M. Perry

发表

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

Synthetic FKBP12 ligands. Design and synthesis of pyranose replacements.

S. Teague, M. Perry, Michael J. Stocks, 1994 .

The discovery of CCR3/H1 dual antagonists with reduced hERG risk.

B. Springthorpe, P. Barton, R. Riley, 2012, Bioorganic & medicinal chemistry letters.

Surprising lipophilicity observations identify unexpected conformational effects.

U. Börjesson, C. Tyrchan, M. Perry, 2022, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of MEK PROTACs.

M. Perry, D. Cunoosamy, S. Vollmer, 2019, Journal of medicinal chemistry.

A class of highly selective inhibitors bind to an active state of PI3Kγ

Roger L. Williams, G. Dahl, M. Wymann, 2019, Nature Chemical Biology.

14-3-3 Modulation of the Inflammatory Response.

C. Ottmann, M. Perry, C. Munier, 2020, Pharmacological research.

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.

M. Perry, B. Valastro, Matthew J. Thomas, 2019, Journal of medicinal chemistry.

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.

H. Lindmark, C. Tyrchan, K. Björhall, 2017, Journal of medicinal chemistry.

Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.

A. Davis, D. Ferguson, L. Kingston, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors.

H. Lindmark, C. Tyrchan, N. Holden, 2018, Journal of medicinal chemistry.

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

C. Ottmann, L. De Maria, L. Brunsveld, 2021, The Journal of biological chemistry.

Pyridazines and Their Benzo Derivatives

M. Perry, Yiqing Feng, G. Chinigo, 2021 .

A Synthesis of the C24-C34 Segment of FK 506

M. Perry, P. Kocieňski, Michael J. Stocks, 1990 .

Designing novel building blocks is an overlooked strategy to improve compound quality.

Matthew W D Perry, Thierry Kogej, Frederick W Goldberg, 2015, Drug discovery today.

Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.

Matthew W D Perry, Timothy Gallagher, C. Hirschhäuser, 2012, Organic letters.

Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.

Matthew W D Perry, Emma Roe, Robert J Riley, 2012, Bioorganic & medicinal chemistry letters.

Azo anions in systhesis. pt 1. t-butylhydrazones as acyl-anion equivalents

J. Baldwin, J. Bottaro, M. Perry, 1986 .

Azo anions in synthesis : Use of trityl- and diphenyl-4-pyridylmethylhydrazones for reductive C-C bond formation

J. Baldwin, M. Perry, J. Kolhe, 1986 .

Applications of the thermal ene reaction of aldehyde t-butyl- and phenyl-hydrazones

J. Baldwin, M. Perry, J. Kolhe, 1986 .

Michael additions of hydrazones for carbon–carbon bond formation

J. Baldwin, J. Bottaro, M. Perry, 1984 .

Stereocontrol during the alkylation of enolates attached to .pi.-allyl-Mo(CO)2Cp systems

S. Mallik, W. Youngs, M. Perry, 1990 .

Synthesis and reactions of η3-5-oxocyclohexenyl(dicarbonyl)(η5-cyclopentadienyl)molybdenum

M. Perry, A. J. Pearson, 1989 .

PI3K inhibitors are finally coming of age

K. Okkenhaug, F. André, B. Vanhaesebroeck, 2021, Nature Reviews Drug Discovery.

Asymmetric Reduction of Lactam-Based β-Aminoacrylates. Synthesis of Heterocyclic β(2)-Amino Acids.

T. Gallagher, M. Perry, H. Campello, 2016, Organic letters.

Monocarboxylate transporter MCT1 is a target for immunosuppression

A. Ross, Leslie R Evans, A. Jackson, 2005, Nature chemical biology.

Stabilization of protein-protein interactions in drug discovery

Michael Hann, Matthew W D Perry, Christian Ottmann, 2017, Expert opinion on drug discovery.

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction

C. Ottmann, Andrew J. Wilson, A. Gunnarsson, 2022, Journal of medicinal chemistry.

Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors.

H. Lindmark, C. Tyrchan, M. Perry, 2017, Bioorganic & medicinal chemistry letters.

Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

H. Lindmark, U. Börjesson, C. Tyrchan, 2021, Journal of medicinal chemistry.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

Author Correction: PI3K inhibitors are finally coming of age

K. Okkenhaug, B. Vanhaesebroeck, Jennifer R. Brown, 2021, Nature reviews. Drug discovery.

One-Pot, Three-Component Copper-Catalysed ‘Click’ TriazoleSynthesis Utilising the Inexpensive, Shelf-Stable DiazotransferReagent Imidazole-1-sulfonyl Azide Hydrochloride

R. Jewell, M. Perry, Michael J. Stocks, 2009 .

The Role of Allylic Strain for Conformational Control in Medicinal Chemistry.

C. Tyrchan, Hongtao Zhao, M. Perry, 2023, Journal of medicinal chemistry.

A Practical Method for Targeted Library Design Balancing Lead‐like Properties with Diversity

Garry Pairaudeau, Michael J Stocks, Gareth R H Wilden, 2009, ChemMedChem.

Identification of phosphate-containing compounds as new inhibitors of 14-3-3/c-Abl protein-protein interaction.

A. Angelucci, M. Botta, M. Mori, 2020, ACS Chemical Biology.

Surprising lipophilicity observations identify unexpected conformational effects.

U. Börjesson, C. Tyrchan, M. Perry, 2022, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.

H. Lindmark, C. Tyrchan, K. Björhall, 2017, Journal of medicinal chemistry.

Discovery of small molecule human FPR1 receptor antagonists.

J. Unitt, R. Weaver, A. Baxter, 2009, Bioorganic & medicinal chemistry letters.