Yen-Shan Chen

发表

New Horizons: Next-Generation Insulin Analogs: Structural Principles and Clinical Goals.

M. Weiss, Deepak Chatterjee, M. Jarosinski, 2021, The Journal of clinical endocrinology and metabolism.

Mammalian Testis-determining Factor SRY and the Enigma of Inherited Human Sex Reversal

E. Haas, M. Weiss, N. Phillips, 2011, The Journal of Biological Chemistry.

“Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution

Brian J. Smith, F. Ismail-Beigi, P. Arvan, 2020, The Journal of Biological Chemistry.

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights Distinction between External and Internal Diselenide Bridges.

F. Ismail-Beigi, M. Weiss, N. Rege, 2020, Chemistry.

Human Sex Determination at the Edge of Ambiguity

M. Weiss, N. Phillips, Yen-Shan Chen, 2016, The Journal of Biological Chemistry.

Mutation-Driven Evolution: Microsatellite Instability Drives Speciation in a Mammalian Taxon

M. Weiss, Yen-Shan Chen, Paul W Sequeira, 2015 .

Structure-Function Relationships in Human Testis-determining Factor SRY

M. Weiss, N. Phillips, Nalinda P. Wickramasinghe, 2014, The Journal of Biological Chemistry.

Stabilization of a Protein by a Single Halogen-Based Aromatic Amplifier

F. Ismail-Beigi, M. Meuwly, Krystel El Hage, 2022, bioRxiv.

CHARACTERIZATION OF TWO MAJOR FAMILIES OF FIBRINOGENOLYTIC PROTEASES FROM THE VENOM OF TAIWAN HABU WITH SPECIAL REFERENCE TO THEIR MEDICAL APPLICATIONS

S. Chiou, Yen-Shan Chen, 2005 .

Characterization and molecular cloning of one novel C-type lectin from the venom of Taiwan habu (Trimeresurus mucrosquamatus).

Chun-Hao Huang, S. Chiou, Yen-Shan Chen, 2010, Toxicon : official journal of the International Society on Toxinology.

Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity

E. Haas, M. Georgiadis, M. Weiss, 2022, Frontiers in Endocrinology.

Sesamin suppresses macrophage-derived chemokine expression in human monocytes via epigenetic regulation.

C. Hsieh, Hsuan-Fu Kuo, C. Hung, 2014, Food & function.

Genetic, Genomic and Biophysical Case Study: Familial 46, XY Sex Reversal due to a Novel Inherited Mutation in Human Testis-Determining Factor SRY

M. Weiss, A. Belgorosky, Deepak Chatterjee, 2021, bioRxiv.

Inherited Human Sex Reversal due to Loss of a Water-Mediated Hydrogen Bond at a Conserved Protein-DNA Interface

E. Haas, D. Amir, M. Weiss, 2021, bioRxiv.

Generation and mutational analysis of a transgenic mouse model of human SRY

A. Sinclair, M. Weiss, P. Koopman, 2021, bioRxiv.

Inherited Sex-Reversal Mutations in SRY Define a Functional Threshold of Gonadogenesis: Biochemical and Evolutionary Implications of a Rare Monogenic Syndrome

M. Weiss, Yen-Shan Chen, J. Racca, 2015 .

Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold

M. Weiss, N. Phillips, Yen-Shan Chen, 2013, Proceedings of the National Academy of Sciences.

Structural principles of insulin formulation and analog design: A century of innovation

M. Weiss, Deepak Chatterjee, M. Jarosinski, 2021, Molecular metabolism.

Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty

M. Weiss, N. Phillips, Yen-Shan Chen, 2013, Proceedings of the National Academy of Sciences.

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

F. Ismail-Beigi, M. Lawrence, M. Weiss, 2017, The Journal of Biological Chemistry.

Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity

M. Weiss, Yen-Shan Chen, J. Racca, 2022, Frontiers in Endocrinology.

Human Sex Determination at the Edge of Ambiguity

M. Weiss, N. Phillips, Yen-Shan Chen, 2016, The Journal of Biological Chemistry.

Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications

R. DiMarchi, M. Weiss, Michael D. Glidden, 2022, Frontiers in Endocrinology.

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

F. Ismail-Beigi, R. DiMarchi, M. Weiss, 2022, Frontiers in Endocrinology.

Evolution of insulin at the edge of foldability and its medical implications

F. Ismail-Beigi, P. Arvan, M. Weiss, 2020, Proceedings of the National Academy of Sciences.

Structural Lessons From the Mutant Proinsulin Syndrome

M. Weiss, Deepak Chatterjee, Yen-Shan Chen, 2021, Frontiers in Endocrinology.

Diabetes Mellitus due to Toxic Misfolding of Proinsulin Variants.

M. Weiss, Deepak Chatterjee, Yen-Shan Chen, 2021, Molecular metabolism.

MAMMALIAN TESTIS-DETERMINING FACTOR SRY HAS EVOLVED TO THE EDGE OF AMBIGUITY

Yen-Shan Chen, 2013 .

Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

M. Lawrence, Yule Liu, T. Hattier, 2021, Proceedings of the National Academy of Sciences.

Prevalence and risk factors for feeding and swallowing difficulties in spinal muscular atrophy types II and III.

Y. Jong, Tai-Heng Chen, Yen-Shan Chen, 2012, The Journal of pediatrics.

Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability

F. Ismail-Beigi, P. Arvan, M. Weiss, 2021, bioRxiv.

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

M. Weiss, Yen-Shan Chen, Balamurugan Dhayalan, 2023, bioRxiv.

1 SRY and the Enigma of Inherited Human Sex Reversal FRUSTRATED INDUCED FIT IN A BENT PROTEIN-DNA COMPLEX

E. Haas, M. Weiss, N. Phillips, 2011 .

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

F. Ismail-Beigi, M. Lawrence, M. Weiss, 2017, Journal of Biological Chemistry.