D. Holsworth

发表

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.

N. Powell, Michael D. Kaufman, S. D. Emerson, 2007, Analytical biochemistry.

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors.

N. Powell, D. Downing, M. Jalaie, 2005, Bioorganic & medicinal chemistry.

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.

Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization.

N. Powell, D. Downing, W. L. Cody, 2004, Organic letters.

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

S. Krauss, D. Petersen, I. Okun, 2011, PloS one.

Recent Advances in Wnt/β-Catenin Pathway Small-Molecule Inhibitors

S. Krauss, D. Holsworth, D. D. Holsworth, 2012 .

Use of electrospray ionization mass spectrometry to probe antisense peptide interactions.

J. Loo, R. Root-Bernstein, D. Holsworth, 1994, Biological mass spectrometry.

An Expeditious Synthesis of 6-Alkyl-5-(4′-amino-phenyl)-pyrimidine-2,4-diamines

D. Holsworth, S. Maiti, J. Edmunds, 2003 .

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.

G. Drewes, H. Dinh, S. Krauss, 2013, Journal of medicinal chemistry.

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry.

Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.

N. Powell, M. J. Ryan, M. Jalaie, 2005, Bioorganic & medicinal chemistry letters.

Vinyl isocyanates in synthesis. [4+2] cycloaddition reactions with benzyne addends

D. Holsworth, J. H. Rigby, K. James, 1989 .

A convenient large-scale chiral synthesis of protected 2-substituted 4-oxo-piperidine derivatives

J. Kilburn, H. Andersen, T. Hansen, 2002 .

Total synthesis of N-nornitidine

D. Holsworth, J. H. Rigby, J. Rigby, 1991 .

Synthesis of 4‐(R)‐Naphthalene‐2‐yloxy‐1‐(1‐Phenyl‐(S)‐Ethyl)‐Pyrrolidin‐3‐(R)‐ol and 4‐(S)‐Naphthalen‐2‐yloxy‐1‐(1‐Phenyl‐(S)‐Ethyl)‐Pyrrolidin‐3‐(S)‐ol: Versatile Chiral Intermediates for Synthesis

D. Holsworth, M. Stier, S. Maiti, 2004 .

Optimization of a Pd-catalyzed intramolecular α-arylation synthesis of tricyclo-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones

N. Powell, R. Kennedy, F. Ciske, 2010 .

Augmentation of aortic ring contractions by angiotensin II antisense peptide.

R. Root-Bernstein, P. Dillon, D. Holsworth, 1998, Hypertension.

Structure-based Design of Selective and Potent Inhibitors of Protein-tyrosine Phosphatase β*

M. J. Newman, O. Olsen, L. Iversen, 2004, Journal of Biological Chemistry.

Biochemical characterization of a novel high‐affinity and specific plasma kallikrein inhibitor

D. Kolte, Z. Shariat-Madar, D. Holsworth, 2011, British journal of pharmacology.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

S. Krauss, M. Merchant, P. Polakis, 2013, Cancer research.

Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta.

M. J. Newman, O. Olsen, L. Iversen, 2004, Journal of Biological Chemistry.

Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase

G. S. Walker, R. Voorman, D. Holsworth, 2006, Drug Metabolism and Disposition.

A Facile Synthesis of Racemic 2-Aminomethyl-4-oxo-piperidine Intermediates

T. Hansen, D. Holsworth, J. Lau, 2003 .

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

M. J. Newman, O. Olsen, G. Peters, 2001, Biochemistry.

IMPROVED LARGE SCALE SYNTHESIS OF 2-TRIMETHYLSILOXY-1,3-BUTADIENE

D. Holsworth, Phong H. Vu, R. Uyeda, 2002 .

Improved Large-Scale Synthesis of 2-Trimethylsiloxy-1,3-butadiene.

D. Holsworth, Phong H. Vu, R. Uyeda, 2002 .

CARDIOVASCULAR AGENTS : RENIN INHIBITORS AND FACTOR Xa INHIBITORS

R. Subedi, D. Holsworth, M. Stier, 2007 .