J. Vennerstrom

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Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target

S. Almahmoud, Xiaofang Wang, J. Vennerstrom, 2019, Molecules.

Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides.

M. Kaiser, Yuxiang Dong, Xiaofang Wang, 2015, ACS infectious diseases.

Activity of diimidazoline amides against African trypanosomiasis.

M. Kaiser, Yuxiang Dong, Xiaofang Wang, 2014, Bioorganic & medicinal chemistry letters.

Haematin (haem) polymerization and its inhibition by quinoline antimalarials

J. Vennerstrom, A. Dorn, S. Vippagunta, 1997 .

Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria.

L. Gerena, W. Milhous, J. Vennerstrom, 1992, Journal of medicinal chemistry.

Meeting Report Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications

R. Hallett, T. Wellems, J. Breman, 2012 .

Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.

J. Karle, H. Matile, A. Bhattacharjee, 1999, Journal of medicinal chemistry.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Rick Gussio, Sina Bavari, E. Sausville, 2003, Biochemical and biophysical research communications.

Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore

P. Wipf, R. Gussio, S. Bavari, 2008, ChemMedChem.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

D. Zaharevitz, R. Gussio, K. Kodukula, 2005, Bioorganic & medicinal chemistry.

Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.

L. Gerena, W. Milhous, J. Vennerstrom, 1998, Journal of medicinal chemistry.

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

S. Xiao, J. Xue, Yuxiang Dong, 2014, Parasitology Research.

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

J. Keiser, J. Chollet, Y. Alnouti, 2010, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species

M. Tanner, J. Utzinger, J. Keiser, 2007, Antimicrobial Agents and Chemotherapy.

Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67.

Nicholas Y. Palermo, D. Ronning, Joseph A. Vetro, 2020, ACS infectious diseases.

In Vivo Activity of Aryl Ozonides against Schistosoma Species

J. Keiser, J. Chollet, Yuxiang Dong, 2011, Antimicrobial Agents and Chemotherapy.

Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery Edited by P. J. Rosenthal. Humana Press, Totowa, NJ. 2001. xi + 396 pp. 18 × 26 cm. ISBN 0-89603-670-7. $135.00.

J. Vennerstrom, 2001 .

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.

J. K. Wood, S. M. Walters, James K. Wood, 2000, Journal of medicinal chemistry.

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

S. Joshi, D. Coulter, J. Sharp, 2016, BMC Cancer.

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

R. Prankerd, S. Charman, W. Charman, 2009, Antimicrobial Agents and Chemotherapy.

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

R. Prankerd, S. Charman, W. Charman, 2008, Antimicrobial Agents and Chemotherapy.

Running Title : Heme alkylation by trioxolane antimalarials 4 5

R. Prankerd, S. Charman, W. Charman, 2008 .

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Ted M. Lakowski, Donald W. Miller, T. Lakowski, 2018, Pharmaceutics.

Physicochemical Characterization of Creatine N-Methylguanidinium Salts

Donald W. Miller, N. Miller, B. Gufford, 2010, Journal of dietary supplements.

Polyfluorinated Bis-styrylbenzene β-Amyloid Plaque Binding Ligands

Shannon M Walsh, T. Kiyota, T. Ikezu, 2007 .

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

J. Karle, J. Chollet, S. Charman, 2007, Bioorganic & medicinal chemistry letters.

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

C. Siethoff, S. Charman, S. Duparc, 2012, British journal of clinical pharmacology.

Immunization to nicotine with a peptide-based vaccine composed of a conformationally biased agonist of C5a as a molecular adjuvant.

R. Bevins, G. Thiele, Srinivas Cheruku, 2003, International immunopharmacology.

Oxidants, Oxidant Drugs, and Malaria

J. Eaton, J. Vennerstrom, 1988 .

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

David M. Shackleford, J. Chollet, S. Charman, 2017, Journal of medicinal chemistry.

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.

J. Chollet, Yuxiang Dong, J. Vennerstrom, 2010, Bioorganic & medicinal chemistry letters.

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

J. K. Wood, J. Chollet, S. Charman, 2009, Bioorganic & medicinal chemistry letters.

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

J. Keiser, R. Guy, Jaeki Min, 2014, The American journal of tropical medicine and hygiene.

pH-Dependent Stability of Creatine Ethyl Ester: Relevance to Oral Absorption

Donald W. Miller, N. Miller, B. Gufford, 2013, Journal of dietary supplements.

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

G. Ruthel, P. Wipf, R. Gussio, 2010 .

Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity

P. Davis, Xiaofang Wang, J. Vennerstrom, 2015, Antimicrobial Agents and Chemotherapy.

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.

J. Chollet, S. Charman, D. Creek, 2007, Journal of medicinal chemistry.

Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice.

J. Keiser, J. Vennerstrom, M. Vargas, 2010, The Journal of antimicrobial chemotherapy.

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

J. K. Wood, James K. Wood, Yuxiang Dong, 2005, The Journal of organic chemistry.

Synthetic peroxides as antimalarials

Yuxiang Dong, J. Vennerstrom, Yuanqing Tang, 2004, Medicinal research reviews.

Peroxidic antimalarials

Yuxiang Dong, J. Vennerstrom, 2001 .

8-Aminoquinolines Active against Blood Stage Plasmodium falciparum In Vitro Inhibit Hematin Polymerization

L. Gerena, W. Milhous, Robert E. Miller, 1999, Antimicrobial Agents and Chemotherapy.

The activity of dispiro peroxides against Fasciola hepatica.

J. Keiser, Qingjie Zhao, Yuxiang Dong, 2011, Bioorganic & medicinal chemistry letters.

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

R. Prankerd, S. Charman, W. Charman, 2007, Journal of pharmaceutical sciences.

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions.

J. Karle, Yuxiang Dong, J. Vennerstrom, 2004, The Journal of organic chemistry.

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.

J. Keiser, D. Siegel, C. Caffrey, 2020, The Journal of antimicrobial chemotherapy.

Progress in antischistosomal N,N'-diaryl urea SAR.

David M. Shackleford, J. Keiser, S. Charman, 2017, Bioorganic & medicinal chemistry letters.

Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine.

J. Vennerstrom, A. Dorn, S. Vippagunta, 1999, Biochemical pharmacology.

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

J. Karle, J. Chollet, S. Charman, 2005, Journal of medicinal chemistry.

Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii

X. Wang, S. Charman, T. T. Schulze, 2018, International journal for parasitology. Drugs and drug resistance.

In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum.

W. Milhous, J. Le bras, J. Vennerstrom, 1994, The American journal of tropical medicine and hygiene.

Synthesis of 2-Azaadamantan-6-one: A Missing Isomer

Yuxiang Dong, Xiaofang Wang, J. Vennerstrom, 2018, ACS omega.

Short report: floxacrine analog WR 243251 inhibits hematin polymerization.

H. Matile, J. Vennerstrom, A. Dorn, 2001, The American journal of tropical medicine and hygiene.

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth.

S. Maiti, Srinivas Cheruku, A. Bhattacharjee, 2003, Journal of medicinal chemistry.

Differentiation between 1,2,4,5-tetraoxanes and 1,2,4,5,7,8-hexaoxonanes using 1H and 13C NMR analyses

Yuxiang Dong, J. Vennerstrom, 2001 .

Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.

J. K. Wood, James K. Wood, L. Gerena, 1992, Journal of medicinal chemistry.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

J. Chollet, S. Charman, W. Charman, 2010, Journal of medicinal chemistry.

Synthesis and antimalarial activity of amide and ester conjugates of siderophores and ozonides

M. Ferdig, Marvin J. Miller, L. Checkley, 2022, BioMetals.

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides.

Yuxiang Dong, J. Vennerstrom, D. Stack, 2017, Organic letters.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

J. Chollet, S. Charman, E. Ryan, 2013, Journal of medicinal chemistry.

Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines.

J. Garrison, Yuxiang Dong, Xiaofang Wang, 2020, The Journal of organic chemistry.

A one-pot synthesis of unsymmetrical bis-styrylbenzenes

Yuxiang Dong, J. Vennerstrom, D. P. Flaherty, 2009 .

Crystal structure of the potent bisquinoline antimalarial agent (±)-trans-N1,N2-bis(7-chloroquinolin-4-yl) cyclohexane-1,2-diamine dimethanesulfonate salt hydrate in relation to its biological properties

J. Karle, A. Bhattacharjee, J. Vennerstrom, 2002 .

Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines

M. Makler, J. Vennerstrom, C. Angerhofer, 1995, Antimicrobial agents and chemotherapy.

Synthesis of 2H-pyrroles by treatment of pyrrolidines with DDQ

Srinivas Cheruku, J. Vennerstrom, M. Padmanilayam, 2003 .

A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro.

H. Matile, J. Vennerstrom, A. Dorn, 1998, Biochemical pharmacology.

Antischistosomal Tetrahydro-γ-carboline Sulfonamides.

J. Keiser, M. Kaiser, Yuxiang Dong, 2022, Bioorganic & medicinal chemistry letters.

Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity

P. Davis, Xiaofang Wang, J. Vennerstrom, 2016, Antimicrobial Agents and Chemotherapy.

Novel Toxoplasma gondii inhibitor chemotypes.

X. Wang, S. Charman, T. T. Schulze, 2018, Parasitology international.

An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials.

H. Matile, J. Vennerstrom, A. Dorn, 1998, Biochemical pharmacology.

Differentiation Between 1,2,4,5-Tetraoxanes and 1,2,4,5,7,8-Hexaoxonanes Using 1H and 13C NMR Analyses.

Yuxiang Dong, J. Vennerstrom, 2001 .

Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica.

J. Keiser, Qingjie Zhao, Yuxiang Dong, 2010, Journal of medicinal chemistry.

Oxidants, oxidant drugs, and malaria.

J. Eaton, J. Vennerstrom, 1988, Journal of medicinal chemistry.

Protoberberine alkaloids as antimalarials.

D. L. Klayman, J. Vennerstrom, D. Klayman, 1988, Journal of medicinal chemistry.

Berberine derivatives as antileishmanial drugs

J. Lovelace, W. Hanson, V. B. Waits, 1990, Antimicrobial Agents and Chemotherapy.

Anticancer Properties of Distinct Antimalarial Drug Classes

K. Chibale, M. Phillips, R. Guy, 2013, PloS one.

Identification of an antimalarial synthetic trioxolane drug development candidate

Christian Scheurer, Jonathan L. Vennerstrom, Susan A. Charman, 2004, Nature.

Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications

R. Hallett, T. Wellems, J. Breman, 2012, The American journal of tropical medicine and hygiene.

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions.

K. Becker, H. Ginsburg, L. Tilley, 2004, International journal for parasitology.

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni.

J. Keiser, O. Braissant, Xiaofang Wang, 2011, Acta tropica.

Electrolysis-mediated irreversible inactivation of lipoxygenase directed toward electroaffinity labelling.

J. Vennerstrom, T. J. Holmes, V. John, 1984, Biochemical and biophysical research communications.

Drug Discovery and Development for Schistosomiasis

K. Becker, M. Schlitzer, D. Drewry, 2019, Neglected Tropical Diseases.

Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry.

J. Vennerstrom, A. Dorn, S. Vippagunta, 2000, Biochimica et biophysica acta.

Solution equilibria of deferoxamine amides.

P. M. Ihnat, J. Vennerstrom, D. Robinson, 2002, Journal of pharmaceutical sciences.

Synthesis and solution properties of deferoxamine amides.

D. Robinson, P. M. Ihnat, J. Vennerstrom, 2000, Journal of Pharmacy and Science.

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

S. Charman, Xiaofang Wang, J. Vennerstrom, 2018, Antimicrobial Agents and Chemotherapy.

Docking Studies on Isoform-Specific Inhibition of Phosphoinositide-3-Kinases

Dima A. Sabbah, Jonathan L. Vennerstrom, Haizhen Zhong, 2010, J. Chem. Inf. Model..

Binding Selectivity Studies of Phosphoinositide 3-Kinases Using Free Energy Calculations

Dima A. Sabbah, Jonathan L. Vennerstrom, Haizhen Zhong, 2012, J. Chem. Inf. Model..

Semipinacol and protoadamantane-adamantane rearrangements of 5,6-dibromoadamantan-2-one and -2-ol

J. K. Wood, James K. Wood, J. Garrison, 2017 .

Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl.

S. Bavari, G. Casale, J. Vennerstrom, 1993, Immunopharmacology and immunotoxicology.

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

R. Brun, H. Matile, M. Kaiser, 2007, Antimicrobial Agents and Chemotherapy.

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

S. Xiao, J. Xue, Yuxiang Dong, 2014, Parasitology Research.

Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes.

J. Keiser, A. Hemphill, Yuxiang Dong, 2014, International journal of antimicrobial agents.

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica.

M. Tanner, J. Utzinger, J. Keiser, 2006, The Journal of antimicrobial chemotherapy.

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica.

J. Utzinger, J. Keiser, I. Fairweather, 2007, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC).

P. Colombo, M. Longo, J. Craft, 2010, Reproductive toxicology.

CLONORCHICIDAL PROPERTIES OF THE SYNTHETIC TRIOXOLANE OZ78

J. Utzinger, J. Keiser, S. Xiao, 2007, The Journal of parasitology.

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.

J. Keiser, R. Kaminsky, J. Huwyler, 2010, Veterinary parasitology.

In Vitro and In Vivo Antischistosomal Activity Profiling and Pharmacokinetics of Ozonide Carboxylic Acids.

J. Keiser, S. Charman, Xiaofang Wang, 2023, ACS infectious diseases.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Christian Scheurer, Lukas Stingelin, David M. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.

R. Prankerd, S. Charman, W. Charman, 2006, Journal of pharmaceutical sciences.

Inhibition of cyclooxygenase mediated by electrochemical oxidation of gentisic acid.

J. Vennerstrom, T. J. Holmes, V. John, 1985, The Journal of biological chemistry.

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Rick Gussio, Sina Bavari, G. Ruthel, 2007, Journal of medicinal chemistry.

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

David M. Shackleford, J. Keiser, Jeremy O. Jones, 2016, Journal of medicinal chemistry.

Depentylation of [3H-pentyl]methyl-n-amylnitrosamine by rat esophageal and liver microsomes and by rat and human cytochrome P450 isoforms.

H. Gelboin, J. Vennerstrom, G. Xu, 1999, Cancer research.

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells

D. Creek, Dovile Anderson, G. Siddiqui, 2021, bioRxiv.

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα).

M. Brattain, Yuxiang Dong, J. Vennerstrom, 2012, Bioorganic & medicinal chemistry.

Oral Bioavailability of Creatine Supplements

Donald W. Miller, J. Vennerstrom, D. Robinson, 2019, Nutrition and Enhanced Sports Performance.

Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

J. K. Wood, James K. Wood, R. Kaminsky, 1999, Journal of medicinal chemistry.

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

J. K. Wood, James K. Wood, J. Chollet, 2007, Antimicrobial Agents and Chemotherapy.

Assessment of the antimalarial potential of tetraoxane WR 148999.

J. K. Hu, D. Wesche, J. Vennerstrom, 2000, The American journal of tropical medicine and hygiene.

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.

J. K. Wood, James K. Wood, D. Kyle, 2000, Journal of medicinal chemistry.

Dispiro‐1,2,4,5‐tetraoxanes via Ozonolysis of Cycloalkanone O‐Methyl Oximes: A Comparison with the Peroxidation of Cycloalkanones in Acetonitrile—Sulfuric Acid Media.

Yuxiang Dong, J. Vennerstrom, 1999 .

Dispiro-1,2,4,5-tetraoxanes via Ozonolysis of Cycloalkanone O-Methyl Oximes: A Comparison with the Peroxidation of Cycloalkanones in Acetonitrile−Sulfuric Acid Media

Yuxiang Dong, J. Vennerstrom, 1998 .

Dispiro‐1,2,4,5‐tetraoxanes: A New Class of Antimalarial Peroxides.

J. K. Wood, L. Gerena, W. Milhous, 1992 .

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.

M. Brattain, J. Vennerstrom, Haizhen A. Zhong, 2012, Bioorganic & medicinal chemistry letters.

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry letters.

Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

J. Keiser, B. Ernst, J. Vennerstrom, 2015, Antimicrobial Agents and Chemotherapy.

Inhibition of platelet aggregation by novel triphenylethylene analogs.

J. White, J. Vennerstrom, G. Rao, 1986, Thrombosis research.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

O. Biehlmaier, P. Mäser, H. Matile, 2015, ACS infectious diseases.

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

Yuxiang Dong, J. Vennerstrom, S. Wittlin, 2009, Antimicrobial Agents and Chemotherapy.

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

K. Malcolm, J. Nick, M. Zimmerman, 2022, Science Translational Medicine.

Peroxides as oxidant antimalarials.

N. Acton, D. L. Klayman, J. Vennerstrom, 1989, Drug design and delivery.

Ozonide antimalarials alkylate heme in the malaria parasite Plasmodium falciparum.

S. Charman, D. Creek, Dovile Anderson, 2019, ACS infectious diseases.

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

David M. Shackleford, J. Keiser, S. Charman, 2020, Journal of medicinal chemistry.

Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal.

J. Keiser, G. Panic, N. Gautam, 2015, The Journal of antimicrobial chemotherapy.

In Vitro Selection Implicates ROP1 as a Resistance Gene for an Experimental Therapeutic Benzoquinone Acyl Hydrazone in Toxoplasma gondii

Thomas T. Schulze, Harim I. Won, T. T. Schulze, 2020, Antimicrobial Agents and Chemotherapy.

A new chemotype with promise against Trypanosoma cruzi.

F. Buckner, P. Davis, G. Lepesheva, 2019, Bioorganic & medicinal chemistry letters.

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

David M. Shackleford, S. Charman, Qingjie Zhao, 2021, ACS infectious diseases.

Stochastic protein alkylation by antimalarial peroxides.

Remo S. Schmidt, P. Mäser, H. Matile, 2019, ACS infectious diseases.

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

A. Ruf, S. Charman, W. Charman, 2008, Bioorganic & medicinal chemistry letters.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

J. Chollet, S. Charman, W. Charman, 2010, Bioorganic & medicinal chemistry letters.

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry.

Diaryl Ureas as an Antiprotozoal Chemotype.

P. Davis, M. Kaiser, J. Vennerstrom, 2021, ACS infectious diseases.

Chapter 2:Semisynthetic Artemisinin and Synthetic Peroxide Antimalarials

L. Tilley, S. Charman, J. Vennerstrom, 2011 .

Amine peroxides as potential antimalarials.

J. Vennerstrom, 1989, Journal of medicinal chemistry.

Haematin (haem) polymerization and its inhibition by quinoline antimalarials.

J. Vennerstrom, A. Dorn, S. Vippagunta, 1997, Annals of tropical medicine and parasitology.

Mechanisms of in situ activation for peroxidic antimalarials

Yuxiang Dong, J. Vennerstrom, 2003, Redox report : communications in free radical research.

Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands.

Shannon M Walsh, T. Kiyota, T. Ikezu, 2007, Journal of medicinal chemistry.

Ligand-based design of GLUT inhibitors as potential antitumor agents.

S. Almahmoud, Xiaofang Wang, J. Vennerstrom, 2020, Bioorganic & medicinal chemistry.

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.

T. Kiyota, T. Ikezu, Yuxiang Dong, 2010, Journal of medicinal chemistry.

Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide.

Qingjie Zhao, Yuxiang Dong, J. Vennerstrom, 2014, Tetrahedron letters.

SAR of a new antischistosomal urea carboxylic acid.

David M. Shackleford, J. Keiser, S. Charman, 2018, Bioorganic & medicinal chemistry letters.

Docking Studies on Isoform-Specific Inhibition of Phosphoinositide-3-Kinases

J. Vennerstrom, Haizhen A. Zhong, D. Sabbah, 2010, J. Chem. Inf. Model..

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

J. Keiser, J. Chollet, Y. Alnouti, 2010, Bioorganic & medicinal chemistry letters.

Virtual screening and biological evaluation of PPARγ antagonists as potential anti-prostate cancer agents.

C. Hopkins, Jeremy O. Jones, S. Almahmoud, 2021, Bioorganic & medicinal chemistry.

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

J. Keiser, Jaeki Min, Qingjie Zhao, 2014, The American journal of tropical medicine and hygiene.

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

Yuxiang Dong, J. Vennerstrom, S. Wittlin, 2009, Antimicrobial Agents and Chemotherapy.

A 3D QSAR Pharmacophore Model and Quantum Chemical Structure-Activity Analysis of Chloroquine(CQ)-Resistance Reversal

Jonathan L. Vennerstrom, Dennis E. Kyle, Apurba K. Bhattacharjee, 2002, J. Chem. Inf. Comput. Sci..