Leon Aarons

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Incorporating physiological and biochemical mechanisms into pharmacokinetic-pharmacodynamic models: a conceptual framework.

Yves-Jacques Schneider, Svein G Dahl, Leon Aarons, 2009, Basic & clinical pharmacology & toxicology.

Application of optimal design methodologies in clinical pharmacology experiments

Leon Aarons, Kayode Ogungbenro, Aristides Dokoumetzidis, 2009, Pharmaceutical statistics.

A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

Gordon Graham, Leon Aarons, Kayode Ogungbenro, 2007, Comput. Methods Programs Biomed..

Critical Analysis and Communication: An Alternative to the Research Project

Leon Aarons, Constantinos Demonacos, Jill Barber, 2014 .

Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data

Leon Aarons, Kayode Ogungbenro, Thierry Wendling, 2015, The AAPS Journal.

A method for robust model order reduction in pharmacokinetics

Leon Aarons, Aristides Dokoumetzidis, L. Aarons, 2009, Journal of Pharmacokinetics and Pharmacodynamics.

Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

Leon Aarons, Thierry Wendling, Nikolaos Tsamandouras, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Optimal design of pharmacokinetic studies.

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2010, Basic & clinical pharmacology & toxicology.

Propagation of Population PK and PD Information Using a Bayesian Approach: Dealing with Non-Exchangeability

Leon Aarons, Aristides Dokoumetzidis, L. Aarons, 2006, Journal of Pharmacokinetics and Pharmacodynamics.

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Leon Aarons, Amin Rostami-Hodjegan, Nikolaos Tsamandouras, 2015, British journal of clinical pharmacology.

The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments

Gordon Graham, Leon Aarons, Kayode Ogungbenro, 2005, Comput. Methods Programs Biomed..

Propagation of Population Pharmacokinetic Information Using a Bayesian Approach: Comparison with Meta-Analysis

Leon Aarons, Aristides Dokoumetzidis, L. Aarons, 2005, Journal of Pharmacokinetics and Pharmacodynamics.

Optimal Design for Multiresponse Pharmacokinetic–Pharmacodynamic Models – Dealing with Unbalanced Designs

Gordon Graham, Leon Aarons, Kayode Ogungbenro, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

PBPK models for the prediction of in vivo performance of oral dosage forms.

Martin Bergstrand, Xavier Pepin, Erik Sjögren, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Structural identifiability analysis of pharmacokinetic models using DAISY: semi-mechanistic gastric emptying models for 13C-octanoic acid

Leon Aarons, Kayode Ogungbenro, 2011, Journal of Pharmacokinetics and Pharmacodynamics.

An Effective Approach for Obtaining Optimal Sampling Windows for Population Pharmacokinetic Experiments

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2008, Journal of biopharmaceutical statistics.

Effect of experimental design on assay calibration

Leon Aarons, 1981 .

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

Leon Aarons, France Mentré, Kayode Ogungbenro, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

Critical Analysis and Communication: an alternative to the final year project

Leon Aarons, Constantinos Demonacos, Jill Barber, 2014 .

Determination of an Optimal Dosage Regimen Using a Bayesian Decision Analysis of Efficacy and Adverse Effect Data

Gordon Graham, Leon Aarons, Suneel Gupta, 2002, Journal of Pharmacokinetics and Pharmacodynamics.

Optimal Design for Drug-Drug Interaction Study Using PopDes - Application to SX and MDZ” and “PopDes - An Optimal Experimental Design Program for Individual and Population Uniresponse and Multiresponse PKPD models

Leon Aarons, Kayode Ogungbenro, Marylore Chenel, 2007 .

"The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling". In: Case Studies in Bayesian Statistics (Vol IV), Lecture Notes in Statistics

Amy Racine-Poon, Leon Aarons, Jon Wakefield, 1999 .

Incorporating Correlation in Interindividual Variability for the Optimal Design of Multiresponse Pharmacokinetic Experiments

Leon Aarons, Kayode Ogungbenro, Ivelina Gueorguieva, 2008, Journal of biopharmaceutical statistics.

Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model.

Andrés Olivares-Morales, Leon Aarons, Adam S Darwich, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat

Leon Aarons, Jaap W. Mandema, Meindert Danhof, 1991, Journal of Pharmacokinetics and Biopharmaceutics.

Editorial: Pharmacokinetic and pharmacodynamic modelling in drug development

Leon Aarons, 1999 .

A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2014, Pharmaceutical Research.

Population pharmacokinetics and pharmacodynamics of warfarin in healthy young adults

Malcolm Rowland, Leon Aarons, L. Aarons, 1993 .

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.

Munir Pirmohamed, Steven Lane, Leon Aarons, 2012, British journal of clinical pharmacology.

Optimum blood sampling time windows for parameter estimation in population pharmacokinetic experiments

Leon Aarons, L. Aarons, Gordon Graham, 2006, Statistics in medicine.

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Andrés Olivares-Morales, Leon Aarons, Aleksandra Galetin, 2013, Pharmaceutical Research.

Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCl (LY335979)

Atul Mehta, Leon Aarons, Sophie Callies, 2004, Cancer Chemotherapy and Pharmacology.

Markov Chain Monte Carlo Techniques for Studying Interoccasion and Intersubject Variability: Application to Pharmacokinetic Data

David J. Lunn, Leon Aarons, David Lunn, 1997 .

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Optimisation of sampling windows design for population pharmacokinetic experiments

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

The kinetics of flurbiprofen in synovial fluid

Leon Aarons, L. Aarons, 1991, Journal of pharmacokinetics and biopharmaceutics.

Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

Paolo Magni, Leon Aarons, Adam S Darwich, 2018, Journal of Pharmacokinetics and Pharmacodynamics.

Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin

Avijit Ghosh, Andrés Olivares-Morales, Leon Aarons, 2016, The AAPS Journal.

Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects

Leon Aarons, Kayode Ogungbenro, Thierry Wendling, 2014, Pharmaceutical Research.

Structural identifiability analysis and reparameterisation (parameter reduction) of a cardiovascular feedback model.

Leon Aarons, James W T Yates, Oneeb Majid, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Empirical and Semi-Mechanistic Modelling of Double-Peaked Pharmacokinetic Profile Phenomenon Due to Gastric Emptying

Leon Aarons, Kayode Ogungbenro, Henry Pertinez, 2014, The AAPS Journal.

IMI – oral biopharmaceutics tools project – evaluation of bottom‐up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Xavier Pepin, Leon Aarons, Hans Lennernäs, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Use of Population Pharmacokinetics in Drug Development

France Mentré, Malcolm Rowland, Leon Aarons, 1996, Clinical pharmacokinetics.

Optimal Design for Multivariate Response Pharmacokinetic Models

Malcolm Rowland, Leon Aarons, Kayode Ogungbenro, 2006, Journal of Pharmacokinetics and Pharmacodynamics.

Drug–drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

Leon Aarons, Kayode Ogungbenro, François Bouzom, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

Leon Aarons, Marylore Chenel, L. Aarons, 2013, Pharmaceutical Research.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Modelling and Simulation in the Development and use of Anti-Cancer Agents: An Underused Tool?

France Mentré, Leon Aarons, Amy Racine, 2004, Journal of Pharmacokinetics and Pharmacodynamics.

STRUCTURAL IDENTIFIABILITY OF PARALLEL PHARMACOKINETIC EXPERIMENTS AS CONSTRAINED SYSTEMS

Leon Aarons, S. Y. Amy Cheung, L. Aarons, 2006 .

Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

Leon Aarons, Alison Margolskee, Jennifer Dressman, 2016, The Journal of pharmacy and pharmacology.

The Pharmacokinetics of Saquinavir: A Markov Chain Monte Carlo Population Analysis

David J. Lunn, Leon Aarons, L. Aarons, 1998, Journal of Pharmacokinetics and Biopharmaceutics.

Analytical Expressions for Combining Population Pharmacokinetic Parameters from Different Studies

Leon Aarons, Aristides Dokoumetzidis, L. Aarons, 2008, Journal of biopharmaceutical statistics.

How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2008, European Journal of Clinical Pharmacology.

An Identifiability Analysis of a Parent–Metabolite Pharmacokinetic Model for Ivabradine

Keith R. Godfrey, Neil D. Evans, Michael J. Chappell, 2001, Journal of Pharmacokinetics and Pharmacodynamics.

Sample Size Calculations for Population Pharmacodynamic Experiments Involving Repeated Dichotomous Observations

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2007, Journal of biopharmaceutical statistics.

Bayesian Optimal Designs for Pharmacokinetic Models: Sensitivity to Uncertainty

Leon Aarons, Aristides Dokoumetzidis, L. Aarons, 2007, Journal of biopharmaceutical statistics.

Sample Size Calculations Based on Generalized Estimating Equations for Population Pharmacokinetic Experiments

Leon Aarons, Kayode Ogungbenro, L. Aarons, 2006, Journal of biopharmaceutical statistics.

Comparison of in‐vivo and in‐silico methods used for prediction of tissue: plasma partition coefficients in rat

Leon Aarons, Aleksandra Galetin, James Yates, 2012, The Journal of pharmacy and pharmacology.

Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine

France Mentré, Leon Aarons, Stephen B Duffull, 2004, Pharmaceutical Research.

Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

Leon Aarons, Kayode Ogungbenro, Thierry Wendling, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

James W. T. Yates, Leon Aarons, Emma C. Martin, 2016, Cancer Chemotherapy and Pharmacology.

Intravenous Phenytoin Loading in Patients after Neurosurgery and in Status Epilepticus

Leon Aarons, Hans Landolt, O. Gratzl, 1988, Clinical pharmacokinetics.

The design and analysis of parallel experiments to produce structurally identifiable models

James W. T. Yates, Leon Aarons, S. Y. Amy Cheung, 2013, Journal of Pharmacokinetics and Pharmacodynamics.

Modeling and Simulation for Clinical Trial Design Involving a Categorical Response: A Phase II Case Study with Naratriptan

Stephen Duffull, Leon Aarons, Ivan Nestorov, 2001, Pharmaceutical Research.

Optimal Blood Sampling Time Windows for Parameter Estimation Using a Population Approach: Design of a Phase II Clinical Trial

Leon Aarons, Kayode Ogungbenro, Marylore Chenel, 2005, Journal of Pharmacokinetics and Pharmacodynamics.

Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

Leon Aarons, Dennis E. Kyle, Julie A. Simpson, 2000, Antimicrobial Agents and Chemotherapy.

Uncertainty Analysis in Pharmacokinetics and Pharmacodynamics: Application to Naratriptan

Malcolm Rowland, Leon Aarons, Ivelina Gueorguieva, 2005, Pharmaceutical Research.

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Leon Aarons, Nikolaos Tsamandouras, Aleksandra Galetin, 2014, Pharmaceutical Research.

Pharmacokinetics of a Single Bolus of Propofol in Chinese Children of Different Ages

Nick Freemantle, Leon Aarons, N. Freemantle, 2006, Anesthesiology.

Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

Leon Aarons, Ivelina Gueorguieva, Mats Karlsson, 2007, European Journal of Clinical Pharmacology.