J. Sigman

发表

Construction and characterization of a manganese-binding site in cytochrome c peroxidase: towards a novel manganese peroxidase.

B. Yeung, X. Wang, J. Sigman, 1997, Chemistry & biology.

Erratum: Beraprost therapy for pulmonary arterial hypertension (Journal of the American College of Cardiology (2003) 41 (2119-2125))

K. Wasserman, S. Rich, R. Barst, 2003 .

Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial.

D. Badesch, A. Frost, A. Keogh, 2012, Chest.

Efficacy and Safety of Treprostinil: An Epoprostenol Analog for Primary Pulmonary Hypertension

S. Rich, R. Barst, D. Badesch, 2003, Journal of cardiovascular pharmacology.

Design and Creation of a Cu(II)-Binding Site in Cytochrome c Peroxidase that Mimics the CuB-heme Center in Terminal Oxidases

Yi Lu, Yi Lu, Jeffrey A. Sigman, 1999 .

Flexibility in substrate recognition by thimet oligopeptidase as revealed by denaturation studies.

Tasneem H. Patwa, M. Glucksman, A. Wolfson, 2005, The Biochemical journal.

The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin

Yi Lu, Xuan Zhao, Yi Lu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Coupled oxidation of heme by myoglobin is mediated by exogenous peroxide.

X. Wang, J. Sigman, Y. Lu, 2001, Journal of the American Chemical Society.

Engineering cytochrome c peroxidase into cytochrome P450: a proximal effect on heme-thiolate ligation.

J. Dawson, Y. Lu, J H Dawson, 1999, Biochemistry.

Beraprost therapy for pulmonary arterial hypertension.

K. Wasserman, S. Rich, R. Barst, 2003, Journal of the American College of Cardiology.

Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form

A. Wolfson, J. Sigman, Yu Liu, 2021, Immuno.

Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction

Yi Lu, Roshan Perera, Yi Lu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

From Myoglobin to Heme-Copper Oxidase: Design and Engineering of a CuB Center into Sperm Whale Myoglobin

Yi Lu, Yi Lu, Jeffrey A. Sigman, 2000 .

Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection

M. Glucksman, A. Wolfson, J. Sigman, 2008, The FEBS journal.

Involvement of surface cysteines in activity and multimer formation of thimet oligopeptidase.

M. Glucksman, A. Wolfson, J. Sigman, 2003, Protein engineering.

The role of copper and protons in heme-copper oxidases: kinetic study of an engineered heme-copper center in myoglobin.

Yi Lu, James R. Carey, J. Sigman, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Title : A mechanistic and structural investigation of the hinge-bend conformation of metallopeptidases :

J. Sigman, T. Sosa, 2011 .

pH dependence studies provide insight into the structure and mechanism of thimet oligopeptidase (EC 3.4.24.15)

M. Glucksman, A. Wolfson, J. Sigman, 2003, FEBS letters.