K. Stefanski

发表

Enhanced Oral Bioavailability of a Poorly Water Soluble Drug PNU‐91325 by Supersaturatable Formulations

Ping Gao, P. Gao, Tiehua Huang, 2004, Drug development and industrial pharmacy.

Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance.

Kimberly A. Foster, M. Hussain, Chengyu Liu, 2018, Journal of pharmaceutical sciences.

Drug-polymer-water interaction and its implication for the dissolution performance of amorphous solid dispersions.

M. Hussain, Chengyu Liu, M. Hageman, 2015, Molecular pharmaceutics.

Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration

Kimberly A. Foster, C. Gesenberg, K. Stefanski, 2021, Pharmaceutical Research.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

G. Trainor, A. Mathur, D. Langley, 2009, Journal of medicinal chemistry.

Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction

M. Hussain, Chengyu Liu, M. Hageman, 2016, Pharmaceutical Research.

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.

Kimberly A. Foster, J. Fargnoli, J. Hunt, 2021, ACS medicinal chemistry letters.

Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization.

Michael G. Yang, D. Shuster, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.

R. Talbott, R. Borzilleri, T. Olah, 2016, Bioanalysis.

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.

C. Weigelt, M. Poss, J. Sack, 2016, Bioorganic & medicinal chemistry letters.

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Journal of medicinal chemistry.

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

C. Weigelt, M. Poss, J. Sack, 2017, Bioorganic & medicinal chemistry letters.

Enhanced aqueous dissolution of hydrophobic apixaban via direct incorporation of hydrophilic nanographene oxide.

Kimberly A. Foster, S. Mitra, K. Stefanski, 2022, Colloids and surfaces. B, Biointerfaces.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.

D. Rohrer, F. Schwende, B. Rush, 2007, Bioorganic & medicinal chemistry letters.

Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.

M. Hussain, Chengyu Liu, M. Hageman, 2016, Molecular pharmaceutics.

Potassium channel conductance: a mechanism affecting hair growth both in vitro and in vivo.

M. Brunden, M. Kubicek, A. Buhl, 1992, The Journal of investigative dermatology.

Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.

Joel Morris, D. B. Evans, S. Sharma, 1996, Journal of medicinal chemistry.

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, ACS medicinal chemistry letters.

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction

M. Hussain, Chengyu Liu, M. Hageman, 2016, Pharmaceutical Research.

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

J. Tokarski, G. Trainor, A. Mathur, 2015, ACS medicinal chemistry letters.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Oral delivery of highly lipophilic poorly water-soluble drugs: spray-dried dispersions to improve oral absorption and enable high-dose toxicology studies of a P2Y1 antagonist.

P. Lam, Christine S. Huang, M. Hageman, 2014, Journal of pharmaceutical sciences.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, Journal of medicinal chemistry.

Local topical delivery of drugs: a model incorporating simultaneous diffusion and metabolic interconversion between drug and a single metabolite in the skin.

N. Ho, K. Stefanski, C. Barsuhn, 1989, Journal of Theoretical Biology.

Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate

Kimberly A. Foster, S. Mitra, K. Stefanski, 2021, Molecules.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.