A. Doble

A. Doble, P. Kennel, 2000, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

Degradation of atrial natriuretic peptides by an enzyme in rat kidney resembling neutral endopeptidase 24.11.

A. Doble, P. Bertrand, 1988, Biochemical pharmacology.

Pharmacological characterization of RP 62203, a novel 5‐hydroxytryptamine 5‐HT2 receptor antagonist

D. Girdlestone, A. Dupuy, C. Gueremy, 1992, British journal of pharmacology.

Measurement of nerve growth factor-like immunoreactivity in human brain using an anti-mouse-NGF enzyme immunoassay

R. Houlgatte, F. Javoy‐Agid, J. Brandel, 1992, Neurochemistry International.

Prevalence of benign prostatic hyperplasia among the adult general population of five Middle Eastern Countries: Results of the SNAPSHOT programme

L. Tariq, A. El Hasnaoui, M. Binbay, 2022, Arab journal of urology.

Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity.

P. Cuatrecasas, A. Saltiel, A. Doble, 1983, Biochemical and biophysical research communications.

6-Hydroxydopamine decreases benzodiazepine but not GABA receptor binding in rat cerebellum

L. Iversen, N. Bowery, A. Hudson, 1981, Neuroscience Letters.

Neuroprotective compounds inhibit depolarisation‐evoked calcium transients in granule cells

A. Doble, J. Hubert, 1998 .

Neuroprotective effects of riluzole on N-methyl-d-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices

C. Malgouris, A. Doble, M. Daniel, 1994, Neuroscience Letters.

The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis

G. Bensimon, A. Doble, 2004, Expert opinion on drug safety.

Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. Pharmacological characterization of [3H]RP 62203 binding in the rat brain.

C. Malgouris, A. Doble, F. Flamand, 1993, European journal of pharmacology.

β-Chlorophenyl GABA (Baclofen) is a selective ligand for a novel GABA receptor on nerve terminals

N. Bowery, A. Hudson, J. Shaw, 1979, Brain Research Bulletin.

Doble et al. reply

A. Doble, E. Louvel, 1998 .

Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on d[3H]aspartate release from cultured cerebellar granule cells

A. Doble, J. Blanchard, J. Hubert, 1992, Neuroscience Letters.

Characterization of a Human NK1 Tachykinin Receptor in the Astrocytoma Cell Line U 373 MG

A. Doble, E. Heuillet, C. Garret, 1993, Journal of neurochemistry.

A Novel Gaba Receptor on Central Neurones

N. Bowery, A. Hudson, J. Shaw, 1980 .

RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.

J. Stutzmann, T. Canton, A. Doble, 1993, The Journal of pharmacology and experimental therapeutics.

Interaction of brain cannabinoid receptors with guanine nucleotide binding protein: a radioligand binding study.

F. Petitet, M. Capet, A. Doble, 1997, Biochemical pharmacology.

Multiple benzodiazepine receptors: structures in the brain or structures in the mind? A critical review.

I. Martin, A. Doble, C. Brown, 1983, Life sciences.

Structure/activity studies at a baclofen-sensitive, bicuculline-insensitive GABA receptor.

N. Bowery, A. Hudson, A. Doble, 1981, Advances in biochemical psychopharmacology.

Partial purification and pharmacology of peripheral-type benzodiazepine receptors.

G. Le Fur, A. Uzan, F. Bégassat, 1987, Journal of receptor research.

The Benzodiazepine Receptor in Rat Brain and Its Interaction with Ethyl /3‐Carboline‐3‐Carboxylate

I. Martin, A. Doble, Ian L. Martin, 1983, Journal of neurochemistry.

Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative.

P. Laduron, C. Malgouris, A. Doble, 1994, Bioorganic & medicinal chemistry.

Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines.

S. Mignani, P. Hubert, J. Stutzmann, 1999, Journal of medicinal chemistry.

[Tools for assessing patient perception of the impact of migraine].

A. Gaudin, A. El Hasnaoui, A. Doble, 2006, CNS drugs.

Possible involvement of nitric oxide in long-term potentiation.

G. Böhme, J. Stutzmann, C. Bon, 1991, European journal of pharmacology.

New indole derivatives as potent and selective serotonin uptake inhibitors.

S. Mignani, P. Laduron, C. Gueremy, 1993, Journal of medicinal chemistry.

KATP channels modulate GABA release in hippocampal slices in the absence of glucose

I. Margaill, A. Doble, J. Blanchard, 1992, Fundamental & clinical pharmacology.

The role of excitotoxicity in neurodegenerative disease: implications for therapy.

A. Doble, 1999 .

The pharmacology and mechanism of action of riluzole

A. Doble, 1996, Neurology.

Ibotenic acid stimulates d-[3H]aspartate release from cultured cerebellar granule cells

A. Doble, J. Hubert, A. Doble, 1989, Neuroscience Letters.

The mechanism of action of zopiclone

T. Canton, C. Malgouris, A. Doble, 1995, European Psychiatry.

Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.

N. Bowery, A. Hudson, A. Doble, 1981, European journal of pharmacology.

Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity.

A. Imperato, S. Mignani, J. Stutzmann, 2000, Journal of medicinal chemistry.

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

D. Middlemiss, N. Bowery, A. Hudson, 1980, Nature.

Effects of depolarizing stimuli on calcium homeostasis in cultured rat motoneurones

F. Terro, J. Hugon, A. Doble, 1998, British journal of pharmacology.

Differential Effects of Potassium Channel Blockers on Dopamine Release from Rat Striatal Slices

V. Olivier, P. Laduron, A. Doble, 1991, The Journal of pharmacy and pharmacology.

Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: Anatomical and subcellular distribution

A. Basbaum, G. Fur, A. Uzan, 1987, Brain Research Bulletin.

Substance P‐Evoked Calcium Mobilization and Ionic Current Activation in the Human Astrocytoma Cell Line U 373 MG: Pharmacological Characterization

L. Pradier, A. Doble, E. Heuillet, 1993, Journal of neurochemistry.

Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action

J. Glowinski, J. Delumeau, A. Doble, 1994, British journal of pharmacology.

The Gabaa/Benzodiazepine Receptor as a Target for Psychoactive Drugs

I. Martin, A. Doble, 1996 .

Riluzole in Huntington's disease: a 3‐year, randomized controlled study

B. Dubois, H. Przuntek, A. Ludolph, 2007, Annals of neurology.

The METEOR study of diabetes and other metabolic disorders in patients with schizophrenia treated with antipsychotic drugs. I. Methodology

T. Wetterling, M. De Hert, B. Falissard, 2010, International journal of methods in psychiatric research.

Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.

C. Gueremy, A. Doble, J. Malleron, 1991, Journal of medicinal chemistry.

Multiple benzodiazepine receptors: no reason for anxiety.

I. Martin, A. Doble, 1992, Trends in pharmacological sciences.

Vitamin K antagonist treatment in patients with atrial fibrillation and time in therapeutic range in four European countries.

F. Cotté, A. Doble, I. Duprat-Lomon, 2014, Clinical therapeutics.

New Insights Into The Mechanism of Action of Hypnotics

A. Doble, 1999, Journal of psychopharmacology.

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

M. Gurney, E. Hall, A. Doble, 1996, Annals of neurology.

babapenun in a Transgenic Model of ~dd AmyotropfUc Lateral sclerosis

M. Gurney, E. Hall, A. Doble, 1996 .

Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.

G. Böhme, J. Stutzmann, C. Bon, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes.

M. Debono, T. Canton, L. Pradier, 1993, European journal of pharmacology.

The METEOR study: frequency of metabolic disorders in patients with schizophrenia. Focus on first and second generation and level of risk of antipsychotic drugs

T. Wetterling, M. De Hert, B. Falissard, 2011, International clinical psychopharmacology.

Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum

A. Doble, M. Perrier, A. Doble, 1989, Neurochemistry International.

Molecular Cloning, Functional Expression, Pharmacological Characterization and Chromosomal Localization of the Human Metabotropic Glutamate Receptor Type 3

F. Apiou, L. Pradier, A. Doble, 1996, Neuropharmacology.

Burden of disease associated with asthma among the adult general population of five Middle Eastern countries: Results of the SNAPSHOT program.

B. Mahboub, L. Tariq, A. El Hasnaoui, 2018, Respiratory medicine.

Adherence to COPD treatment in Turkey and Saudi Arabia: results of the ADCARE study

L. Tariq, Sarfraz A. Saleemi, A. El Hasnaoui, 2018, International journal of chronic obstructive pulmonary disease.

Neuroprotective effects of riluzole on a model of parkinson's disease in the rat

P. Barnéoud, A. Doble, A. Boireau, 1996, Neuroscience.

Congo red protects against toxicity of beta-amyloid peptides on rat hippocampal neurones.

M. Capet, A Doble, A. Doble, 1994, Neuroreport.

A Rapid Filtration Assay for the Glycine Binding Site on the NMDA Receptor in Rat Cortical Membranes using [3H]Dichlorokynurenic Acid

T. Canton, A. Doble, J. Blanchard, 1992, The Journal of pharmacy and pharmacology.

Photoaffinity labeling of peripheral-type benzodiazepine-binding sites.

G. Le Fur, A. Uzan, C. Renault, 1987, Molecular pharmacology.

Prevalence of asthma among the adult general population of five Middle Eastern countries: results of the SNAPSHOT program

B. Mahboub, L. Tariq, A. El Hasnaoui, 2018, BMC Pulmonary Medicine.

Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. In vitro and ex vivo selectivity profile.

C. Malgouris, A. Doble, F. Flamand, 1993, European journal of pharmacology.

RP 62203, a naphtosultam derivative with potent and selective 5-HT2 antagonist properties III. Autoradiographic studies

P. Laduron, C. Malgouris, A. Doble, 1990 .

The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor.

S. Mignani, G. Néliat, F. Petitet, 1996, European journal of pharmacology.

Baclofen: a selective agonist for a novel type of GABA receptor proceedings.

N. Bowery, A. Hudson, A. Doble, 1979, British journal of pharmacology.

Preferential Decrease in Dopamine Utilization in Prefrontal Cortex by Zopiclone, Diazepam and Zolpidem in Unstressed Rats

A. Doble, J. Blanchard, A. Boireau, 1990, The Journal of pharmacy and pharmacology.

Effects of AMPA receptor modulators on the production of arachidonic acid from striatal neurons.

F. Petitet, A. Doble, J. Blanchard, 1995, European journal of pharmacology.

Pharmacological properties and mechanism of action of the cyclopyrrolones.

J. Stutzmann, A. Doble, J. Blanchard, 1992, L'Encephale.

Application de la lamotrigine dans le traitement du neuro-sida.

A. Bousseau, A. Doble, E. Louvel, 1994 .

APPLICATION D'ANTICONVULSIVANTS COMME LA CARBAMAZEPINE ET l'OXCARBAZEPINE, DANS LE TRAITEMENT DU NEURO-SIDA

A. Bousseau, A. Doble, E. Louvel, 1994 .

Application du riluzole dans le traitement du neuro-sida

A. Bousseau, A. Doble, E. Louvel, 1994 .

The clinical burden of allergic rhinitis in five Middle Eastern countries: results of the SNAPSHOT program

I. Annesi-Maesano, B. Mahboub, L. Tariq, 2018, Allergy, Asthma & Clinical Immunology.

Synthesis and Binding Affinities of Novel Spirocyclic Lactam Peptidomimetics of Somatostatin

R. Labaudinière, S. Mignani, A. Doble, 1998 .

Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®

S. Mignani, Y. Merrer, M. Vuilhorgne, 1996 .

Synthesis and Binding Affinities of Novel Spirocyclic Lactam Peptidomimetics of Somatostatin.

R. Labaudinière, S. Mignani, A. Doble, 1999 .

Design, Synthesis, and Binding Affinities of Novel Non-Peptides Mimics of Somatostatin/Sandostatin.

S. Mignani, Y. Merrer, M. Vuilhorgne, 1996 .

Biochemical and pharmacological characterization of cannabinoid binding sites using [3H]SR141716A

F. Petitet, A Doble, A. Doble, 1996, Neuroreport.

Septide: an agonist for the NK1 receptor acting at a site distinct from substance P.

J. Mayaux, L. Pradier, A. Doble, 1994, Molecular pharmacology.

Comparative Thermodynamics of Benzodiazepine Receptor Ligand Interactions in Rat Neuronal Membranes

A. Doble, 1983, Journal of neurochemistry.

Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex

S. Mignani, J. Stutzmann, J. Randle, 1994 .

Stereoselective inhibition of the binding of [3H]PK 11195 to peripheral-type benzodiazepine binding sites by a quinolinepropanamide derivative.

A. Uzan, C. Renault, M. Dubroeucq, 1986, European journal of pharmacology.

Rate of change in early Huntington's disease: A clinicometric analysis

B. Landwehrmeyer, M. Orth, A. Ludolph, 2012, Movement disorders : official journal of the Movement Disorder Society.

Lack of effect of benzodiazepines on bicuculline‐insensitive GABA‐receptors in the field‐stimulated guinea‐pig vas deferens preparation

A. Doble, M. Turnbull, 1981, The Journal of pharmacy and pharmacology.

Methamphetamine and dopamine neurotoxicity: differential effects of agents interfering with glutamatergic transmission

A. Doble, A. Boireau, F. Bordier, 1995, Neuroscience Letters.

Effects of Non‐NMDA Receptor Modulators on [3H]Dopamine Release from Rat Mesencephalic Cells in Primary Culture

F. Petitet, A. Doble, J. Blanchard, 1995, Journal of neurochemistry.

Benzodiazepine drugs in sleep disorders

D. Nutt, I. Martin, A. Doble, 2020 .

Benzodiazepines as anxiolytics

D. Nutt, I. Martin, A. Doble, 2020 .

Psychometric evaluation of the COPD assessment test: data from the BREATHE study in the Middle East and North Africa region.

C. Nejjari, P. Jones, A. El Hasnaoui, 2012, Respiratory medicine.

Behavioural pharmacology

A. Doble, D. Nutt, I. Martin, 2020, Calming the Brain: Benzodiazepines and related drugs from laboratory to clinic.

Potassium markedly potentiates the effect of veratridine on dopamine release from rat superfused striatal ribbons

V. Olivier, A. Doble, J. Blanchard, 1992, The Journal of pharmacy and pharmacology.

Autoradiographic distribution of [3H]‐suriclone binding sites in the rat brain

C. Malgouris, A. Doble, J. Blanchard, 1995 .

Molecular size of benzodiazepine receptor in rat brain in situ: evidence for a functional dimer?

L. Iversen, A. Doble, 1982, Nature.

EVIDENCE FOR DIFFERENT BINDING DOMAINES ON THE GABAA/BENZODIAZEPINE RECEPTOR FOR BENZODIAZEPINES AND CYCLOPYRROLONES.

T. Canton, A. Doble, 1992 .

Localization of presenilin-1 mRNA in rat brain.

F. Petitet, C. Czech, L. Pradier, 1996, Neuroreport.

A rapid method for reading migration inhibition tests.

A. Doble, 1977, Journal of immunological methods.