000, Journal of medicinal chemistry.

Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors

A. V. Varlamov, M. Catto, C. Altomare, 2021, Molecular Diversity.

Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors

A. V. Varlamov, M. Catto, C. Altomare, 2021, Molecular Diversity.

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

N. Denora, G. Mangiatordi, O. Nicolotti, 2016, Molecules.

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.

A. Laghezza, M. Catto, F. Loiodice, 2022, European journal of medicinal chemistry.

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

M. de Candia, N. Denora, C. Altomare, 2017, European journal of medicinal chemistry.

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

N. Colabufo, Mauro Niso, L. Pisani, 2019, European journal of medicinal chemistry.

In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use

S. Haider, C. Tuleu, N. Denora, 2022, Pharmaceutics.

Lipophilicity measurements of benzenesulfonamide inhibitors of carbonic anhydrase by reversed-phase HPLC

A. Carotti, C. Altomare, S. Cellamare, 1989 .

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

M. de Candia, M. Catto, L. Pisani, 2018, Journal of separation science.

Recyclization of benzofuropyridines by the action of activated alkynes in the synthesis of spiro[benzofuropyridines], representatives of a new class of acetylcholinesterase inhibitors

A. V. Varlamov, A. Eresko, S. Kovaleva, 2013, Chemistry of Heterocyclic Compounds.

Measurement of partition coefficients by various centrifugal partition chromatographic techniques : A comparative evaluation

B. Testa, N. Tayar, P. Vallat, 1991 .

Substituent effects on the enantioselective retention of anti-HIV 5-aryl-delta 2-1,2,4-oxadiazolines on R,R-DACH-DNB chiral stationary phase.

F. Gasparrini, C. Villani, A. Carotti, 1996, Chirality.

Oxazolidinone Amide Antibiotics

C. Zaharia, C. Altomare, S. Cellamare, 2016 .

Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors.

G. Biggio, G. Trapani, E. Sanna, 1998, Journal of medicinal chemistry.

Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors

M. Catto, C. Altomare, Rosa Purgatorio, 2023, Molecules.

Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

C. Marsden, P. Carrupt, B. Testa, 1996, Neuroscience Letters.

A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

M. de Candia, M. Catto, L. Pisani, 2019, Molecules.

Galloyl benzamide‐based compounds modulating tumour necrosis factor α‐stimulated c‐Jun N‐terminal kinase and p38 mitogen‐activated protein kinase signalling pathways

F. Leonetti, A. Carotti, A. Stefanachi, 2015, The Journal of pharmacy and pharmacology.

Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes

G. Cavallaro, A. Marzullo, F. Prete, 2020, Scientific Reports.

Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats.

G. Bedse, T. Cassano, M. de Candia, 2017, Molecular pharmaceutics.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides

M. de Candia, N. Denora, A. Boccarelli, 2017, ChemMedChem.

Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives

C. Altamura, N. Denora, C. Altomare, 2017, Chemistry of Heterocyclic Compounds.

Mind the Gap! A Journey towards Computational Toxicology

Angelo Carotti, Saverio Cellamare, Daniela Trisciuzzi, 2016, Molecular informatics.

Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D2, serotonin, and GABAA receptors

E. Seu, G. Biggio, G. Trapani, 2002 .

Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.

E. Seu, G. Biggio, G. Trapani, 2002, Journal of medicinal chemistry.

A Stereoselective, Multicomponent Catalytic Carbonylative Approach to a New Class of α,β-Unsaturated γ-Lactam Derivatives

B. Gabriele, R. Mancuso, C. Altomare, 2021, Catalysts.

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease

M. de Candia, O. Nicolotti, M. Catto, 2021, Molecules.

Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.

M. de Candia, F. Zubkov, C. Altomare, 2008, Biochemical pharmacology.

Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides.

M. de Candia, A. Carotti, C. Altomare, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine

F. Fanizzi, A. Boccarelli, L. Del Coco, 2020, Molecules.

Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway.

B. Gabriele, O. Nicolotti, M. Catto, 2021, Biochemical Pharmacology.

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

M. de Candia, M. Catto, C. Altomare, 2022, Molecules.

Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

C. Marsden, P. Carrupt, B. Testa, 1995, Biochemical pharmacology.

LFER and CoMFA studies on optical resolution of α-alkyl α-aryloxy acetic acid methyl esters on DACH-DNB chiral stationary phase

Angelo Carotti, Cosimo Altomare, Saverio Cellamare, 1995, J. Comput. Aided Mol. Des..

The Hydrogen Bonding of Drugs: Its Experimental Determination and Role in Pharmacokinetics and Pharmacodynamics

P. Carrupt, B. Testa, A. Carotti, 1992 .

Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration.

C. Marsden, P. Carrupt, B. Testa, 1996, Biochemical pharmacology.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo‐ and Heterodimerization of Coumarin‐Based Moieties

M. Catto, L. Pisani, R. Farina, 2017, ChemMedChem.

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Lydia Siragusa, R. Iacobazzi, N. Denora, 2016, Journal of medicinal chemistry.

Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

C. Marsden, P. Carrupt, B. Testa, 1996, Biochemical pharmacology.

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases

M. Loza, M. Catto, C. Altomare, 2021, ChemMedChem.

Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids.

M. de Candia, A. Carotti, C. Altomare, 2003, Bioorganic & medicinal chemistry.

QSAR analysis of chemical and serum-catalyzed hydrolysis of phenyl ester prodrugs of nipecotic acid

A. Carotti, C. Altomare, S. Cellamare, 1988 .

Short-term anti-remodeling effects of gliflozins in diabetic patients with heart failure and reduced ejection fraction: an explainable artificial intelligence approach

N. Brunetti, N. Amoroso, A. De Luca, 2023, Frontiers in Pharmacology.

TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity

N. Amoroso, A. Monaco, R. Bellotti, 2022, J. Chem. Inf. Model..

Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.

C D Marsden, B Testa, C. Marsden, 1998, Biochemical pharmacology.

Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease

N. Colabufo, M. de Candia, J. Lopes, 2022, Pharmaceuticals.

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

A. Laghezza, M. Catto, F. Loiodice, 2022, Antioxidants.

Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids

A. Carotti, C. Altomare, F. Campagna, 1986, Steroids.

A simple synthesis of heterocyclic ring systems containing the 1,3-oxazine nucleus

Giovanni Casini, A. Carotti, C. Altomare, 1984, Journal of Heterocyclic Chemistry.

Heterocyclic steroids. II. Synthesis of some spiro derivatives of 7,8‐diaza‐11‐oxasteroids

A. Carotti, C. Altomare, F. Campagna, 1983 .

Binding models of reversible inhibitors to type-B monoamine oxidase

M. Letizia Barreca, Cosimo Altomare, Antonio Carrieri, 2002, J. Comput. Aided Mol. Des..

Reversible inhibition of MAO-A and B by diazoheterocyclic compounds: Development of QSAR/CoMFA models

P. Carrupt, B. Testa, A. Carotti, 2000 .

2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line.

V. Papadopoulos, N. Denora, V. Laquintana, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Linear Solvation Energy Relationships in Reversed‐Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters

A. Carotti, C. Altomare, S. Cellamare, 1993 .

An Efficient Route to Biologically Active 5H-Indeno(1,2-c)pyridazin-5- ones.

A. Carotti, C. Altomare, F. Campagna, 1993 .

Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents.

N. Denora, O. Nicolotti, M. Catto, 2021, ACS chemical neuroscience.

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Rémi Legay, M. Catto, P. Dallemagne, 2020, Molecules.

The natural mutation by deletion of Lys9 in the thrombin A‐chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding

P. Mannucci, F. Peyvandi, R. Palla, 2006, The FEBS journal.

A Natural Prothrombin Mutant Reveals an Unexpected Influence of A-chain Structure on the Activity of Human α-Thrombin*

P. Mannucci, R. De Cristofaro, F. Peyvandi, 2004, Journal of Biological Chemistry.

Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.

I. Silman, E. de la Mora, J. Colletier, 2020, ACS medicinal chemistry letters.

Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.

J. Handzlik, Rafał Kurczab, G. Satała, 2023, European journal of medicinal chemistry.

Galloyl benzamide‐based compounds modulating tumour necrosis factor α‐stimulated c‐Jun N‐terminal kinase and p38 mitogen‐activated protein kinase signalling pathways

F. Leonetti, A. Carotti, A. Stefanachi, 2015, The Journal of pharmacy and pharmacology.

Interplay Between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives.

M. de Candia, Antonio Viayna, C. Altomare, 2019, The journal of physical chemistry. B.

Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationships.

P. Carrupt, B. Testa, K. McNaught, 1995, Biochemical pharmacology.

Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography

G. Trapani, C. Altomare, M. Franco, 1995 .

Lipophilicity of Teicoplanin Antibiotics as Assessed by Reversed Phase High‐performance Liquid Chromatography: Quantitative Structure‐property and Structure‐activity Relationships

A. Carotti, C. Altomare, A. Carrieri, 1994, The Journal of pharmacy and pharmacology.

A second life for MAO inhibitors? From CNS diseases to anticancer therapy.

M. de Candia, M. Catto, C. Altomare, 2024, European journal of medicinal chemistry.

Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity

M. de Candia, A. Cappelli, F. Corelli, 2023, Molecules.

How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.

R. Caliandro, M. de Candia, B. D. Belviso, 2014, Journal of medicinal chemistry.

Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

C. Altomare, 2017, Chemistry of Heterocyclic Compounds.

A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics

M. de Candia, M. Catto, L. Pisani, 2024, Antioxidants.

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity.

A. Liantonio, F. Bonifazi, O. Nicolotti, 2024, Chemical research in toxicology.

Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal

O. Nicolotti, C. Altomare, Nicola Gambacorta, 2024, Viruses.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides

M. de Candia, N. Denora, A. Boccarelli, 2017, ChemMedChem.

Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.

M. de Candia, O. Nicolotti, M. Catto, 2024, European journal of medicinal chemistry.

New strategies in the chemotherapy of leukemia: eradicating cancer stem cells in chronic myeloid leukemia.

F. Leonetti, O. Nicolotti, M. Catto, 2012, Current cancer drug targets.

Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives.

O. Nicolotti, F. Ciriaco, Daniela Trisciuzzi, 2023, Expert opinion on drug metabolism & toxicology.

Radiosynthesis and whole‐body distribution in mice of a 18F‐labeled azepino[4,3‐b]indole‐1‐one derivative with multimodal activity for the treatment of Alzheimer's disease

P. Tucci, M. de Candia, N. Denora, 2023, Archiv der Pharmazie.