H. Machelska

发表

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

Marcus Weber, A. Rodríguez-Gaztelumendi, C. Stein, 2018, Scientific Reports.

Skin-nerve preparation to assay the function of opioid receptors in peripheral endings of sensory neurons.

H. Machelska, R. Moshourab, Y. Schmidt, 2015, Methods in molecular biology.

A stomatin-domain protein essential for touch sensation in the mouse

Rabih Moshourab, Gary R. Lewin, D. Riethmacher, 2007, Nature.

Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats

A. Coenen, R. Przewłocki, W. Lasoń, 1995, Neuroscience Letters.

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

C. Stein, H. Machelska, 2011, Pharmacological Reviews.

Co-expression of β-endorphin with adhesion molecules in a model of inflammatory pain

C. Stein, S. Mousa, M. Schäfer, 2000, Journal of Neuroimmunology.

Peripheral analgesic and antiinflammatory effects of opioids

C. Stein, M. Schäfer, H. Machelska, 2001, Zeitschrift für Rheumatologie.

Opioid Peptide–expressing Leukocytes: Identification, Recruitment, and Simultaneously Increasing Inhibition of Inflammatory Pain

H. Rittner, A. Brack, C. Stein, 2001, Anesthesiology.

Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain

C. Stein, S. Mousa, M. Schäfer, 2002, Journal of Neuroimmunology.

Opioid Control of Inflammatory Pain Regulated by Intercellular Adhesion Molecule-1

H. Rittner, A. Brack, C. Stein, 2002, The Journal of Neuroscience.

Different mechanisms of intrinsic pain inhibition in early and late inflammation

C. Stein, S. Mousa, M. Schäfer, 2003, Journal of Neuroimmunology.

Tissue Monocytes/Macrophages in Inflammation: Hyperalgesia versus Opioid-mediated Peripheral Antinociception

R. Reszka, H. Rittner, A. Brack, 2004, Anesthesiology.

Selectins and integrins but not platelet–endothelial cell adhesion molecule‐1 regulate opioid inhibition of inflammatory pain

H. Rittner, A. Brack, C. Stein, 2004, British journal of pharmacology.

Peripheral Antinociceptive Effects of Exogenous and Immune Cell-Derived Endomorphins in Prolonged Inflammatory Pain

H. Rittner, S. Berger, B. Przewłocka, 2006, The Journal of Neuroscience.

Targeting of opioid-producing leukocytes for pain control

H. Machelska, 2007, Neuropeptides.

Breaking the pain barrier

P. Heppenstall, C. Stein, H. Machelska, 2003, Nature Medicine.

Immunohistochemical Analysis of Opioid Receptors in Peripheral Tissues.

H. Machelska, Y. Schmidt, 2020, Methods in molecular biology.

Immunohistochemical analysis of opioid receptors in peripheral tissues.

H. Machelska, Y. Schmidt, 2015, Methods in molecular biology.

A nontoxic pain killer designed by modeling of pathological receptor conformations

V. Durmaz, A. Rodríguez-Gaztelumendi, C. Stein, 2017, Science.

Interleukin-4 Induces the Release of Opioid Peptides from M1 Macrophages in Pathological Pain

D. Labuz, H. Machelska, M. Celik, 2021, The Journal of Neuroscience.

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

B. Siegmund, D. Labuz, H. Machelska, 2016, Journal of Neuroinflammation.

Stronger Antinociceptive Efficacy of Opioids at the Injured Nerve Trunk Than at Its Peripheral Terminals in Neuropathic Pain

D. Labuz, H. Machelska, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons – Effects of Nerve Injury

V. Spahn, D. Labuz, H. Machelska, 2018, Front. Pharmacol..

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice

P. Reddanna, K. Weylandt, L. Wieler, 2021, Metabolites.

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

H. Machelska, M. Celik, 2020, Frontiers in Immunology.

Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study.

R. Przewłocki, B. Przewłocka, S. Mousa, 2009, Pharmacological reports : PR.

IL-4 induces M2 macrophages to produce sustained analgesia via opioids.

R. Glauben, D. Labuz, H. Machelska, 2020, JCI insight.

Intracerebroventricular galanin and N-terminal galanin fragment enhance the morphine-induced analgesia in the rat

R. Przewłocki, G. Kupryszewski, B. Przewłocka, 2005, Journal of Neural Transmission / General Section JNT.

Immune cell-derived opioids protect against neuropathic pain in mice.

H. Rittner, S. Mousa, A. Schreiter, 2009, The Journal of clinical investigation.

A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

C. Stein, H. Machelska, Sara González-Rodríguez, 2020, Scientific Reports.

Leukocyte-Derived Opioid Peptides and Inhibition of Pain

C. Stein, H. Machelska, 2006, Journal of Neuroimmune Pharmacology.

Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

H. Machelska, R. Negrete, M. Celik, 2022, Scientific reports.

pKa of opioid ligands as a discriminating factor for side effects

Marcus Weber, A. Rodríguez-Gaztelumendi, C. Stein, 2019, Scientific Reports.

Leukocyte opioid receptors mediate analgesia via Ca2+-regulated release of opioid peptides

C. Gaveriaux-Ruff, B. Kieffer, A. Zimmer, 2016, Brain, Behavior, and Immunity.

Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

A. Zimmer, D. Labuz, H. Machelska, 2016, Scientific Reports.

μ-Opioid Receptor Antibody Reveals Tissue-Dependent Specific Staining and Increased Neuronal μ-Receptor Immunoreactivity at the Injured Nerve Trunk in Mice

C. Gaveriaux-Ruff, H. Machelska, Y. Schmidt, 2013, PloS one.

Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

R. Przewłocki, B. Przewłocka, H. Machelska, 1994, Neuropharmacology.

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

B. Roques, M. Fournié-Zaluski, C. Stein, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury

A. Brack, A. Schreiter, D. Labuz, 2010, Brain, Behavior, and Immunity.

Leukocytes in the regulation of pain and analgesia

H. Rittner, C. Stein, H. Machelska, 2005, Journal of leukocyte biology.

Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse

W. Lasoń, B. Przewłocka, H. Machelska, 1994, European Neuropsychopharmacology.

Attacking pain at its source: new perspectives on opioids

C. Stein, M. Schäfer, H. Machelska, 2003, Nature Medicine.

Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain

M. Schroff, B. Wittig, H. Rittner, 2009, Molecular pain.

CHAPTER 6 – Immune-derived Opioids: Production and Function in Inflammatory Pain

C. Stein, H. Machelska, 2007 .

Immune Mechanisms in Pain Control

C. Stein, H. Machelska, 2002, Anesthesia and analgesia.

Analgesic and Antiinflammatory Effects of Two Novel &kgr;-Opioid Peptides

P. Rivière, J. Junien, C. Stein, 2001, Anesthesiology.

Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.

R. Przewłocki, B. Przewłocka, D. Labuz, 1997, The Journal of pharmacology and experimental therapeutics.

Peripheral Opioid Analgesia Neuroimmune Interactions and Therapeutic Implications

C. Stein, H. Machelska, 2003 .

Analysis of potassium and calcium imaging to assay the function of opioid receptors.

V. Spahn, H. Machelska, Dinah Nockemann, 2015, Methods in molecular biology.

Intrathecal Oxotremorine Affects Formalin-Induced Behavior and Spinal Nitric Oxide Synthase Immunoreactivity in Rats

B. Przewłocka, F. Pavone, F. Capone, 1999, Pharmacology Biochemistry and Behavior.

Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide

B. Przewłocka, F. Pavone, F. Capone, 1999, European Neuropsychopharmacology.

Immune cell-mediated opioid analgesia.

H. Machelska, M. Celik, 2020, Immunology letters.

Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans.

C. Stein, H. Machelska, R. Dehaven, 1999, The Journal of pharmacology and experimental therapeutics.

Peripheral Effects of the k-Opioid Agonist EMD 61753 on Pain and Inflammation in Rats and Humans

C. Stein, H. Machelska, R. Dehaven, 1999 .

Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

P. Heppenstall, D. Labuz, H. Machelska, 2012, Molecular pain.

Opioids and TRPV1 in the peripheral control of neuropathic pain – Defining a target site in the injured nerve

V. Spahn, D. Labuz, H. Machelska, 2016, Neuropharmacology.

Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord.

R. Przewłocki, B. Przewłocka, H. Machelska, 1993, Life sciences.

Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: a search for selectivity of delta receptor subtypes

R. Przewłocki, B. Przewłocka, D. Labuz, 1998, Neuropeptides.

Relative contribution of peripheral versus central opioid receptors to antinociception

C. Stein, S. Mousa, M. Schäfer, 2007, Brain Research.

Control of neuropathic pain by immune cells and opioids.

H. Machelska, 2011, CNS & neurological disorders drug targets.

Dual Peripheral Actions of Immune Cells in Neuropathic Pain

H. Machelska, 2011, Archivum Immunologiae et Therapiae Experimentalis.

Differential effects of intrathecally and intracerebroventricularly administered nitric oxide donors on noxious mechanical and thermal stimulation.

M. Radomski, R. Przewłocki, B. Przewłocka, 1998, Polish journal of pharmacology.

Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics

H. Machelska, M. Celik, 2016, F1000Research.

Open Peer Review

H. Machelska, M. Celik, 2022 .

Advances in Achieving Opioid Analgesia Without Side Effects

H. Machelska, M. Celik, 2018, Front. Pharmacol..

Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells

H. Rittner, A. Brack, C. Stein, 2004, Pain.

Mobilization of Opioid-containing Polymorphonuclear Cells by Hematopoietic Growth Factors and Influence on Inflammatory Pain

H. Rittner, A. Brack, C. Stein, 2004, Anesthesiology.

Peripheral analgesic and anti-inflammatory effects of opioids — neuro-immune crosstalk

C. Stein, H. Machelska, 2003 .

Immune mechanisms of pain and analgesia

C. Stein, H. Machelska, 2003 .

Pain control in inflammation governed by selectins

P. Cabot, C. Stein, S. Mousa, 1998, Nature Medicine.

Real-Time Quantitative Reverse Transcription PCR for Detection of Opioid Receptors in Immune Cells.

D. Labuz, H. Machelska, M. Celik, 2020, Methods in molecular biology.

Impaired Nociception and Peripheral Opioid Antinociception in Mice Lacking Both Kinin B1 and B2 Receptors

M. Bader, C. Stein, M. Schäfer, 2012, Anesthesiology.

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

R. Haag, Xuejiao Zhang, M. Parr, 2017, eLife.

Why is morphine not the ultimate analgesic and what can be done to improve it?

C. Stein, M. Schäfer, H. Machelska, 2000, The journal of pain : official journal of the American Pain Society.

Effects of pentylenetetrazol kindling on glutamate receptor genes expression in the rat hippocampus

R. Przewłocki, W. Lasoń, J. Turchan, 1998, Brain Research.

Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

B. Ziółkowska, R. Przewłocki, B. Przewłocka, 1997, Neuroreport.

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

B. Siegmund, D. Labuz, H. Machelska, 2016, Journal of Neuroinflammation.

Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

A. Rodríguez-Gaztelumendi, C. Stein, V. Spahn, 2018, Pain.

Peripheral opioid analgesia.

C. Stein, M. Schäfer, H. Machelska, 2003, Current pharmaceutical biotechnology.

Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis.

V. Sunkara, J. Temp, D. Labuz, 2019, Osteoarthritis and cartilage.

Tailor‐Made Core‐Multishell Nanocarriers for the Delivery of Cationic Analgesics to Inflamed Tissue

R. Haag, R. Netz, C. Stein, 2019, Advanced Therapeutics.

Effects of pilocarpine and kainate-induced seizures on N-methyl-d-aspartate receptor gene expression in the rat hippocampus

R. Przewłocki, W. Lasoń, J. Turchan, 1997, Neuroscience.

The effects of cocaine-induced seizures on the proenkephalin mRNA level in the mouse hippocampus: A possible involvement of the nitric oxide pathway

R. Przewłocki, W. Lasoń, B. Przewłocka, 1994, Neuroscience Letters.

Patch Clamp Analysis of Opioid-Induced Kir3 Currents in Mouse Peripheral Sensory Neurons Following Nerve Injury.

D. Labuz, H. Machelska, Philip Stötzner, 2021, Methods in molecular biology.

Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain.

C. Stein, J. Temp, H. Machelska, 2020, Pain.

Pain Control by Immune‐Derived Opioids

C. Stein, H. Machelska, 2000, Clinical and experimental pharmacology & physiology.

Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression

H. Rittner, A. Brack, C. Stein, 2004, Pain.

Immune System, Pain and Analgesia

H. Rittner, C. Stein, H. Machelska, 2020, The Senses: A Comprehensive Reference.

286 PAIN CONTROL BY PREVENTION OF OPIOID PEPTIDE DEGRADATION IN PERIPHERAL INFLAMED TISSUE

C. Stein, A. Schreiter, H. Machelska, 2009 .

Peripheral Neuroimmune Interactions and Neuropathic Pain

H. Machelska, 2014 .

Pain control and the immune system

C. Stein, H. Machelska, 1999 .

Peripheral Nociceptive Integration

C. Stein, H. Machelska, 1998 .

Involvement of the nitric oxide pathway in nociceptive processes in the central nervous system in rats

H. Machelska, B. Przewklocka, R. Przewklocki, 1994, Regulatory Peptides.

Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund’s adjuvant-induced paw inflammation model

K. Weylandt, H. Kuhn, D. Heydeck, 2023, Inflammation Research.

Stronger Antinociceptive Efficacy of Opioids at the Injured Nerve Trunk Than at Its Peripheral Terminals in Neuropathic Pain

D. Labuz, H. Machelska, 2013, Journal of Pharmacology and Experimental Therapeutics.

Functional evidence of pain control by the immune system.

H. Machelska, 2003, Advances in Experimental Medicine and Biology.

Comment on “Neutrophils: are they hyperalgesic or anti‐hyperalgesic?”

H. Rittner, A. Brack, C. Stein, 2006, Journal of leukocyte biology.

Nitric oxide synthase inhibitor l-name prevents amphetamine-induced prodynorphin gene expression in the rat

W. Lasoń, J. Turchan, B. Przewłocka, 1996, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Opioids and TRPV1 in the peripheral control of neuropathic pain – Defining a target site in the injured nerve

D. Labuz, H. Machelska, M. Celik, 2016, Neuropharmacology.

Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

H. Kuhn, M. Rothe, G. Püschel, 2023, International journal of molecular sciences.