R. Patton

发表

Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.

M. Snow, P. Weber, P. Kirschmeier, 2002, Journal of medicinal chemistry.

SCH 58450, a novel farnesyl protein transferase inhibitor possessing a 6a,12a:7,12-diepoxybenz[a]anthracene ring system

W. R. Bishop, R. Patton, Mahesh Patel, 1995 .

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase

W. R. Bishop, P. Kirschmeier, J. Schwartz, 1995, The Journal of Biological Chemistry.

A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli

W. R. Bishop, A. McPhail, R. Patton, 1996 .

Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses.

E. Thrower, A. Raoof, F. Gorelick, 2012, American journal of physiology. Gastrointestinal and liver physiology.

and enhances pancreatitis responses 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates Tobacco carcinogen

E. Thrower, A. Raoof, F. Gorelick, 2012 .

Analogues of 1-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta [1,2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase.

W. R. Bishop, T. Guzi, A. Nomeir, 1999, Bioorganic & medicinal chemistry.

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.

W. R. Bishop, P. Kirschmeier, L. Wang, 1998, Journal of medicinal chemistry.

Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of (5,6‐Dihydro‐11H‐benzo[5,6]cyclohepta [1,2‐b]pyridin‐11‐ylidene)‐1‐piperidine‐N‐cyanoguanidine Derivatives (I) as Inhibitors of Ras Farnesyl Protein Transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002 .

Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine.

Walter A. Korfmacher, W. R. Bishop, J. Chen, 1998, Journal of medicinal chemistry.

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.

W. R. Bishop, J. Catino, M. Malkowski, 1997, Journal of medicinal chemistry.

Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I*

W. R. Bishop, P. Kirschmeier, W. Windsor, 1997, The Journal of Biological Chemistry.

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase BIOCHEMICAL CHARACTERIZATION AND INHIBITION OF Ras MODIFICATION IN TRANSFECTED Cos CELLS*

P. Kirschmeier, J. Catino, R. Doll, 1995 .