Robert Downham

发表

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Gianni Chessari, Brent Graham, Christopher W Murray, 2010, Journal of medicinal chemistry.

Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.

S. Ley, D. Entwistle, P. Edwards, 1995 .

1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.

A. Ayscough, A. Ivetac, A. Hendrick, 2017, Journal of Medicinal Chemistry.

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Marcel L Verdonk, Paul G Wyatt, Michelle D Garrett, 2007, Journal of medicinal chemistry.

Asymmetric Construction of the Diazatricyclic Core of the Marine Alkaloids Sarains A−C

L. Overman, Fay W Ng, Robert Downham, 1998 .

Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates

S. Ley, G. Boons, Robert Downham, 1994 .

Total synthesis of the protein phosphatase inhibitor okadaic acid

S. Ley, J. Pietruszka, Robert Downham, 1998 .

Dispiroketals: a new functional group for organic synthesis

S. Ley, P. Edwards, Robert Downham, 1996 .

Dispiroketals in Synthesis. Part 19. Dispiroketals as Enantioselective and Regioselective Protective Agents for Symmetric Cyclic and Acyclic Polyols.

S. Ley, D. Entwistle, P. Edwards, 1996 .

Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.

Gianni Chessari, Brent Graham, Jose Cosme, 2010, Journal of medicinal chemistry.

Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates☆

S. Ley, Robert Downham, K. Kim, 1994 .

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

D. Duncker, D. Merkus, Robert Downham, 2021, Basic Research in Cardiology.

Total synthesis of (+)-sarain A.

L. Overman, C. Douglas, R. Matsuoka, 2006, Journal of the American Chemical Society.

Structure‐activity studies on prolactin‐releasing peptide (PrRP). Analogues of PrRP‐(19–31)‐peptide

J. Humphries, Robert Downham, T. Ganguly, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

M. Congreve, C. Murray, G. Chessari, 2010, Journal of medicinal chemistry.

Total synthesis of (+)-sarain A.

L. Overman, C. Douglas, R. Matsuoka, 2007, Journal of the American Chemical Society.