J. Berke

发表

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

Peggy Geluykens, M. Van Loock, B. Devogelaere, 2017, Antiviral research.

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

M. Cummings, B. Devogelaere, F. Pauwels, 2010, Journal of Virology.

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

M. Cummings, R. Clayton, B. Devogelaere, 2012, Antimicrobial Agents and Chemotherapy.

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

B. Samuelsson, S. Eriksson, L. Leclercq, 2011, Antimicrobial Agents and Chemotherapy.

Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle

F. Zoulim, F. Pauwels, D. Durantel, 2018, Antimicrobial Agents and Chemotherapy.

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Bioorganic & medicinal chemistry letters.

Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202).

M. Cummings, Christophe Moreno, M. Peeters, 2013, Journal of hepatology.

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

B. Samuelsson, Lili Hu, L. Leclercq, 2014, Journal of medicinal chemistry.

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

M. Cummings, B. Devogelaere, Lili Hu, 2014, Journal of medicinal chemistry.

Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures.

Emmanuel Gustin, F. Pauwels, D. Peeters, 2021, Journal of virological methods.

Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379

F. Pauwels, Karen Vergauwen, K. Vandyck, 2020, Antimicrobial Agents and Chemotherapy.

Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus

Ellen Van Damme, F. Pauwels, Karen Vergauwen, 2017, Antimicrobial Agents and Chemotherapy.

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).

Bing Huang, Ann Vos, Karen Vergauwen, 2018, Journal of medicinal chemistry.

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

L. Vrang, M. Cummings, Herman A de Kock, 2010, Antimicrobial Agents and Chemotherapy.

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

B. Samuelsson, M. Cummings, Christophe Buyck, 2010, Journal of medicinal chemistry.

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.

L. Leclercq, T. Jonckers, J. Snoeys, 2016, Journal of medicinal chemistry.

Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.

J. Neefs, E. Jacoby, O. Lenz, 2020, The Journal of antimicrobial chemotherapy.

Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects

W. Talloen, J. Biewenga, J. Snoeys, 2019, Advances in Therapy.

Virology analysis of chronic hepatitis B virus–infected patients treated for 28 days with JNJ‐56136379 monotherapy

W. Talloen, O. Lenz, T. Verbinnen, 2020, Journal of viral hepatitis.

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

B. Meier, M. Nassal, A. Böckmann, 2019, Front. Mol. Biosci..

Antiviral profiling of the capsid assembly modulator BAY41‐4109 on full‐length HBV genotype A‐H clinical isolates and core site‐directed mutants in vitro

F. Pauwels, Ann Vos, O. Lenz, 2017, Antiviral research.

Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1

Sabina Hernandez Penna, D. Moradpour, M. Heim, 2005, Journal of Virology.

Suppression of short interfering RNA-mediated gene silencing by the structural proteins of hepatitis C virus.

D. Moradpour, M. Wernli, P. Erb, 2008, The Journal of general virology.

Short Communication Suppression of short interfering RNA-mediated gene silencing by the structural proteins of hepatitis C virus

D. Moradpour, M. Wernli, P. Erb, 2008 .

Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex

Volker Brass, Darius Moradpour, François Penin, 2008, Proceedings of the National Academy of Sciences.

Antiviral activity and mode of action of TMC 647078 , a novel 1 nucleoside inhibitor of the HCV NS 5 B polymerase 2 Running title : Characterization of HCV nucleoside inhibitor TMC 647078 3 4

B. Samuelsson, S. Eriksson, L. Leclercq, 2011 .

Hepatitis C virus comes full circle: Production of recombinant infectious virus in tissue culture

D. Moradpour, J. Berke, 2005, Hepatology.

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.

J. Tavernier, S. Lievens, R. Clayton, 2012, Methods in molecular biology.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.

Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex.

F. Pauwels, E. Krausz, D. Fenistein, 2010, Journal of virological methods.

Characterization of Nonstructural Protein Membrane Anchor Deletion Mutants Expressed in the Context of the Hepatitis C Virus Polyprotein

H. Blum, D. Moradpour, R. Gosert, 2005, Journal of Virology.

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.

M. Cummings, Lili Hu, O. Nyanguile, 2012, Bioorganic & medicinal chemistry letters.

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR

B. Meier, M. Nassal, D. Durantel, 2022, bioRxiv.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

B. Samuelsson, S. Eriksson, L. Leclercq, 2011, Antimicrobial Agents and Chemotherapy.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

J. Berke, Sarah Sauviller, Ying Tan, 2023, bioRxiv.