C. Harwig

发表

The effect of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild to moderate asthma

P. Barnes, D. Chernoff, B. Leaker, 2013 .

AQX‐1125, small molecule SHIP1 activator inhibits bleomycin‐induced pulmonary fibrosis

S. Cuzzocrea, C. Szabó, T. Genovese, 2017, British journal of pharmacology.

Characterization of AQX‐1125, a small‐molecule SHIP1 activator

C. Szabó, P. Tam, L. Mackenzie, 2013, British journal of pharmacology.

A cofactor approach to copper-dependent catalytic antibodies

K. Janda, K. Nicholas, P. Wentworth, 2002, Proceedings of the National Academy of Sciences of the United States of America.

(18)F-click labeling of a bombesin antagonist with an alkyne-(18)F-ArBF(3) (-): in vivo PET imaging of tumors expressing the GRP-receptor.

F. Bénard, P. Schaffer, Maral Pourghiasian, 2013, American journal of nuclear medicine and molecular imaging.

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

E. De Clercq, D. Schols, G. Bridger, 2011, Bioorganic & medicinal chemistry letters.

Characterization of AQX‐1125, a small‐molecule SHIP1 activator

C. Szabó, D. Chernoff, P. Tam, 2013, British journal of pharmacology.

Taxamycin studies: Synthesis of taxoid-calicheamicin hybrids

S. Py, C. Harwig, S. Banerjee, 1998 .

Taxamycins: a new enediyne family with synthetic and biological potential

C. Harwig, A. G. Fallis, Y. Lu, 1995 .

A one-pot multistep approach to alpha-azido-phosphonate and phosphonothioate diesters: key intermediates in the synthesis of haptens for the generation of antibody ligases.

T. Z. Hoffman, K. Janda, C. Harwig, 2000, Bioorganic & medicinal chemistry letters.

Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice.

C. Overall, S. McCormick, U. auf dem Keller, 2008, Journal of the American Chemical Society.

Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases

C. Overall, P. Schaffer, T. Ruth, 2011 .

Substituent effects on aryltrifluoroborate solvolysis in water: implications for Suzuki-Miyaura coupling and the design of stable (18)F-labeled aryltrifluoroborates for use in PET imaging.

T. Ruth, Richard Ting, D. Perrin, 2008, The Journal of organic chemistry.

Synthesis and characterization of 2,6-difluoro-4-carboxyphenylboronic acid and a biotin derivative thereof as captors of anionic aqueous [18F]-fluoride for the preparation of [18F/19F]-labeled aryltrifluoroborates with high kinetic stability

T. Ruth, Richard Ting, D. Perrin, 2008 .

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.

E. De Clercq, D. Schols, G. Bridger, 2011, Bioorganic & medicinal chemistry letters.

AMD070, a CXCR4 Chemokine Receptor Antagonist: Practical Large-Scale Laboratory Synthesis

Gang Chen, G. Bridger, B. Carpenter, 2008 .

Organometallic reagents and protocols for synthesis

Simon S. Woo, S. Py, P. Forgione, 2000 .

Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: implications for an alternative enediyne therapeutic mechanism.

R. Lerner, S. Py, A. Simeonov, 2001, Journal of the American Chemical Society.

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Dominique Schols, E. De Clercq, D. Schols, 2010, Journal of medicinal chemistry.

Synthesis of SHIP1‐Activating Analogs of the Sponge Meroterpenoid Pelorol

R. Andersen, A. Mui, G. Krystal, 2012 .

Taxamycin Studies: CrCl(2)/NiCl(2)-Mediated Cyclizations and Unusual SeO(2) Oxidations.

S. Py, C. Harwig, A. G. Fallis, 1997, The Journal of organic chemistry.

Unexpected 1,3-oxazolidine formation in the attempted oxidation of N-aryl-N-methyl substituted β-amino alcohols using pyridinium dichromate

K. Janda, J. Yli-Kauhaluoma, P. Wentworth, 1998 .

Unexpected 1,3-Oxazolidine Formation in the Attempted Oxidation of N-Aryl-N-methyl Substituted β-Amino Alcohols Using Pyridinium Dichromate.

K. Janda, J. Yli-Kauhaluoma, P. Wentworth, 1998 .

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

G. Lenz, G. Packham, M. Cragg, 2019, Clinical Cancer Research.

Taxamycins : a new enediyne family constructed from versatile disilyl-substituted building blocks

C. Harwig, A. G. Fallis, Y. Lu, 1993 .

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

F. Bénard, S. Dedhar, R. Kappelhoff, 2010, Cancer research.

Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

G. Packham, M. Cragg, F. Stevenson, 2016 .

Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

D. Schols, S. Fricker, G. Bridger, 2011, Journal of the American Chemical Society.

Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.

D. Schols, R. Wong, S. Fricker, 2012, ACS medicinal chemistry letters.